CMR5_THET8
ID CMR5_THET8 Reviewed; 114 AA.
AC Q53W05;
DT 05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=CRISPR system Cmr subunit Cmr5;
DE AltName: Full=CRISPR type III-B/RAMP module-associated protein Cmr5;
GN Name=cmr5; OrderedLocusNames=TTHB164;
OS Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OG Plasmid pTT27.
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=300852;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27634 / DSM 579 / HB8;
RA Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT "Complete genome sequence of Thermus thermophilus HB8.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), AND SUBUNIT.
RC STRAIN=ATCC 27634 / DSM 579 / HB8;
RX PubMed=19173314; DOI=10.1002/prot.22358;
RA Sakamoto K., Agari Y., Agari K., Yokoyama S., Kuramitsu S., Shinkai A.;
RT "X-ray crystal structure of a CRISPR-associated RAMP module Cmr5 protein
RT from Thermus thermophilus HB8.";
RL Proteins 75:528-532(2009).
CC -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC repeat), is an adaptive immune system that provides protection against
CC mobile genetic elements (viruses, transposable elements and conjugative
CC plasmids). CRISPR clusters contain sequences complementary to
CC antecedent mobile elements and target invading nucleic acids. CRISPR
CC clusters are transcribed and processed into CRISPR RNA (crRNA). Part of
CC the Cmr ribonucleoprotein complex (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000305|PubMed:19173314}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CRISPR system Cmr5 family. {ECO:0000305}.
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DR EMBL; AP008227; BAD71960.1; -; Genomic_DNA.
DR RefSeq; WP_011229140.1; NC_006462.1.
DR RefSeq; YP_145403.1; NC_006462.1.
DR PDB; 2ZOP; X-ray; 2.10 A; A/B/C/D/E/F=1-114.
DR PDBsum; 2ZOP; -.
DR AlphaFoldDB; Q53W05; -.
DR SMR; Q53W05; -.
DR DIP; DIP-61648N; -.
DR IntAct; Q53W05; 5.
DR EnsemblBacteria; BAD71960; BAD71960; BAD71960.
DR GeneID; 3169607; -.
DR KEGG; ttj:TTHB164; -.
DR PATRIC; fig|300852.9.peg.2113; -.
DR HOGENOM; CLU_120836_2_1_0; -.
DR OMA; EYMLLTR; -.
DR EvolutionaryTrace; Q53W05; -.
DR Proteomes; UP000000532; Plasmid pTT27.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR Gene3D; 1.10.520.30; -; 1.
DR InterPro; IPR023101; AF1862-like_dom_sf.
DR InterPro; IPR010160; CRISPR-assoc_prot_Cmr5.
DR Pfam; PF09701; Cas_Cmr5; 1.
DR SUPFAM; SSF158568; SSF158568; 1.
DR TIGRFAMs; TIGR01881; cas_Cmr5; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antiviral defense; Cytoplasm; Plasmid; Reference proteome.
FT CHAIN 1..114
FT /note="CRISPR system Cmr subunit Cmr5"
FT /id="PRO_0000418435"
FT HELIX 4..19
FT /evidence="ECO:0007829|PDB:2ZOP"
FT HELIX 25..42
FT /evidence="ECO:0007829|PDB:2ZOP"
FT HELIX 44..52
FT /evidence="ECO:0007829|PDB:2ZOP"
FT HELIX 57..69
FT /evidence="ECO:0007829|PDB:2ZOP"
FT HELIX 75..84
FT /evidence="ECO:0007829|PDB:2ZOP"
FT HELIX 87..111
FT /evidence="ECO:0007829|PDB:2ZOP"
SQ SEQUENCE 114 AA; 12961 MW; AB88C368274F6B44 CRC64;
MRTRSQVWAQ KAYEKVREAA KGEGRGEYRD MALKLPVLVR QAGLSQALAF VDSRGKEAHK
ALGNDLAQVL GYRDLRELAE AAREAELLQY LRLTREVLAA AEWFKRFAQA LIEE
