ID   CMR_MYCTO               Reviewed;         244 AA.
AC   P9WMH4; F2GK61; L0T8Y5; O53922; Q7D864;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=HTH-type transcriptional regulator Cmr;
GN   Name=cmr; OrderedLocusNames=MT1714;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Positively regulates the expression of at least groEL2.
CC       {ECO:0000250}.
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DR   EMBL; AE000516; AAK45982.1; -; Genomic_DNA.
DR   PIR; F70818; F70818.
DR   RefSeq; WP_003898967.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMH4; -.
DR   SMR; P9WMH4; -.
DR   EnsemblBacteria; AAK45982; AAK45982; MT1714.
DR   KEGG; mtc:MT1714; -.
DR   PATRIC; fig|83331.31.peg.1840; -.
DR   HOGENOM; CLU_075053_10_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00419; HTH_CRP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..244
FT                   /note="HTH-type transcriptional regulator Cmr"
FT                   /id="PRO_0000427303"
FT   DOMAIN          174..237
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   DNA_BIND        197..216
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   BINDING         41..160
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
SQ   SEQUENCE   244 AA;  26793 MW;  D1B3CD2894CD5B69 CRC64;
     MADRSVRPLR HLVHAVTGGQ PPSEAQVRQA AWIARCVGRG GSAPLHRDDV SALAETLQVK
     EFAPGAVVFH ADQTADGVWI VRHGLIELAV GSRRRRAVVN ILHPGDVDGD IPLLLEMPMV
     YTGRALTQAT CLFLDRQAFE RLLATHPAIA RRWLSSVAQR VSTAQIRLMG MLGRPLPAQV
     AQLLLDEAID ARIELAQRTL AAMLGAQRPS INKILKEFER DRLITVGYAV IEITDQHGLR
     ARAQ