ID   CMR1_PICGU              Reviewed;         573 AA.
AC   A5DAQ7;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN   ORFNames=PGUG_00362;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; CH408155; EDK36264.2; -; Genomic_DNA.
DR   RefSeq; XP_001486985.1; XM_001486935.1.
DR   AlphaFoldDB; A5DAQ7; -.
DR   STRING; 4929.XP_001486985.1; -.
DR   EnsemblFungi; EDK36264; EDK36264; PGUG_00362.
DR   GeneID; 5129228; -.
DR   KEGG; pgu:PGUG_00362; -.
DR   VEuPathDB; FungiDB:PGUG_00362; -.
DR   eggNOG; KOG4328; Eukaryota.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   InParanoid; A5DAQ7; -.
DR   OMA; TVVRHNC; -.
DR   OrthoDB; 753973at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil; DNA damage; DNA-binding; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..573
FT                   /note="DNA damage-binding protein CMR1"
FT                   /id="PRO_0000351113"
FT   REPEAT          218..259
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          268..308
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          319..357
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          361..401
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          418..456
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          495..538
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          542..573
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REGION          27..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          72..152
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        50..94
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   573 AA;  66386 MW;  8579A2614B90A623 CRC64;
     MTLSDFEKQR QENIQRNKEL LRQLELDSLN DSISREVPKP KPKAKRRKTE NARVKTEPIM
     PSRRSRRLAG STMEDSEEDK QMREEMEKAE ERKRELEKLK STRLFGDFKL IDLVVNKQGE
     FKNQDKILKA KEKDNEIKKE EKEEIKKEED STDSIDLSRD NEVLQKLQQL GDRFSAGDFY
     EMIKDTKSKY DDTVLQEKRE EFDRVKLYER FDPLDIKITQ QRITSIAFHP AKDDRVVVAG
     DTTGYVGIWA VDAKGDDETS PHITILKPHG KAVARILTPE QQPSSILTCS YDGSVRRLDL
     KRLESTEVAY LQDPYESSDY PLGVSDINVA DNNLLYMTTL SGNFYRYDMR SPFKQGELLR
     LHDKKIGSFS INPNAFHQIA TASLDRTMKL WDLRNISQKN SYWSEFDDKS PHLYCTYHSR
     LSVSCVDWNH DNHLVCNGYD DTVNVFDLSG SDKLPLVTEW SKDYETEKKK RTTIEDGVPE
     KLEALTRIKH NCQTGRWVSI LKSKWQLHPA DGLQKFVIAN MNRAFDIYDQ KGRILCHLTD
     PDRMTAVPAV SMLHPTENWC VGGSASGKVY LFE