ID   CMR_MYCTU               Reviewed;         244 AA.
AC   P9WMH5; F2GK61; L0T8Y5; O53922; Q7D864;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=HTH-type transcriptional regulator Cmr;
GN   Name=cmr; OrderedLocusNames=Rv1675c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [3]
RP   FUNCTION IN TRANSCRIPTION, AND DNA-BINDING.
RX   PubMed=22464736; DOI=10.1016/j.tube.2012.03.001;
RA   Stapleton M.R., Smith L.J., Hunt D.M., Buxton R.S., Green J.;
RT   "Mycobacterium tuberculosis WhiB1 represses transcription of the essential
RT   chaperonin GroEL2.";
RL   Tuberculosis 92:328-332(2012).
CC   -!- FUNCTION: Positively regulates the expression of at least groEL2.
CC       Cyclic AMP does not affect transcription in vitro.
CC       {ECO:0000269|PubMed:22464736}.
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DR   EMBL; AL123456; CCP44440.1; -; Genomic_DNA.
DR   PIR; F70818; F70818.
DR   RefSeq; NP_216191.1; NC_000962.3.
DR   RefSeq; WP_003898967.1; NZ_NVQJ01000010.1.
DR   AlphaFoldDB; P9WMH5; -.
DR   SMR; P9WMH5; -.
DR   STRING; 83332.Rv1675c; -.
DR   PaxDb; P9WMH5; -.
DR   DNASU; 885693; -.
DR   GeneID; 885693; -.
DR   KEGG; mtu:Rv1675c; -.
DR   TubercuList; Rv1675c; -.
DR   eggNOG; COG0664; Bacteria.
DR   OMA; LEMKWKF; -.
DR   PhylomeDB; P9WMH5; -.
DR   PHI-base; PHI:7359; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IDA:MTBBASE.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MTBBASE.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00419; HTH_CRP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..244
FT                   /note="HTH-type transcriptional regulator Cmr"
FT                   /id="PRO_0000420401"
FT   DOMAIN          174..237
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   DNA_BIND        197..216
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   BINDING         41..160
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
SQ   SEQUENCE   244 AA;  26793 MW;  D1B3CD2894CD5B69 CRC64;
     MADRSVRPLR HLVHAVTGGQ PPSEAQVRQA AWIARCVGRG GSAPLHRDDV SALAETLQVK
     EFAPGAVVFH ADQTADGVWI VRHGLIELAV GSRRRRAVVN ILHPGDVDGD IPLLLEMPMV
     YTGRALTQAT CLFLDRQAFE RLLATHPAIA RRWLSSVAQR VSTAQIRLMG MLGRPLPAQV
     AQLLLDEAID ARIELAQRTL AAMLGAQRPS INKILKEFER DRLITVGYAV IEITDQHGLR
     ARAQ