CMS1_HUMAN
ID CMS1_HUMAN Reviewed; 279 AA.
AC Q9BQ75; A8K5S7; B4DUM1; E9PHS3;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Protein CMSS1;
DE AltName: Full=Cms1 ribosomal small subunit homolog;
GN Name=CMSS1; Synonyms=C3orf26;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, Hippocampus, and Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLY-138.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-212, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-167, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- INTERACTION:
CC Q9BQ75; O76024: WFS1; NbExp=3; IntAct=EBI-395649, EBI-720609;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BQ75-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BQ75-2; Sequence=VSP_046688;
CC -!- SIMILARITY: Belongs to the CMS1 family. {ECO:0000305}.
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DR EMBL; AK291392; BAF84081.1; -; mRNA.
DR EMBL; AK300704; BAG62383.1; -; mRNA.
DR EMBL; AK312483; BAG35386.1; -; mRNA.
DR EMBL; AC024938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC069222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC117419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC129803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC130887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006475; AAH06475.1; -; mRNA.
DR EMBL; BC006512; AAH06512.1; -; mRNA.
DR CCDS; CCDS2935.1; -. [Q9BQ75-1]
DR CCDS; CCDS54618.1; -. [Q9BQ75-2]
DR RefSeq; NP_001161396.1; NM_001167924.1. [Q9BQ75-2]
DR RefSeq; NP_115735.2; NM_032359.3. [Q9BQ75-1]
DR AlphaFoldDB; Q9BQ75; -.
DR SMR; Q9BQ75; -.
DR BioGRID; 124045; 144.
DR IntAct; Q9BQ75; 32.
DR MINT; Q9BQ75; -.
DR STRING; 9606.ENSP00000410396; -.
DR GlyGen; Q9BQ75; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BQ75; -.
DR PhosphoSitePlus; Q9BQ75; -.
DR SwissPalm; Q9BQ75; -.
DR BioMuta; CMSS1; -.
DR DMDM; 215274008; -.
DR EPD; Q9BQ75; -.
DR jPOST; Q9BQ75; -.
DR MassIVE; Q9BQ75; -.
DR MaxQB; Q9BQ75; -.
DR PaxDb; Q9BQ75; -.
DR PeptideAtlas; Q9BQ75; -.
DR PRIDE; Q9BQ75; -.
DR ProteomicsDB; 20593; -.
DR ProteomicsDB; 78639; -. [Q9BQ75-1]
DR Antibodypedia; 50471; 42 antibodies from 11 providers.
DR DNASU; 84319; -.
DR Ensembl; ENST00000421999.8; ENSP00000410396.2; ENSG00000184220.12. [Q9BQ75-1]
DR Ensembl; ENST00000489081.5; ENSP00000419161.1; ENSG00000184220.12. [Q9BQ75-2]
DR GeneID; 84319; -.
DR KEGG; hsa:84319; -.
DR MANE-Select; ENST00000421999.8; ENSP00000410396.2; NM_032359.4; NP_115735.2.
DR UCSC; uc003dtl.4; human. [Q9BQ75-1]
DR CTD; 84319; -.
DR DisGeNET; 84319; -.
DR GeneCards; CMSS1; -.
DR HGNC; HGNC:28666; CMSS1.
DR HPA; ENSG00000184220; Low tissue specificity.
DR neXtProt; NX_Q9BQ75; -.
DR OpenTargets; ENSG00000184220; -.
DR PharmGKB; PA142672387; -.
DR VEuPathDB; HostDB:ENSG00000184220; -.
DR eggNOG; KOG3089; Eukaryota.
DR GeneTree; ENSGT00390000006574; -.
DR InParanoid; Q9BQ75; -.
DR OMA; QKQRGIF; -.
DR OrthoDB; 1520704at2759; -.
DR PhylomeDB; Q9BQ75; -.
DR TreeFam; TF329710; -.
DR PathwayCommons; Q9BQ75; -.
DR SignaLink; Q9BQ75; -.
DR BioGRID-ORCS; 84319; 15 hits in 1075 CRISPR screens.
DR ChiTaRS; CMSS1; human.
DR GenomeRNAi; 84319; -.
DR Pharos; Q9BQ75; Tdark.
DR PRO; PR:Q9BQ75; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9BQ75; protein.
DR Bgee; ENSG00000184220; Expressed in tibialis anterior and 180 other tissues.
DR ExpressionAtlas; Q9BQ75; baseline and differential.
DR Genevisible; Q9BQ75; HS.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR032704; Cms1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24030; PTHR24030; 1.
DR Pfam; PF14617; CMS1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..279
FT /note="Protein CMSS1"
FT /id="PRO_0000239014"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5FVR6"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5FVR6"
FT MOD_RES 167
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 212
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT VAR_SEQ 1..21
FT /note="MADDLGDEWWENQPTGAGSSP -> MHG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046688"
FT VARIANT 138
FT /note="E -> G (in dbSNP:rs11537817)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_047645"
FT VARIANT 166
FT /note="V -> I (in dbSNP:rs11537816)"
FT /id="VAR_033658"
FT CONFLICT 75
FT /note="K -> E (in Ref. 1; BAG62383)"
FT /evidence="ECO:0000305"
FT CONFLICT 249..250
FT /note="DI -> GV (in Ref. 1; BAG62383)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 279 AA; 31884 MW; B0FE22D1A88CF1C9 CRC64;
MADDLGDEWW ENQPTGAGSS PEASDGEGEG DTEVMQQETV PVPVPSEKTK QPKECFLIQP
KERKENTTKT RKRRKKKITD VLAKSEPKPG LPEDLQKLMK DYYSSRRLVI ELEELNLPDS
CFLKANDLTH SLSSYLKEIC PKWVKLRKNH SEKKSVLMLI ICSSAVRALE LIRSMTAFRG
DGKVIKLFAK HIKVQAQVKL LEKRVVHLGV GTPGRIKELV KQGGLNLSPL KFLVFDWNWR
DQKLRRMMDI PEIRKEVFEL LEMGVLSLCK SESLKLGLF
