ID   CMR1_KLULA              Reviewed;         512 AA.
AC   Q6CT00;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN   OrderedLocusNames=KLLA0C16533g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01790.1; -; Genomic_DNA.
DR   RefSeq; XP_452939.1; XM_452939.1.
DR   AlphaFoldDB; Q6CT00; -.
DR   SMR; Q6CT00; -.
DR   STRING; 28985.XP_452939.1; -.
DR   EnsemblFungi; CAH01790; CAH01790; KLLA0_C16533g.
DR   GeneID; 2892075; -.
DR   KEGG; kla:KLLA0_C16533g; -.
DR   eggNOG; KOG4328; Eukaryota.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   InParanoid; Q6CT00; -.
DR   OMA; TVVRHNC; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   GO; GO:2000001; P:regulation of DNA damage checkpoint; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..512
FT                   /note="DNA damage-binding protein CMR1"
FT                   /id="PRO_0000351109"
FT   REPEAT          189..230
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          241..281
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          289..329
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          333..373
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          390..429
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          442..481
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          482..512
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REGION          32..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..80
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  58022 MW;  14A55614E3871785 CRC64;
     MGELTEFQKK RLENIKRNND LLKKLNLNNV SSQIKREAGV EDEHLDRKRK KKAGSAKKAV
     KKEPKPAAIP TRRSRRLRGE NVDGNGIPNV NDNQLLKMGQ SDSTPELEAI DELKNTALSG
     DVKLSDLIKS ENEEELLDKF KSFANKNFSS GDFFKELQQQ QVPTPEIKQL QEDFDLKLYD
     IFQPNEIKLT AERISATFFH PSVDKKLVIC GDTAGNVGLW NVRETQPEDE LEEPDITKVK
     LFTKNVGRID TYATDSSRLL AASYDGYLRS INLQDMNSEE ILVLKNEYDD PLGISDFQFN
     YNDPNVLFMT TLSGEFTTFD VRTKPTEINL KRLSDKKIGS FSINPKRPYE IATGSLDRTL
     KIWDTRKIVN KPEWSQYEDF ASHEIVATYD SRLSVSAVSY SPMDETLVCN GYDDTIRLFD
     VSGTLPEDLQ PKLTLKHNCQ TGRWTSILKA RFKLNMDVFA IANMKRAIDI YTSSGVQLAH
     LPTATVPAVI SWHPTQNWVV GGNSSGKAFL FT