ID   CMR1_NEOFI              Reviewed;         527 AA.
AC   A1DNV8;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA damage-binding protein cmr1 {ECO:0000250|UniProtKB:Q12510};
GN   ORFNames=NFIA_058290;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; DS027698; EAW16479.1; -; Genomic_DNA.
DR   RefSeq; XP_001258376.1; XM_001258375.1.
DR   AlphaFoldDB; A1DNV8; -.
DR   SMR; A1DNV8; -.
DR   STRING; 36630.CADNFIAP00005178; -.
DR   EnsemblFungi; EAW16479; EAW16479; NFIA_058290.
DR   GeneID; 4584892; -.
DR   KEGG; nfi:NFIA_058290; -.
DR   VEuPathDB; FungiDB:NFIA_058290; -.
DR   eggNOG; KOG4328; Eukaryota.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   OMA; TVVRHNC; -.
DR   OrthoDB; 753973at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   GO; GO:2000001; P:regulation of DNA damage checkpoint; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..527
FT                   /note="DNA damage-binding protein cmr1"
FT                   /id="PRO_0000351110"
FT   REPEAT          185..226
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          249..289
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          296..336
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          341..381
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          388..427
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          450..493
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          496..527
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REGION          35..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          284..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   527 AA;  58395 MW;  5D8B347CAB1E7013 CRC64;
     MGADNELSEF EKQRLANIAE RDALLKKLTL DAQSAGLFPP KSARSSPGGL TKPKKKPAPK
     KVKKEDEDLV PRRMSSRLRG LAADSEVAKR KADEQYEAAQ QAERAKRVRK SDAFSFSEML
     VSGQKLSGDS LIGVDVVTKG VAMPYQRTFG DDDIKKTTDK ELKALREEMS GLRLWEAWEP
     NRIKLTPERI YTMTFHPSEA KPLIFAGDKM GNLGVLDASQ EKPISAVKQE DDEDAEDDDP
     DPVLTTLKPH TRTISSMHVH PSKPTHLYSA SYDSSIRELD LEKTTSVEKY APESTSDDIP
     ISGIDMAPDD PNTLYWTTLD GAFGRYDTRA SRRSAVATWQ LSEKKIGGFS LFPTHPHFFA
     TASLDRTMRL WDIRKLSHDE PVPVGEHVSR LSVSHAAFNS AGQIATSSYD DTLKIYDFGS
     KGIAAWKPGH TLSDAEMKPD TIVRHNCQTG RWVTILRPQW QANPQSPIQR FCIGNMNRFV
     DVYSSSGDQL AQLGGDGITA VPAVAVFHRS TNWIAGGTAS GKICLWM