ID   CMR1_DEBHA              Reviewed;         584 AA.
AC   Q6BKH9;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN   OrderedLocusNames=DEHA2F21868g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; CR382138; CAG89693.2; -; Genomic_DNA.
DR   RefSeq; XP_461292.2; XM_461292.1.
DR   AlphaFoldDB; Q6BKH9; -.
DR   STRING; 4959.XP_461292.2; -.
DR   EnsemblFungi; CAG89693; CAG89693; DEHA2F21868g.
DR   GeneID; 2903365; -.
DR   KEGG; dha:DEHA2F21868g; -.
DR   VEuPathDB; FungiDB:DEHA2F21868g; -.
DR   eggNOG; KOG4328; Eukaryota.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   InParanoid; Q6BKH9; -.
DR   OMA; TVVRHNC; -.
DR   OrthoDB; 753973at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; DNA damage; DNA-binding; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..584
FT                   /note="DNA damage-binding protein CMR1"
FT                   /id="PRO_0000351107"
FT   REPEAT          226..267
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          274..314
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          373..413
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          431..469
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          506..549
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          553..584
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REGION          29..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          76..110
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        29..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   584 AA;  66764 MW;  E1C03367CA546822 CRC64;
     MAPLSDFEKQ RQENIQRNKD LLRKLNLDSA TDSISREIPN QRQANGAKKR KTNNAAKPIK
     KEPQEPSRRS RRLAGVTMEN TEEYQKVKEE MEEAERKKKE LEKLKSTRLF GNFHLIDLVT
     DKRSGDMKFE KKVLKLPNEI KKEENNTKEI KEEEDDHLQD DDINIESDNK VLEILKDLGD
     KFSAGDFYDL IRNSSSDYDD KGLESKRNEF DNLKLFERFD PLDIKITHQR ITAINFHPSK
     TDRVITAGDK VGNLGIWAVD STEDEDPAIT ILKPHGRSIA KILTPHSNPS KIYSCAYDGS
     VRELDLNKLE SSEVIYLKDP YESQDYPLAV SDINLCQEGN PNVLYLTTLG GHFYQHDLRT
     PFKSIKPNSL LRLHDKKIGS FCINPNLSHQ IATASLDRTF RIWDLRNISK SNSSWSEYED
     QISPHVYGSY SSRLSVSSVD WNYENRLVCN GYDDTINIFD LSSESSELPP VTEWSKTYQT
     GTKNKDEQIP TNIKPFTRIK HNCQTGRWVS ILKSRWQASP GDGIQKFVIA NMNRGLDIYD
     QKGQILAHLT DSEKVGAVPA VAAMHPIENW CVGGSASGKL YLFE