ID   CMR1_CRYNJ              Reviewed;         595 AA.
AC   P0CS56; Q55MZ1; Q5KBC0;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN   OrderedLocusNames=CNI03070;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017349; AAW45607.1; -; Genomic_DNA.
DR   RefSeq; XP_572914.1; XM_572914.1.
DR   AlphaFoldDB; P0CS56; -.
DR   STRING; 5207.AAW45607; -.
DR   PaxDb; P0CS56; -.
DR   PRIDE; P0CS56; -.
DR   EnsemblFungi; AAW45607; AAW45607; CNI03070.
DR   GeneID; 3259611; -.
DR   KEGG; cne:CNI03070; -.
DR   VEuPathDB; FungiDB:CNI03070; -.
DR   eggNOG; KOG4328; Eukaryota.
DR   HOGENOM; CLU_017019_1_0_1; -.
DR   InParanoid; P0CS56; -.
DR   OMA; TVVRHNC; -.
DR   OrthoDB; 753973at2759; -.
DR   Proteomes; UP000002149; Chromosome 9.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   GO; GO:2000001; P:regulation of DNA damage checkpoint; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..595
FT                   /note="DNA damage-binding protein CMR1"
FT                   /id="PRO_0000351106"
FT   REPEAT          185..226
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          255..297
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          300..339
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          349..389
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          448..487
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          519..556
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          558..595
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REGION          20..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          397..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..418
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   595 AA;  66035 MW;  60D84ECE00063A36 CRC64;
     MDEETAYELE RQKTIAENRA LLDSLGLDPA GASSPFGSSP APTSNKTKPK PKPAPKKRKA
     AAVIAVDEGP RRRSGRIAGL EADGDAFKAK VEEEEKEREI LRVVSRKERE KVMDVGKMVE
     DTPEDEIKDM EKYLQSIAEL SNPRTYPAGT VSAREAYADS DTVPSEVQRL KDAFKDMSLK
     GNTKVTNERV FSMCVHPEKT KTLVLVGDKY GQLGIWDALG PPMEKPENED DTSGLLRAEG
     EDEYQEGRVW RVQAHAKNSI SCMKVDPVNG SGLFSTAYDC SLRHLSFSTL QSTELFSFQD
     EDLLINHFDL LPSAQEAWMV DKNGGISHWD TRESKRESGR RRWVVQEEGR GAKLGGVSVN
     PLMPHLICTA GNDQHVRIWD TRHLFSISSN LVPSAAAIEE EEEGTSTLSG QSSSLPHDTH
     PTRESDYSTV TSYLASPRGK GLMRAKWQHG KSCSSAYWDP WGRRILTTSY DDHLRVFNID
     PGSSLVDDRA VGSLLQPNGF KPTKVVRHNC QTGRWLTILR AQWSLNMEYM PHFTVGNMKR
     TLDVVSATGE KIVGLWTDDV TAVPTVTASH PNIVDRVVGG NTSGRIQLWS SGDHI