ID   CMR7B_SACS2             Reviewed;         190 AA.
AC   Q97XK8;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Putative CRISPR system CMR subunit Cmr7 2;
GN   Name=cmr7b; OrderedLocusNames=SSO1725;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 2-190, AND SUBUNIT.
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=22227115; DOI=10.1016/j.molcel.2011.12.013;
RA   Zhang J., Rouillon C., Kerou M., Reeks J., Brugger K., Graham S.,
RA   Reimann J., Cannone G., Liu H., Albers S.V., Naismith J.H., Spagnolo L.,
RA   White M.F.;
RT   "Structure and mechanism of the CMR complex for CRISPR-mediated antiviral
RT   immunity.";
RL   Mol. Cell 45:303-313(2012).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305|PubMed:22227115}.
CC   -!- SIMILARITY: Belongs to the CRISPR system Cmr7 family. {ECO:0000305}.
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DR   EMBL; AE006641; AAK41924.1; -; Genomic_DNA.
DR   PIR; E90333; E90333.
DR   RefSeq; WP_010923682.1; NC_002754.1.
DR   PDB; 2XVO; X-ray; 2.08 A; A/B/C/D=3-190.
DR   PDBsum; 2XVO; -.
DR   AlphaFoldDB; Q97XK8; -.
DR   SMR; Q97XK8; -.
DR   STRING; 273057.SSO1725; -.
DR   EnsemblBacteria; AAK41924; AAK41924; SSO1725.
DR   GeneID; 1454703; -.
DR   KEGG; sso:SSO1725; -.
DR   PATRIC; fig|273057.12.peg.1768; -.
DR   HOGENOM; CLU_1425150_0_0_2; -.
DR   EvolutionaryTrace; Q97XK8; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Antiviral defense; Reference proteome.
FT   CHAIN           1..190
FT                   /note="Putative CRISPR system CMR subunit Cmr7 2"
FT                   /id="PRO_0000418084"
FT   STRAND          12..16
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          23..27
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          31..38
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          41..43
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          45..47
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   HELIX           51..53
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          55..58
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   HELIX           59..61
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          63..67
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          70..81
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          84..89
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          96..105
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   HELIX           107..112
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          119..123
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   HELIX           124..126
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          127..130
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          140..145
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          156..158
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          164..169
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   HELIX           179..185
FT                   /evidence="ECO:0007829|PDB:2XVO"
FT   STRAND          187..189
FT                   /evidence="ECO:0007829|PDB:2XVO"
SQ   SEQUENCE   190 AA;  21446 MW;  91925FE7CEE20F3A CRC64;
     MSSPGGSQQV EWVFIPVIKD VTYEFKVDNN DNITELYVNG NKLGPASSLE MDFYFDVDVS
     NNQVRKFNNV FVLFGVIATK DSNKIKMQLT LNPCDFVRGF VFPSQDPSQL NNIFASNNKV
     SVSEKAFAIL NRKKEGAVSS TINVYITQNT YTGNTKIEKI QQNTIIIEKN TGIVFKIPND
     MLNIFRYSTT