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CMT1_ORYSJ
ID   CMT1_ORYSJ              Reviewed;        1059 AA.
AC   A0A0P0VUY4; C0SQ90; Q0DTT2; Q8H854;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2016, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=DNA (cytosine-5)-methyltransferase CMT1 {ECO:0000305};
DE            EC=2.1.1.37 {ECO:0000305};
DE   AltName: Full=Chromomethylase 1 {ECO:0000305};
DE   AltName: Full=OsMET3b {ECO:0000303|PubMed:26243209};
GN   Name=CMT1 {ECO:0000305};
GN   OrderedLocusNames=Os03g0226800 {ECO:0000312|EMBL:BAS83066.1},
GN   LOC_Os03g12570 {ECO:0000312|EMBL:ABF94750.1};
GN   ORFNames=OJ1626B05.3 {ECO:0000312|EMBL:AAN60988.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 309-998, FUNCTION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=26243209; DOI=10.1111/tpj.12952;
RA   Cheng C., Tarutani Y., Miyao A., Ito T., Yamazaki M., Sakai H., Fukai E.,
RA   Hirochika H.;
RT   "Loss of function mutations in the rice chromomethylase OsCMT3a cause a
RT   burst of transposition.";
RL   Plant J. 83:1069-1081(2015).
CC   -!- FUNCTION: Involved in CpXpG DNA methylation (By similarity). May not
CC       play a major role in maintaining CpXpG methylation (Probable).
CC       {ECO:0000250|UniProtKB:C0SQ89, ECO:0000305|PubMed:26243209}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC         methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC         Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions. {ECO:0000269|PubMed:26243209}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. C5-methyltransferase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01016}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAF11356.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAS83066.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC104473; AAN60988.1; -; Genomic_DNA.
DR   EMBL; DP000009; ABF94750.1; -; Genomic_DNA.
DR   EMBL; AP008209; BAF11356.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014959; BAS83066.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AB360584; BAH37020.1; -; Genomic_DNA.
DR   RefSeq; XP_015630016.1; XM_015774530.1.
DR   AlphaFoldDB; A0A0P0VUY4; -.
DR   SMR; A0A0P0VUY4; -.
DR   STRING; 4530.OS03T0226800-01; -.
DR   REBASE; 11925; M.OsaCMT3P.
DR   PaxDb; A0A0P0VUY4; -.
DR   EnsemblPlants; Os03t0226800-01; Os03t0226800-01; Os03g0226800.
DR   GeneID; 4332128; -.
DR   Gramene; Os03t0226800-01; Os03t0226800-01; Os03g0226800.
DR   KEGG; osa:4332128; -.
DR   eggNOG; ENOG502QW29; Eukaryota.
DR   OMA; CRIVEFF; -.
DR   OrthoDB; 898916at2759; -.
DR   BRENDA; 2.1.1.37; 4460.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.30.490; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR043151; BAH_sf.
DR   InterPro; IPR018117; C5_DNA_meth_AS.
DR   InterPro; IPR001525; C5_MeTfrase.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR   InterPro; IPR023780; Chromo_domain.
DR   InterPro; IPR023779; Chromodomain_CS.
DR   InterPro; IPR017198; DNMT1-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF01426; BAH; 1.
DR   Pfam; PF00385; Chromo; 1.
DR   Pfam; PF00145; DNA_methylase; 1.
DR   PIRSF; PIRSF037404; DNMT1; 1.
DR   PRINTS; PR00105; C5METTRFRASE.
DR   SMART; SM00439; BAH; 1.
DR   SMART; SM00298; CHROMO; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   SUPFAM; SSF54160; SSF54160; 1.
DR   PROSITE; PS51038; BAH; 1.
DR   PROSITE; PS00094; C5_MTASE_1; 1.
DR   PROSITE; PS00598; CHROMO_1; 1.
DR   PROSITE; PS50013; CHROMO_2; 1.
DR   PROSITE; PS51679; SAM_MT_C5; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..1059
FT                   /note="DNA (cytosine-5)-methyltransferase CMT1"
FT                   /id="PRO_0000438156"
FT   DOMAIN          312..436
FT                   /note="BAH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00370"
FT   DOMAIN          479..1017
FT                   /note="SAM-dependent MTase C5-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01016"
FT   DOMAIN          584..649
FT                   /note="Chromo"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00053"
FT   REGION          1..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..133
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        662
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01016"
SQ   SEQUENCE   1059 AA;  118880 MW;  7D30E862B60BDE48 CRC64;
     MVPEPAPAAA TEPRRSTRRR LMTAAAMEAE AEAVADLDEI DREMSRAESR KRQRRTAKEK
     PGARKGATEW KPEDVEKAAA AEGVAELDEI DREMPRPELR KRQRRTAKEK PSAHEGATEW
     KPEDVEKAAA QEPEGTELDS GLSPAESRGK RQRGVEKVKR RTRKKTAKEK TKETTEKSAA
     QAPEKMKVND AGGALAEDVC ADEPDAEQMA MEEEEEAADV LEAEERMGKC VGEGSAEKAA
     TRKRVARPST ARRVEDSDDH FVGDPVPDDE ARQRWPVRYS RKGSDSLLKQ EPDEDEEMKA
     RCHYLAANVD DEIYHLDDDV YVKAGPDEEN YIGRITEFFE GVDRGSYFSC QWFFRTADTV
     ISSKLLKVHD HRHNHKRVFL SKEKNDNLIE CIVSKVKIAH VDPNMTPQAR AHAISDCDLY
     YDMSYSVAYS TFANLPADND GALGSEATSN ISCDDADNSS KGKLSADIVA PYSEQTETAS
     LLDLYSGCGA MSTGLCLGFA FSGINLETRW AVDINKYACA CLKHNHPYSQ VRNEKTEDFL
     ALIQQWDALC RKYVVHKNDT LEPSIDMPLN DADDVNEPLP EDIFDVEELL EICYGDPSNT
     GKNGLWFKVR WKGYDPSYDT WEPIDGLSDC PERIKEFVEK GHKENILPLP GAVDVICGGP
     PCQGISGFNR FRKHNDPLED EKNKQLVVFM DIVKYLRPKY VLMENVVDIL KFADGFLGRY
     AMSCLVAMNY QARLGMMAAG YYGLPQFRMR AFLWGALPSM VLPKFPLPTH DAVVRGIVPT
     TFSQSVVAYN EVDTRCLRKA LLLADAISDL PKVGNDQPKD VIEYSVAPKT EFQRYIRNNR
     KDIQDYSFRG DDPSEEGKLF DHQPLKLNKD DYERVQRIPV KKGANFRDLK GVIVGPDNTV
     RLDPNISRER LSSGKPLVPD YAISFVKGKS TKPFGRLWWD ETVPTVVTRA EPHNQIILHP
     SQDRVLTIRE NARLQGFPDY YRLIGPLKEK YIQVGNAVAI PVARALGYAL GLAYRGESDG
     DRAVLKLPES FIYADQETVV KSSAGTPGSE IADSEQLFE
 
 
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