CMTA1_CAEEL
ID CMTA1_CAEEL Reviewed; 1185 AA.
AC H2KY84; H2KY85; Q629J3;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Calmodulin-binding transcription activator homolog 1 {ECO:0000305};
GN Name=camt-1 {ECO:0000312|WormBase:T05C1.4a};
GN ORFNames=T05C1.4 {ECO:0000312|WormBase:T05C1.4a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN, AND MUTAGENESIS
RP OF 142-GLY-LYS-143; 175-ARG-ARG-176; 189-VAL--LEU-192 AND
RP 631-ARG--ALA-1185.
RX PubMed=34499028; DOI=10.7554/elife.68238;
RA Vuong-Brender T.T., Flynn S., Vallis Y., de Bono M.;
RT "Neuronal calmodulin levels are controlled by CAMTA transcription
RT factors.";
RL Elife 10:0-0(2021).
CC -!- FUNCTION: Transcription factor (PubMed:34499028). Positively modulates
CC neuronal levels of the ubiquitous Ca2+ sensor calmodulin/cmd-1,
CC probably by direct binding to the cmd-1 promoter, thereby regulating
CC Ca2+ signaling, physiology, and behavior (PubMed:34499028).
CC {ECO:0000269|PubMed:34499028}.
CC -!- SUBUNIT: May interact with calmodulin. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:34499028}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a {ECO:0000312|WormBase:T05C1.4a};
CC IsoId=H2KY84-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:T05C1.4b};
CC IsoId=H2KY84-2; Sequence=VSP_061379, VSP_061380;
CC Name=c {ECO:0000312|WormBase:T05C1.4c};
CC IsoId=H2KY84-3; Sequence=VSP_061378, VSP_061379, VSP_061380;
CC -!- TISSUE SPECIFICITY: Expressed broadly in the nervous system.
CC {ECO:0000269|PubMed:34499028}.
CC -!- DOMAIN: May negatively modulate calmodulin/cmd-1 expression via a
CC negative feedback loop in which the IQ domains bind to calmodulin.
CC {ECO:0000269|PubMed:34499028}.
CC -!- SIMILARITY: Belongs to the CAMTA family. {ECO:0000305}.
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DR EMBL; BX284602; CCD61745.1; -; Genomic_DNA.
DR EMBL; BX284602; CCD61746.1; -; Genomic_DNA.
DR EMBL; BX284602; CCD61747.1; -; Genomic_DNA.
DR RefSeq; NP_494795.2; NM_062394.4.
DR AlphaFoldDB; H2KY84; -.
DR SMR; H2KY84; -.
DR STRING; 6239.T05C1.4a; -.
DR PaxDb; H2KY84; -.
DR PeptideAtlas; H2KY84; -.
DR EnsemblMetazoa; T05C1.4a.1; T05C1.4a.1; WBGene00020251. [H2KY84-1]
DR EnsemblMetazoa; T05C1.4b.1; T05C1.4b.1; WBGene00020251. [H2KY84-2]
DR EnsemblMetazoa; T05C1.4c.1; T05C1.4c.1; WBGene00020251. [H2KY84-3]
DR GeneID; 173786; -.
DR KEGG; cel:CELE_T05C1.4; -.
DR CTD; 173786; -.
DR WormBase; T05C1.4a; CE33443; WBGene00020251; camt-1.
DR WormBase; T05C1.4b; CE33444; WBGene00020251; camt-1.
DR WormBase; T05C1.4c; CE32207; WBGene00020251; camt-1.
DR eggNOG; KOG0520; Eukaryota.
DR GeneTree; ENSGT00940000165359; -.
DR HOGENOM; CLU_1157312_0_0_1; -.
DR InParanoid; H2KY84; -.
DR OMA; DANHIGT; -.
DR OrthoDB; 315169at2759; -.
DR PhylomeDB; H2KY84; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00020251; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; H2KY84; baseline and differential.
DR GO; GO:0000785; C:chromatin; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; IDA:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0050918; P:positive chemotaxis; IGI:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0070482; P:response to oxygen levels; IGI:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005559; CG-1_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF03859; CG-1; 1.
DR SMART; SM01076; CG-1; 1.
DR SMART; SM00015; IQ; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS51437; CG_1; 1.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; ANK repeat; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..1185
FT /note="Calmodulin-binding transcription activator homolog
FT 1"
FT /id="PRO_0000454731"
FT DOMAIN 418..498
FT /note="IPT/TIG"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6Y1"
FT REPEAT 616..646
FT /note="ANK"
FT /evidence="ECO:0000255"
FT DOMAIN 957..984
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DNA_BIND 72..200
FT /note="CG-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00767"
FT REGION 252..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..948
FT /note="MNNSVTRLLFKRLLTLQLCHHFDIIPHRDQSFDCVQMQQPQNETANNFIPSI
FT QLLWSTDPPQIRPDGTYPQAVELFPCFKDKWNTKEEILNIILAANADPKSNCVTVQSSP
FT RPCSSSQFIYPRLDNAWYKNDGYIWKKRTNGKQNREDHLNLKISGHPHISAKYIHSAIV
FT PTFHRRSYSVPDSDCHVLVHYLNVKTNNKIDDQAEEIARSMIENKVFISLSQLHDQLSP
FT IFLQTLNVNQLVAEINEHLKKKGVNLPTSPLPQEPSSSTSRELERRNSCSSAFRKGLSS
FT VALRRQPSANSEIDANHIGTMLKRFGCNGSSSDRISIIQPTMQNFQSIRSHQNHVAMES
FT RSPSGDGDSRPITFEEDASYQQLSIKSSTNVSTPASAFAEKMKIRSGSQESPMGPPSSS
FT SVTSTSLIPIIEMTPSSSSLKGGQKMLVVGGYYRKGHEYKISFGRGRMMPAVLIHAGVL
FT SCVIPPSAKPEVVQIRVFCNGQAISTASEFTYEPQSAHLIKENDDTLVQIFEKIRIMAC
FT AFNAYSSIENIQSSSCMESLLANIVQQIDNEVSSQNLNYKTELLNGSAHFPSKTVLHLV
FT ASLDYDRLFEALIDLSRKVPACREFDIFARDNDGSTPLHTACKNSASRIARLIISIDSS
FT AIDVVDDRGRTPVEVAPEHSIDMLSDKNNEEERVNATELWVMTNGKAFTTDKILDGKIS
FT RAPIAEKPDDLLREATSSYSIMSEMYEGPMLQAGTSRECDEDCESCCDPDSTQQLHVEI
FT AMDTDVHVPDSPKMARLFHAVTSPGIVVPPNARARMADLARQIIEALPDRIKRNSEVSM
FT CPDEEDPGQNHHGGVEPMFYQQASCSMSTDSPNMMDDYFDMMATETRNDIFTEPRSTET
FT TETSASKSAQLFATHCNFFDDRSFASSSTRANTFESDTLDFDKDLGEFFTIHVDRFVDP
FT IQQRLANLKYN -> MVYSQLNPKRSALDADDHLLYRGFC (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_061378"
FT VAR_SEQ 1095..1163
FT /note="NVNIDDGHTQHLIAENACAKRRRYVACPQTSGDQRNKRDSDGERKRDAHHDA
FT PEFIPIGATPSSTTIPH -> KLRKMHALNEDGTSPARKPAEINATNEILMVNGKEMLT
FT TMPQNSFRSVQHHPQQQFHIDQHNVIIHGTN (in isoform b and isoform
FT c)"
FT /evidence="ECO:0000305"
FT /id="VSP_061379"
FT VAR_SEQ 1164..1185
FT /note="Missing (in isoform b and isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_061380"
FT MUTAGEN 142..143
FT /note="GK->AA: In db1258; defects in aggregation behavior
FT (feeding in groups) and O2-response, in a npr-1 mutant
FT background."
FT /evidence="ECO:0000269|PubMed:34499028"
FT MUTAGEN 175..176
FT /note="RR->AA: In db1259; defects in aggregation behavior
FT (feeding in groups) and O2-response, in a npr-1 mutant
FT background."
FT /evidence="ECO:0000269|PubMed:34499028"
FT MUTAGEN 189..192
FT /note="VHYL->APAA: In db1260; defects in aggregation
FT behavior (feeding in groups) and O2-response, in a npr-1
FT mutant background."
FT /evidence="ECO:0000269|PubMed:34499028"
FT MUTAGEN 631..1185
FT /note="Missing: In db973; increased turning frequency both
FT in the presence and absence of a CO2 stimulus. BAG CO2
FT sensor neurons have higher Ca2+ baselines and Ca2+
FT responses. In an npr-1 mutant background, has pleiotropic
FT behavioral defects and reduced expression of
FT calmodulin/cmd-1 in several types of neurons."
FT /evidence="ECO:0000269|PubMed:34499028"
SQ SEQUENCE 1185 AA; 133586 MW; D8EF18E9C64C97E4 CRC64;
MNNSVTRLLF KRLLTLQLCH HFDIIPHRDQ SFDCVQMQQP QNETANNFIP SIQLLWSTDP
PQIRPDGTYP QAVELFPCFK DKWNTKEEIL NIILAANADP KSNCVTVQSS PRPCSSSQFI
YPRLDNAWYK NDGYIWKKRT NGKQNREDHL NLKISGHPHI SAKYIHSAIV PTFHRRSYSV
PDSDCHVLVH YLNVKTNNKI DDQAEEIARS MIENKVFISL SQLHDQLSPI FLQTLNVNQL
VAEINEHLKK KGVNLPTSPL PQEPSSSTSR ELERRNSCSS AFRKGLSSVA LRRQPSANSE
IDANHIGTML KRFGCNGSSS DRISIIQPTM QNFQSIRSHQ NHVAMESRSP SGDGDSRPIT
FEEDASYQQL SIKSSTNVST PASAFAEKMK IRSGSQESPM GPPSSSSVTS TSLIPIIEMT
PSSSSLKGGQ KMLVVGGYYR KGHEYKISFG RGRMMPAVLI HAGVLSCVIP PSAKPEVVQI
RVFCNGQAIS TASEFTYEPQ SAHLIKENDD TLVQIFEKIR IMACAFNAYS SIENIQSSSC
MESLLANIVQ QIDNEVSSQN LNYKTELLNG SAHFPSKTVL HLVASLDYDR LFEALIDLSR
KVPACREFDI FARDNDGSTP LHTACKNSAS RIARLIISID SSAIDVVDDR GRTPVEVAPE
HSIDMLSDKN NEEERVNATE LWVMTNGKAF TTDKILDGKI SRAPIAEKPD DLLREATSSY
SIMSEMYEGP MLQAGTSREC DEDCESCCDP DSTQQLHVEI AMDTDVHVPD SPKMARLFHA
VTSPGIVVPP NARARMADLA RQIIEALPDR IKRNSEVSMC PDEEDPGQNH HGGVEPMFYQ
QASCSMSTDS PNMMDDYFDM MATETRNDIF TEPRSTETTE TSASKSAQLF ATHCNFFDDR
SFASSSTRAN TFESDTLDFD KDLGEFFTIH VDRFVDPIQQ RLANLKYNDD EQRDVYEAAM
VIQRAYRVYR ARSTTRRQED IERRAALKIQ GCYRRYKQFC YFKKLHNAAI VVQKHFRMRK
RDDKEEGAVE AVIASVPEHP TLDGQSICIQ VPKTNSTMLR ERAATTIQVA YRYRHRKRQA
AARKIQNFMR QNRNNVNIDD GHTQHLIAEN ACAKRRRYVA CPQTSGDQRN KRDSDGERKR
DAHHDAPEFI PIGATPSSTT IPHRPTQRHH PWDQLKPPYG CGTLA
