ID   CMR5_THEMA              Reviewed;         129 AA.
AC   P58011;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=CRISPR system Cmr subunit Cmr5;
DE   AltName: Full=CRISPR type III-B/RAMP module-associated protein Cmr5;
GN   Name=cmr5; OrderedLocusNames=TM_1791.1;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
RN   [2]
RP   IDENTIFICATION.
RA   Medigue C., Bocs S.;
RL   Unpublished observations (APR-2001).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat), is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain sequences complementary to
CC       antecedent mobile elements and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA). Part of
CC       the Cmr ribonucleoprotein complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISPR system Cmr5 family. {ECO:0000305}.
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DR   EMBL; AE000512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P58011; -.
DR   SMR; P58011; -.
DR   STRING; 243274.THEMA_05235; -.
DR   eggNOG; COG3337; Bacteria.
DR   InParanoid; P58011; -.
DR   OMA; CAKWLKR; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.520.30; -; 1.
DR   InterPro; IPR023101; AF1862-like_dom_sf.
DR   InterPro; IPR010160; CRISPR-assoc_prot_Cmr5.
DR   Pfam; PF09701; Cas_Cmr5; 1.
DR   SUPFAM; SSF158568; SSF158568; 1.
DR   TIGRFAMs; TIGR01881; cas_Cmr5; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytoplasm; Reference proteome.
FT   CHAIN           1..129
FT                   /note="CRISPR system Cmr subunit Cmr5"
FT                   /id="PRO_0000216221"
SQ   SEQUENCE   129 AA;  14572 MW;  7829649FF369F831 CRC64;
     MGTCLEVMKM KTLSLELAKL AMNLVEEVEK DKRDDYLRDV KGLGSMIVQN GLMGTILFLK
     KKGKNKVVDH LGKMIEHLTL EDGIVERLME NEFLDARTYL KAQIAALECA KWLKRCGEVL
     LGGEENETT