CMR1_CHAGB
ID CMR1_CHAGB Reviewed; 524 AA.
AC Q2HHH2;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN ORFNames=CHGG_00332;
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR EMBL; CH408029; EAQ92097.1; -; Genomic_DNA.
DR RefSeq; XP_001219553.1; XM_001219552.1.
DR AlphaFoldDB; Q2HHH2; -.
DR SMR; Q2HHH2; -.
DR STRING; 38033.XP_001219553.1; -.
DR EnsemblFungi; EAQ92097; EAQ92097; CHGG_00332.
DR GeneID; 4388252; -.
DR eggNOG; KOG4328; Eukaryota.
DR HOGENOM; CLU_017019_1_1_1; -.
DR InParanoid; Q2HHH2; -.
DR OMA; TVVRHNC; -.
DR OrthoDB; 753973at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR033052; Cmr1/WDR76.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..524
FT /note="DNA damage-binding protein CMR1"
FT /id="PRO_0000351104"
FT REPEAT 184..225
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 245..285
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 295..332
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 336..376
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 385..425
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 447..490
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 493..524
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REGION 35..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 57094 MW; D06D70124E1697DC CRC64;
MPPKKEPVIS AFERKRLENI ANNNAILSGI STTAEKIIPK PAPPKPKRAS APRAKREPVK
RETARPTRQS SRLAGLDADA DTLKRKAEVE AEVEAEKAKA KKMRVSGDLS LGDIQVEGRK
WENGLDGLAG LKGLSARGAQ PGIRTFTDED VKGTTDKGLK DLRLRMSGLK LYEKWPVQGA
YPKLVPQRVY SLGFHPTESK PIIFAGDKEG AMGVFDASQE PVKAEDDDDD EEAEIPDPII
SAFKTHSRTI TSFHFSPVDA NAVYSASYDS SIRKLDLDKG VSTEAFAPAD ADEDLPISAI
DMPTSDPNMI IFSTLQGTLG RHDLRTKSST AEIWGLTDQK IGGFSLHPAQ PHLVATASLD
RTLKIWDLRK IQGKGDARAP ALLGTHDSRL SVSHASWSSA GHVATSSYDD RIKIYNFPDA
DKWTAGAALT EAQMEPARQI PHNNQTGRWV TILKPQWQRS PRDGLQKFVI GNMNRFVDVF
AADGEQLAQL GGDGITAVPA VAHFHPTMDW VAGGNGSGKL CLWM
