CMR3_YEAST
ID CMR3_YEAST Reviewed; 317 AA.
AC Q12145; D6W424;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Zinc finger protein CRM3 {ECO:0000303|PubMed:21763361};
DE AltName: Full=Changed mutation rate protein 3 {ECO:0000303|PubMed:21763361};
GN Name=CMR3 {ECO:0000303|PubMed:21763361}; OrderedLocusNames=YPR013C;
GN ORFNames=LPZ12c;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP DOMAIN.
RX PubMed=9171100; DOI=10.1093/nar/25.12.2464;
RA Boehm S., Frishman D., Mewes H.-W.;
RT "Variations of the C2H2 zinc finger motif in the yeast genome and
RT classification of yeast zinc finger proteins.";
RL Nucleic Acids Res. 25:2464-2469(1997).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=18366603; DOI=10.1186/1471-2164-9-s1-s14;
RA Mao J., Habib T., Shenwu M., Kang B., Allen W., Robertson L., Yang J.Y.,
RA Deng Y.;
RT "Transcriptome profiling of Saccharomyces cerevisiae mutants lacking C2H2
RT zinc finger proteins.";
RL BMC Genomics 9:S14-S14(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
RN [6]
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=21763361; DOI=10.1016/j.jbiotec.2011.06.038;
RA Zhao X.Q., Bai F.W.;
RT "Zinc and yeast stress tolerance: micronutrient plays a big role.";
RL J. Biotechnol. 158:176-183(2012).
CC -!- FUNCTION: Probable transcription factor involved in the regulation of
CC the transcription of genes involved in cell rescue and defense, as well
CC as cell cycle and DNA processing. {ECO:0000269|PubMed:18366603,
CC ECO:0000305|PubMed:21763361}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:18366603}.
CC -!- DISRUPTION PHENOTYPE: Leads to altered expression of 79 genes,
CC including genes related to transcription, genes involving cell rescue
CC and defense, and genes involved in cell cycle and DNA processing.
CC {ECO:0000269|PubMed:18366603}.
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DR EMBL; U31900; AAA97591.1; -; Genomic_DNA.
DR EMBL; Z49919; CAA90157.1; -; Genomic_DNA.
DR EMBL; Z71255; CAA95009.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11440.1; -; Genomic_DNA.
DR PIR; S57546; S57546.
DR RefSeq; NP_015338.1; NM_001184110.1.
DR AlphaFoldDB; Q12145; -.
DR BioGRID; 36191; 113.
DR IntAct; Q12145; 1.
DR MINT; Q12145; -.
DR STRING; 4932.YPR013C; -.
DR iPTMnet; Q12145; -.
DR PaxDb; Q12145; -.
DR PRIDE; Q12145; -.
DR EnsemblFungi; YPR013C_mRNA; YPR013C; YPR013C.
DR GeneID; 856123; -.
DR KEGG; sce:YPR013C; -.
DR SGD; S000006217; CMR3.
DR VEuPathDB; FungiDB:YPR013C; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000176618; -.
DR HOGENOM; CLU_957153_0_0_1; -.
DR InParanoid; Q12145; -.
DR OMA; MCTVNYK; -.
DR BioCyc; YEAST:G3O-34174-MON; -.
DR PRO; PR:Q12145; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q12145; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IDA:SGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..317
FT /note="Zinc finger protein CRM3"
FT /id="PRO_0000255974"
FT ZN_FING 254..276
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 282..306
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 317 AA; 35358 MW; F12CF522C7C889FE CRC64;
MNFSLSKQSS EKQSSYTDKS RSPNIGMCTV NYKSNLPLQV SAVDQLSTGK GTQFYGHNSY
KNERECYNST KINLPPISSL LPNFENNTPP NVDSRVQFPP QQVYQSMNVV PIVNEIYTPI
SMNATSDQYP IYYTESQQPI PHSQSPHLTS SAPLMMPVMV PTVYKPLTPY DKEPITIASE
PNFTAISMAS HPNAALELCH DRPKSVPPGY GVLPTMQEAS NGRTKSEPGA VLNGSATFSD
WKTDTRISST KLRKQCPVCG KICSRPSTLK THYLIHTGDT PFKCTWEGCT KSFNVKSNML
RHLKSHERKR NKVLNTT
