CMR5_ARCFU
ID CMR5_ARCFU Reviewed; 155 AA.
AC O28417;
DT 05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=CRISPR system Cmr subunit Cmr5;
DE AltName: Full=CRISPR type III-B/RAMP module-associated protein Cmr5;
GN Name=cmr5; OrderedLocusNames=AF_1862;
OS Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS 100126 / VC-16).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=224325;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA Smith H.O., Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS).
RA Zhang R., Evdokimova E., Kagan O., Savchenko A., Edwards A., Joachimiak A.;
RT "The crystal structure of gene product Af1862 from Archaeoglobus
RT fulgidus.";
RL Submitted (DEC-2006) to the PDB data bank.
CC -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC repeat), is an adaptive immune system that provides protection against
CC mobile genetic elements (viruses, transposable elements and conjugative
CC plasmids). CRISPR clusters contain sequences complementary to
CC antecedent mobile elements and target invading nucleic acids. CRISPR
CC clusters are transcribed and processed into CRISPR RNA (crRNA). Part of
CC the Cmr ribonucleoprotein complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CRISPR system Cmr5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000782; AAB89393.1; -; Genomic_DNA.
DR PIR; E69482; E69482.
DR RefSeq; WP_010879355.1; NC_000917.1.
DR PDB; 2OEB; X-ray; 1.66 A; A=1-155.
DR PDB; 3X1L; X-ray; 2.10 A; F/G=1-155.
DR PDBsum; 2OEB; -.
DR PDBsum; 3X1L; -.
DR AlphaFoldDB; O28417; -.
DR SMR; O28417; -.
DR STRING; 224325.AF_1862; -.
DR EnsemblBacteria; AAB89393; AAB89393; AF_1862.
DR GeneID; 24795603; -.
DR KEGG; afu:AF_1862; -.
DR eggNOG; arCOG02654; Archaea.
DR HOGENOM; CLU_120836_0_0_2; -.
DR OMA; YVKKMPS; -.
DR OrthoDB; 113767at2157; -.
DR PhylomeDB; O28417; -.
DR EvolutionaryTrace; O28417; -.
DR Proteomes; UP000002199; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR Gene3D; 1.10.520.30; -; 1.
DR InterPro; IPR023101; AF1862-like_dom_sf.
DR InterPro; IPR010160; CRISPR-assoc_prot_Cmr5.
DR Pfam; PF09701; Cas_Cmr5; 1.
DR SUPFAM; SSF158568; SSF158568; 1.
DR TIGRFAMs; TIGR01881; cas_Cmr5; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antiviral defense; Cytoplasm; Reference proteome.
FT CHAIN 1..155
FT /note="CRISPR system Cmr subunit Cmr5"
FT /id="PRO_0000418434"
FT HELIX 3..24
FT /evidence="ECO:0007829|PDB:2OEB"
FT TURN 25..27
FT /evidence="ECO:0007829|PDB:2OEB"
FT HELIX 29..49
FT /evidence="ECO:0007829|PDB:2OEB"
FT HELIX 51..60
FT /evidence="ECO:0007829|PDB:2OEB"
FT HELIX 71..73
FT /evidence="ECO:0007829|PDB:2OEB"
FT HELIX 76..78
FT /evidence="ECO:0007829|PDB:2OEB"
FT STRAND 79..81
FT /evidence="ECO:0007829|PDB:2OEB"
FT HELIX 82..100
FT /evidence="ECO:0007829|PDB:2OEB"
FT HELIX 117..123
FT /evidence="ECO:0007829|PDB:2OEB"
FT HELIX 126..150
FT /evidence="ECO:0007829|PDB:2OEB"
SQ SEQUENCE 155 AA; 17388 MW; 3A367607DBC8497F CRC64;
MDIREIEQER ASFAFKVVSD IKDKYSQNKK VQGKYSSYAE KAPTIILNNG LGATLAFFLS
KLEKPIDDVD YKSINPESFG NAENIAYAFL YKHLSTWLAE GNGKDSAFSG LTNGEDPLKY
IMEKTAIDVA ISTEEALSIL NWIKKFAKAM LEEEL