ID   CMR1_NEUCR              Reviewed;         521 AA.
AC   Q7S1H9;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=DNA damage-binding protein cmr1 {ECO:0000250|UniProtKB:Q12510};
GN   ORFNames=NCU09302, NCU11420;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; CM002242; EAA29212.1; -; Genomic_DNA.
DR   RefSeq; XP_958448.1; XM_953355.2.
DR   AlphaFoldDB; Q7S1H9; -.
DR   SMR; Q7S1H9; -.
DR   STRING; 5141.EFNCRP00000009833; -.
DR   EnsemblFungi; EAA29212; EAA29212; NCU09302.
DR   GeneID; 23568508; -.
DR   KEGG; ncr:NCU09302; -.
DR   VEuPathDB; FungiDB:NCU09302; -.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   InParanoid; Q7S1H9; -.
DR   OMA; TVVRHNC; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR   GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   GO; GO:2000001; P:regulation of DNA damage checkpoint; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..521
FT                   /note="DNA damage-binding protein cmr1"
FT                   /id="PRO_0000351111"
FT   REPEAT          183..224
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          242..282
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          333..373
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          382..422
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          490..521
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REGION          36..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..68
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  57655 MW;  4E45C2A0437C69E2 CRC64;
     MPPRKKETVM SEFERKRLEN IAYNNAILSG ISTTADKIIP KPAPPKPKRA STPRVKREPV
     KKEAARPTRQ SSRLAGLEAD SAVLKRKLDV EAEEEAAKAK AKRMRVSGDL NLGDITVEGR
     KWESSADGLA LLKGLGVRGA QPGVRTFTEK DVKHTKDKGL KDLRLRMSGL KLYEKWAVND
     IKIVPQRIYS MCFHPTEEKP IIFAGDKEGA MGVFDASQPT PKIEDDDEDA EYPDPIISAF
     KTHSRTISSF HFSPTDANAI YSASYDSSIR KLDLDKGIST EIFAPSSSSE DLPISAIDIP
     TTDPNMIIFS TLHGSLGRQD QRTKPSSAEI WGLTDHKIGG FSLHPRHPYL VATASLDRTL
     KIWDLRKITG KGDLRHPALL GEHESRLSVS HASWSSSGHI ATSSYDDRIK IYSFPSAGEW
     KAGHDIPAKE MQPTVEIPHN NQTGRWVTIL KPQWQRNPQD GWQKFAIGNM NRFVDVYAED
     GEQLAQLGGD GITAVPAVAH FHPTKDWVAG GTASGKLCLW M