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CMR5_ARCFU
ID   CMR5_ARCFU              Reviewed;         155 AA.
AC   O28417;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=CRISPR system Cmr subunit Cmr5;
DE   AltName: Full=CRISPR type III-B/RAMP module-associated protein Cmr5;
GN   Name=cmr5; OrderedLocusNames=AF_1862;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS).
RA   Zhang R., Evdokimova E., Kagan O., Savchenko A., Edwards A., Joachimiak A.;
RT   "The crystal structure of gene product Af1862 from Archaeoglobus
RT   fulgidus.";
RL   Submitted (DEC-2006) to the PDB data bank.
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat), is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain sequences complementary to
CC       antecedent mobile elements and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA). Part of
CC       the Cmr ribonucleoprotein complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISPR system Cmr5 family. {ECO:0000305}.
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DR   EMBL; AE000782; AAB89393.1; -; Genomic_DNA.
DR   PIR; E69482; E69482.
DR   RefSeq; WP_010879355.1; NC_000917.1.
DR   PDB; 2OEB; X-ray; 1.66 A; A=1-155.
DR   PDB; 3X1L; X-ray; 2.10 A; F/G=1-155.
DR   PDBsum; 2OEB; -.
DR   PDBsum; 3X1L; -.
DR   AlphaFoldDB; O28417; -.
DR   SMR; O28417; -.
DR   STRING; 224325.AF_1862; -.
DR   EnsemblBacteria; AAB89393; AAB89393; AF_1862.
DR   GeneID; 24795603; -.
DR   KEGG; afu:AF_1862; -.
DR   eggNOG; arCOG02654; Archaea.
DR   HOGENOM; CLU_120836_0_0_2; -.
DR   OMA; YVKKMPS; -.
DR   OrthoDB; 113767at2157; -.
DR   PhylomeDB; O28417; -.
DR   EvolutionaryTrace; O28417; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.520.30; -; 1.
DR   InterPro; IPR023101; AF1862-like_dom_sf.
DR   InterPro; IPR010160; CRISPR-assoc_prot_Cmr5.
DR   Pfam; PF09701; Cas_Cmr5; 1.
DR   SUPFAM; SSF158568; SSF158568; 1.
DR   TIGRFAMs; TIGR01881; cas_Cmr5; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antiviral defense; Cytoplasm; Reference proteome.
FT   CHAIN           1..155
FT                   /note="CRISPR system Cmr subunit Cmr5"
FT                   /id="PRO_0000418434"
FT   HELIX           3..24
FT                   /evidence="ECO:0007829|PDB:2OEB"
FT   TURN            25..27
FT                   /evidence="ECO:0007829|PDB:2OEB"
FT   HELIX           29..49
FT                   /evidence="ECO:0007829|PDB:2OEB"
FT   HELIX           51..60
FT                   /evidence="ECO:0007829|PDB:2OEB"
FT   HELIX           71..73
FT                   /evidence="ECO:0007829|PDB:2OEB"
FT   HELIX           76..78
FT                   /evidence="ECO:0007829|PDB:2OEB"
FT   STRAND          79..81
FT                   /evidence="ECO:0007829|PDB:2OEB"
FT   HELIX           82..100
FT                   /evidence="ECO:0007829|PDB:2OEB"
FT   HELIX           117..123
FT                   /evidence="ECO:0007829|PDB:2OEB"
FT   HELIX           126..150
FT                   /evidence="ECO:0007829|PDB:2OEB"
SQ   SEQUENCE   155 AA;  17388 MW;  3A367607DBC8497F CRC64;
     MDIREIEQER ASFAFKVVSD IKDKYSQNKK VQGKYSSYAE KAPTIILNNG LGATLAFFLS
     KLEKPIDDVD YKSINPESFG NAENIAYAFL YKHLSTWLAE GNGKDSAFSG LTNGEDPLKY
     IMEKTAIDVA ISTEEALSIL NWIKKFAKAM LEEEL
 
 
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