CMR1_CANAL
ID CMR1_CANAL Reviewed; 602 AA.
AC Q59S45; A0A1D8PQT0; Q3MPL3;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN OrderedLocusNames=CAALFM_C701270CA; ORFNames=CaJ7.0141, CaO19.6907;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15937140; DOI=10.1534/genetics.104.034652;
RA Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T.,
RA Mikami Y.;
RT "Sequence finishing and gene mapping for Candida albicans chromosome 7 and
RT syntenic analysis against the Saccharomyces cerevisiae genome.";
RL Genetics 170:1525-1537(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR EMBL; AP006852; BAE44647.1; -; Genomic_DNA.
DR EMBL; CP017629; AOW30495.1; -; Genomic_DNA.
DR RefSeq; XP_712479.1; XM_707386.1.
DR AlphaFoldDB; Q59S45; -.
DR STRING; 237561.Q59S45; -.
DR PRIDE; Q59S45; -.
DR GeneID; 3645908; -.
DR KEGG; cal:CAALFM_C701270CA; -.
DR CGD; CAL0000176214; orf19.6907.
DR VEuPathDB; FungiDB:C7_01270C_A; -.
DR eggNOG; KOG4328; Eukaryota.
DR HOGENOM; CLU_017019_1_1_1; -.
DR InParanoid; Q59S45; -.
DR OMA; TVVRHNC; -.
DR OrthoDB; 753973at2759; -.
DR Proteomes; UP000000559; Chromosome 7.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR GO; GO:2000001; P:regulation of DNA damage checkpoint; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR033052; Cmr1/WDR76.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..602
FT /note="DNA damage-binding protein CMR1"
FT /id="PRO_0000351102"
FT REPEAT 229..270
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 291..328
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 390..430
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 446..484
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 526..569
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 571..602
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REGION 35..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 69057 MW; F20544265A389053 CRC64;
MALSELEKKR QENIRRNQEL LKKLDLDSIS DSIKKEVDNK SFSSPSSQKR RKTTKKPVIK
KEISEPSRRS RRIAGIKSEL EDPKQAARIR EEEELKQHRK QELERLKRTR LFGDFKLIDL
ITNKKGDMIF EKNVMDRKLS HIGLDSKVEE KKNEEDKEDE EEAINIDENN RVLQLVQSLG
DKFSAGDFYE EIRNSQTNGN SKDKSLDAKR KEFDNLNIYP RFDPLDIKIC HNRITSMFFH
PSTTNRIVVG GDTTGNVGIW LVDEQNNDTK EEEEDDDDDE PSISILQLHG RNVSKIMTPT
FSPEKIYTSS YDGSIRVLDL NKLTSTELLY LNEPGAREDI ALGVSDINQC QDSSVIFMTT
LDGEFYQHDT RTPFNTRQRH HLATKDLLRL HDKKIGGFAV NPNTNYQIAT ASLDRTLRIW
DLRNVNKSVY SEFENQKSPH MYGNYNSRLS VSCVDWNQEN RLVCNGYDDN ICLFDYSGGS
KLDNELPVIT EWKSDFVPST KSSEESELLP NNLTPFTKIK HNCQTGRWVS ILKSHWQTNP
ADGVQKFIIA NMNRGLDIYN QDGQILAHLN EQVGAVPAVC TLHPSQNWAV GGSASGKVYL
FE
