ID   CMR1_COCIM              Reviewed;         525 AA.
AC   Q1E6Q0; J3KK89;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN   ORFNames=CIMG_01763;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; GG704911; EAS36409.3; -; Genomic_DNA.
DR   RefSeq; XP_001247992.1; XM_001247991.2.
DR   AlphaFoldDB; Q1E6Q0; -.
DR   SMR; Q1E6Q0; -.
DR   STRING; 246410.Q1E6Q0; -.
DR   EnsemblFungi; EAS36409; EAS36409; CIMG_01763.
DR   GeneID; 4566785; -.
DR   KEGG; cim:CIMG_01763; -.
DR   VEuPathDB; FungiDB:CIMG_01763; -.
DR   InParanoid; Q1E6Q0; -.
DR   OMA; TVVRHNC; -.
DR   OrthoDB; 753973at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..525
FT                   /note="DNA damage-binding protein CMR1"
FT                   /id="PRO_0000351105"
FT   REPEAT          183..224
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          241..281
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          288..328
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          339..379
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          384..425
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          448..491
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          494..525
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REGION          38..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   525 AA;  58455 MW;  1B490248DB8C8758 CRC64;
     MPRTKEEPEL SEFEKQRAAN IAERDALLKK LTLEAQSAGI FSKPPASKSS SQTKKKPAPK
     RVKKEDEPPV PRRMSSRLRG LAAESEIAKR KAEDEYQAMK AAAQAKRMRI SGDLNVGDIV
     VGENKWNETG LQGLGIVNSA QRYQRTFGEE DIKKTTNKEL KELREKMSGL QLWEPWEPNR
     IKITRERIYS MLFHPTESKP LIFAGDKTGH LGILDASQQP DQNESDEEDE YPDPTITTIK
     PHTNTISAMH IHPSDPSKLY SGSYDSSIRA LDLEKSVATE AYAPASSSDD EPLSGIDMAP
     TDPHVLYFTT LDGFFGRHDM RVSSKANPGD GSAVTFYQLS EKKIGGFSLC PTQPHYMATA
     SLDRTMKVWD LRHLSTKHPK PVGEHESSLS VSHAAFNQKG QIATTSYDNS IKIYDLASKG
     LKDWKPNHTL SEDEMAPDAV IRHNCQTGKW VTILRPQWQA CPDSPVERFC IGNMNRFVDI
     YTSTGEQLAQ LGADVITAVP AVAVFHRTQN WVVGGTGSAK VCLWM