ID   CMR1_YARLI              Reviewed;         539 AA.
AC   Q6C0U2;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=DNA damage-binding protein CMR1 {ECO:0000250|UniProtKB:Q12510};
GN   OrderedLocusNames=YALI0F21747g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: DNA-binding protein that binds to both single- and double-
CC       stranded DNA. Binds preferentially to UV-damaged DNA. May be involved
CC       in DNA-metabolic processes. {ECO:0000250|UniProtKB:Q12510}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78531.1; -; Genomic_DNA.
DR   RefSeq; XP_505720.1; XM_505720.1.
DR   AlphaFoldDB; Q6C0U2; -.
DR   SMR; Q6C0U2; -.
DR   STRING; 4952.CAG78531; -.
DR   PRIDE; Q6C0U2; -.
DR   EnsemblFungi; CAG78531; CAG78531; YALI0_F21747g.
DR   GeneID; 2907839; -.
DR   KEGG; yli:YALI0F21747g; -.
DR   VEuPathDB; FungiDB:YALI0_F21747g; -.
DR   HOGENOM; CLU_017019_1_1_1; -.
DR   InParanoid; Q6C0U2; -.
DR   OMA; TVVRHNC; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   GO; GO:2000001; P:regulation of DNA damage checkpoint; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR033052; Cmr1/WDR76.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR14773:SF0; PTHR14773:SF0; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA-binding; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..539
FT                   /note="DNA damage-binding protein CMR1"
FT                   /id="PRO_0000351117"
FT   REPEAT          182..223
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          226..268
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          316..356
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          377..415
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          462..505
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          508..539
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REGION          22..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   539 AA;  59907 MW;  4F723B5C9A027BCE CRC64;
     MSELEQIRLA NIERNKALLA ALNLPTEAKK ESVDPEVAPK KSRKRNSARL ESPDDGSDDS
     APRTRRKSRR LQGLDPEANA LKQEDLGGSG ELKRLMQQLN GGVKKERLSG DLSLKEMLTK
     TGLDEKEWSA SLGQLFGDGS RVSQGDFFDE IVKKEEEDTK DIDIKQSRDN LSGLQLGKMS
     KVTKERIYIT AVHPGTDKRI VLAGDKIGVL GIWDVDSDNE PLQLQLHHAT IPALCFDQNS
     NDILYSASYD GSVRSLELKT GKSGDVLDLE AKKNASVGVS DVANPQPHLL YASTLCGHLI
     RKDLRTKSTE YETLILGEKK IGGFSVDPIN THLLATGSLD RSMRIWDLRA TETARTIPGG
     EVIDTQFQMP HLQAIYNSRL SVSSTDWNLA GQIVCNGYDD TINIFNQSDY FLDMLNDGNG
     TEPVKKTRRT RNSKLAEPEI SDQELPEIKK PSVRIKHNCQ TGRWVTILKA RWQQQPLDGV
     QKFAIANMNR YIDIYSGTGH QLAHLGDALM TAVPSALAFH PTQNWIAGGN SSGKMYWWE