ID   CMR1_VANPO              Reviewed;         536 AA.
AC   A7TL17;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN   ORFNames=Kpol_530p43;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; DS480411; EDO17073.1; -; Genomic_DNA.
DR   RefSeq; XP_001644931.1; XM_001644881.1.
DR   AlphaFoldDB; A7TL17; -.
DR   SMR; A7TL17; -.
DR   STRING; 436907.A7TL17; -.
DR   EnsemblFungi; EDO17073; EDO17073; Kpol_530p43.
DR   GeneID; 5545265; -.
DR   KEGG; vpo:Kpol_530p43; -.
DR   eggNOG; KOG4328; Eukaryota.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   InParanoid; A7TL17; -.
DR   OMA; SISIAYF; -.
DR   OrthoDB; 753973at2759; -.
DR   PhylomeDB; A7TL17; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..536
FT                   /note="DNA damage-binding protein CMR1"
FT                   /id="PRO_0000351116"
FT   REPEAT          195..236
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          251..291
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          346..386
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          403..442
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          456..495
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          496..535
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REGION          36..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  60763 MW;  DBA2824F2B8A8B9B CRC64;
     MVELTEFQKR RQENIKRNND LLKKLHLGGA ASRIKREAGV DDTHRTVVKK KKSPSVSRGR
     SASPKVAPVA TRRSMRLRGE KVDNVGIPNV SDTQLMKMSL DGTSGSSVND KELVDEIKDT
     PVIGDVKLSD LIKDEKEENL IEKFKSFANK NFSSGDFFEE IRKRQMENKA PELQKLQDDF
     DLQLYDVFQP NEIKLVYERI TATYFHPSLD KKLIVAGDTS GNIGLWNVRD EPLSENGEDQ
     MVEPDITKVK FFTKNVGKID CFTSDTSKLL TASYDGSLRS IDLNSLQSND ILTLRNEYDD
     PLGISDFQFS YENPNVLLMT TLSGEFVNID LREKIGEQIS SNLRRLSDKK IGSFSINPNR
     PYEIATGSLD RTLKIWDIRK LVKKPEWSQY EDYDSCEIVS VYDSRLSVSA VSYSPTDNTL
     VCNGYDDTIR LFDVGSDNLP DDLQPKLTLK HNCQSGRWTS ILKARFKQDQ DVFAIANMKR
     AIDIYDSQGQ QLAHLPTATV PAVISWHPLR NWIAGGNSSG KIFLFTDETV KKEEEE