ID   CMR1_PICST              Reviewed;         514 AA.
AC   A3LWH8;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN   Name=PRW1; ORFNames=PICST_83842;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; CP000499; ABN67280.2; -; Genomic_DNA.
DR   RefSeq; XP_001385309.2; XM_001385272.1.
DR   AlphaFoldDB; A3LWH8; -.
DR   SMR; A3LWH8; -.
DR   STRING; 4924.XP_001385309.2; -.
DR   PRIDE; A3LWH8; -.
DR   EnsemblFungi; ABN67280; ABN67280; PICST_83842.
DR   GeneID; 4839288; -.
DR   KEGG; pic:PICST_83842; -.
DR   eggNOG; KOG4328; Eukaryota.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   InParanoid; A3LWH8; -.
DR   OMA; TVVRHNC; -.
DR   OrthoDB; 753973at2759; -.
DR   Proteomes; UP000002258; Chromosome 5.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..514
FT                   /note="DNA damage-binding protein CMR1"
FT                   /id="PRO_0000351114"
FT   REPEAT          180..221
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          229..269
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          280..320
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          327..367
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          385..423
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          438..481
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          483..514
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REGION          26..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   514 AA;  58340 MW;  062BCF65C10B978C CRC64;
     MAKISEFERQ RQENIQRNKE LLKSLNLDSL SQSIKRELPR ASETKKRKTT PRTKAVKKED
     VEPSRRSRRI AGIKSELENP EEYNHKKSGS LKFEDKVIKS DSTEPEVKQE EKEELSEDIK
     NDNKVLHRLQ ALGDKFSAGD FFDIIQKNPI QYDDKVLQST RDEFDKLKIY EKHNPLDIKI
     SHTRITAINF HPSTTDRVVA AGDTNGNVGI WAVDSGEDDS EPTISILRPH GKAISRILTP
     VAEQNKLYSA SYDGSVRVLD LNKLASTEVV YLNDPYENDD YALGVSDINF CASDANLLYM
     TTLSGSFHKH DIRTPFKPLK SKDILRLHDK KIGSFSINPN NTYQIATASL DRTLRIWDLR
     NVSKANAEWS EFENQISPHL YGSFSSRLSV SCVDWNSENR LVCNGYDDYI NIFDLNEESL
     IPDNLKAFNK IKHNCQTGRW VSILKSKWQV APEDGVQKFV IANMNRALDI YDQKGQIIAH
     LTDSVGAVPA VCGFHPTKNW VVGGSASGKV YLFE