CMR1_EMENI
ID CMR1_EMENI Reviewed; 525 AA.
AC Q5B6U3; C8V7B2;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=DNA damage-binding protein cmr1 {ECO:0000250|UniProtKB:Q12510};
GN ORFNames=AN3737;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR EMBL; AACD01000061; EAA59945.1; -; Genomic_DNA.
DR EMBL; BN001302; CBF75499.1; -; Genomic_DNA.
DR RefSeq; XP_661341.1; XM_656249.1.
DR AlphaFoldDB; Q5B6U3; -.
DR SMR; Q5B6U3; -.
DR STRING; 162425.CADANIAP00004986; -.
DR EnsemblFungi; CBF75499; CBF75499; ANIA_03737.
DR EnsemblFungi; EAA59945; EAA59945; AN3737.2.
DR GeneID; 2873159; -.
DR KEGG; ani:AN3737.2; -.
DR VEuPathDB; FungiDB:AN3737; -.
DR eggNOG; KOG4328; Eukaryota.
DR HOGENOM; CLU_017019_1_1_1; -.
DR InParanoid; Q5B6U3; -.
DR OMA; TVVRHNC; -.
DR OrthoDB; 753973at2759; -.
DR Proteomes; UP000000560; Chromosome II.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR GO; GO:2000001; P:regulation of DNA damage checkpoint; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..525
FT /note="DNA damage-binding protein cmr1"
FT /id="PRO_0000351108"
FT REPEAT 182..223
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 247..287
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 339..379
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 384..425
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 448..491
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 494..525
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REGION 34..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 58696 MW; D3F4C1902B1E5829 CRC64;
MVKEELSEFE KQRLANIAER DALLKKLSLD AQSTGVFTSN MPRGTSANQS KPKKKPAPKV
KKEESLLPRR TSSRLRGIAA DSEIAKRKAD EEYDRRQEEE RAKRVRKSDS FSFNDIFVSG
QKLSGDALIG VDVVTKGVAV PYQRTFGEED IKSTDDKDLK ALRKEMNSLS LWEAWEPNRI
KITPERIYSM TFHPSEAKPV IFAGDKMGHL GILDASQEKP TSAVKNEDDE DDEDDDDPDP
VLVTLKPHTR TISSMTVHPS KPTHLYTASY DSSIRELDLE KTSSVEKYAP ESTSDDVPIS
GLDMAAGDPN TIYWTTLDGA FGRYDMRTKR QSSATTWQLS EKKIGGFSLY QTHPHYVATA
SLDRTMRLWD IRNLSHTDPT PVGEHQSRLS VSHAAFNCVG QIATSSYDDT LKLYDFSSKG
ISSWKPGHIL DESEMKPDTI VRHNCQTGRW VTILRPQWQL NPQSAIQRFC IGNMNRFVDI
YSGSGDQLAQ LGGDGITAVP AVAVFHRSKN WVAGGTASGK ICLWM
