CMTA1_MOUSE
ID CMTA1_MOUSE Reviewed; 1682 AA.
AC A2A891; A2A892; A2A896; A2A897; A2A898; B2KGR3; B2KGR4; Q80TQ8;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Calmodulin-binding transcription activator 1 {ECO:0000312|EMBL:CAM24783.1};
GN Name=Camta1 {ECO:0000312|MGI:MGI:2140230};
GN Synonyms=Kiaa0833 {ECO:0000312|EMBL:BAC65665.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAC65665.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-1682 (ISOFORM 1).
RC TISSUE=Brain {ECO:0000312|EMBL:BAC65665.1};
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
CC -!- FUNCTION: Transcriptional activator. {ECO:0000250}.
CC -!- SUBUNIT: May interact with calmodulin. {ECO:0000250|UniProtKB:Q9Y6Y1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y6Y1,
CC ECO:0000255|PROSITE-ProRule:PRU00767}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9Y6Y1}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1 {ECO:0000269|PubMed:12693553};
CC IsoId=A2A891-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2A891-2; Sequence=VSP_052990;
CC Name=3;
CC IsoId=A2A891-3; Sequence=VSP_052987, VSP_052988;
CC Name=4;
CC IsoId=A2A891-4; Sequence=VSP_052987, VSP_052988, VSP_052990,
CC VSP_052991;
CC Name=5;
CC IsoId=A2A891-5; Sequence=VSP_052989, VSP_052990, VSP_052991;
CC -!- SIMILARITY: Belongs to the CAMTA family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM24788.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL606986; CAM18834.1; -; Genomic_DNA.
DR EMBL; AL606967; CAM18834.1; JOINED; Genomic_DNA.
DR EMBL; AL607143; CAM18834.1; JOINED; Genomic_DNA.
DR EMBL; AL611931; CAM18834.1; JOINED; Genomic_DNA.
DR EMBL; AL732550; CAM18834.1; JOINED; Genomic_DNA.
DR EMBL; AL606986; CAM18835.1; -; Genomic_DNA.
DR EMBL; AL606967; CAM18835.1; JOINED; Genomic_DNA.
DR EMBL; AL607143; CAM18835.1; JOINED; Genomic_DNA.
DR EMBL; AL611931; CAM18835.1; JOINED; Genomic_DNA.
DR EMBL; AL732550; CAM18835.1; JOINED; Genomic_DNA.
DR EMBL; AL606967; CAM20269.1; -; Genomic_DNA.
DR EMBL; AL606986; CAM20269.1; JOINED; Genomic_DNA.
DR EMBL; AL607143; CAM20269.1; JOINED; Genomic_DNA.
DR EMBL; AL611931; CAM20269.1; JOINED; Genomic_DNA.
DR EMBL; AL732550; CAM20269.1; JOINED; Genomic_DNA.
DR EMBL; AL606967; CAM20270.1; -; Genomic_DNA.
DR EMBL; AL606986; CAM20270.1; JOINED; Genomic_DNA.
DR EMBL; AL607143; CAM20270.1; JOINED; Genomic_DNA.
DR EMBL; AL611931; CAM20270.1; JOINED; Genomic_DNA.
DR EMBL; AL732550; CAM20270.1; JOINED; Genomic_DNA.
DR EMBL; AL732550; CAM24365.1; -; Genomic_DNA.
DR EMBL; AL606967; CAM24365.1; JOINED; Genomic_DNA.
DR EMBL; AL606986; CAM24365.1; JOINED; Genomic_DNA.
DR EMBL; AL607143; CAM24365.1; JOINED; Genomic_DNA.
DR EMBL; AL611931; CAM24365.1; JOINED; Genomic_DNA.
DR EMBL; AL732550; CAM24366.1; -; Genomic_DNA.
DR EMBL; AL606967; CAM24366.1; JOINED; Genomic_DNA.
DR EMBL; AL606986; CAM24366.1; JOINED; Genomic_DNA.
DR EMBL; AL607143; CAM24366.1; JOINED; Genomic_DNA.
DR EMBL; AL611931; CAM24366.1; JOINED; Genomic_DNA.
DR EMBL; AL607143; CAM24783.1; -; Genomic_DNA.
DR EMBL; AL606967; CAM24783.1; JOINED; Genomic_DNA.
DR EMBL; AL606986; CAM24783.1; JOINED; Genomic_DNA.
DR EMBL; AL611931; CAM24783.1; JOINED; Genomic_DNA.
DR EMBL; AL732550; CAM24783.1; JOINED; Genomic_DNA.
DR EMBL; AL607143; CAM24784.1; -; Genomic_DNA.
DR EMBL; AL606967; CAM24784.1; JOINED; Genomic_DNA.
DR EMBL; AL606986; CAM24784.1; JOINED; Genomic_DNA.
DR EMBL; AL611931; CAM24784.1; JOINED; Genomic_DNA.
DR EMBL; AL732550; CAM24784.1; JOINED; Genomic_DNA.
DR EMBL; AL607143; CAM24788.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AL607143; CAM24789.1; -; Genomic_DNA.
DR EMBL; AL607143; CAM24790.1; -; Genomic_DNA.
DR EMBL; AL611931; CAM25054.1; -; Genomic_DNA.
DR EMBL; AL606967; CAM25054.1; JOINED; Genomic_DNA.
DR EMBL; AL606986; CAM25054.1; JOINED; Genomic_DNA.
DR EMBL; AL607143; CAM25054.1; JOINED; Genomic_DNA.
DR EMBL; AL732550; CAM25054.1; JOINED; Genomic_DNA.
DR EMBL; AL611931; CAM25055.1; -; Genomic_DNA.
DR EMBL; AL606967; CAM25055.1; JOINED; Genomic_DNA.
DR EMBL; AL606986; CAM25055.1; JOINED; Genomic_DNA.
DR EMBL; AL607143; CAM25055.1; JOINED; Genomic_DNA.
DR EMBL; AL732550; CAM25055.1; JOINED; Genomic_DNA.
DR EMBL; CU442759; CAQ51627.1; -; Genomic_DNA.
DR EMBL; CU207342; CAQ51627.1; JOINED; Genomic_DNA.
DR EMBL; CU407306; CAQ51627.1; JOINED; Genomic_DNA.
DR EMBL; CU442759; CAQ51628.1; -; Genomic_DNA.
DR EMBL; CU207342; CAQ51628.1; JOINED; Genomic_DNA.
DR EMBL; CU407306; CAQ51628.1; JOINED; Genomic_DNA.
DR EMBL; CU407306; CAQ51883.1; -; Genomic_DNA.
DR EMBL; CU207342; CAQ51883.1; JOINED; Genomic_DNA.
DR EMBL; CU442759; CAQ51883.1; JOINED; Genomic_DNA.
DR EMBL; CU407306; CAQ51884.1; -; Genomic_DNA.
DR EMBL; CU207342; CAQ51884.1; JOINED; Genomic_DNA.
DR EMBL; CU442759; CAQ51884.1; JOINED; Genomic_DNA.
DR EMBL; AK122383; BAC65665.1; -; mRNA.
DR CCDS; CCDS38981.1; -. [A2A891-1]
DR RefSeq; NP_001075026.1; NM_001081557.3. [A2A891-1]
DR AlphaFoldDB; A2A891; -.
DR SMR; A2A891; -.
DR IntAct; A2A891; 1.
DR STRING; 10090.ENSMUSP00000054804; -.
DR iPTMnet; A2A891; -.
DR PhosphoSitePlus; A2A891; -.
DR MaxQB; A2A891; -.
DR PaxDb; A2A891; -.
DR PRIDE; A2A891; -.
DR ProteomicsDB; 283639; -. [A2A891-1]
DR ProteomicsDB; 283640; -. [A2A891-2]
DR ProteomicsDB; 283641; -. [A2A891-3]
DR ProteomicsDB; 283642; -. [A2A891-4]
DR ProteomicsDB; 283643; -. [A2A891-5]
DR Antibodypedia; 49059; 69 antibodies from 18 providers.
DR Ensembl; ENSMUST00000049790; ENSMUSP00000054804; ENSMUSG00000014592. [A2A891-1]
DR Ensembl; ENSMUST00000097774; ENSMUSP00000095381; ENSMUSG00000014592. [A2A891-2]
DR Ensembl; ENSMUST00000105668; ENSMUSP00000101293; ENSMUSG00000014592. [A2A891-3]
DR Ensembl; ENSMUST00000105670; ENSMUSP00000101295; ENSMUSG00000014592. [A2A891-4]
DR Ensembl; ENSMUST00000169423; ENSMUSP00000127916; ENSMUSG00000014592. [A2A891-1]
DR GeneID; 100072; -.
DR KEGG; mmu:100072; -.
DR UCSC; uc008vyk.2; mouse. [A2A891-4]
DR UCSC; uc008vym.2; mouse. [A2A891-3]
DR UCSC; uc008vyn.2; mouse. [A2A891-1]
DR CTD; 23261; -.
DR MGI; MGI:2140230; Camta1.
DR VEuPathDB; HostDB:ENSMUSG00000014592; -.
DR eggNOG; KOG0520; Eukaryota.
DR GeneTree; ENSGT00940000155203; -.
DR HOGENOM; CLU_003170_1_0_1; -.
DR InParanoid; A2A891; -.
DR OMA; CSPQQGG; -.
DR OrthoDB; 315169at2759; -.
DR PhylomeDB; A2A891; -.
DR TreeFam; TF323452; -.
DR BioGRID-ORCS; 100072; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Camta1; mouse.
DR PRO; PR:A2A891; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2A891; protein.
DR Bgee; ENSMUSG00000014592; Expressed in ventromedial nucleus of hypothalamus and 226 other tissues.
DR ExpressionAtlas; A2A891; baseline and differential.
DR Genevisible; A2A891; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
DR GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; ISO:MGI.
DR GO; GO:0035307; P:positive regulation of protein dephosphorylation; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039033; Camta1.
DR InterPro; IPR005559; CG-1_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR23335:SF11; PTHR23335:SF11; 1.
DR Pfam; PF03859; CG-1; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM01076; CG-1; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51437; CG_1; 1.
DR PROSITE; PS50096; IQ; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; ANK repeat; Cytoplasm; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..1682
FT /note="Calmodulin-binding transcription activator 1"
FT /id="PRO_0000355043"
FT DOMAIN 877..955
FT /note="IPT/TIG"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6Y1"
FT REPEAT 1066..1095
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 1111..1141
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REPEAT 1145..1174
FT /note="ANK 3"
FT /evidence="ECO:0000255"
FT DOMAIN 1549..1585
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1586..1608
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1609..1631
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DNA_BIND 63..188
FT /note="CG-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00767"
FT REGION 284..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1267..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 112..119
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6Y1,
FT ECO:0000255|PROSITE-ProRule:PRU00767"
FT COMPBIAS 305..331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..978
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_052987"
FT VAR_SEQ 1222..1334
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_052988"
FT VAR_SEQ 1459..1472
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_052989"
FT VAR_SEQ 1566..1572
FT /note="Missing (in isoform 2, isoform 4 and isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_052990"
FT VAR_SEQ 1662..1682
FT /note="SPLVDHRLYKRSERIEKGQGT -> RVKELKKAKELEDIQQHPLAM (in
FT isoform 4 and isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_052991"
FT CONFLICT 1394
FT /note="D -> G (in Ref. 1; CAQ51627/CAQ51628/CAQ51883/
FT CAQ51884)"
FT /evidence="ECO:0000305"
FT CONFLICT 1482
FT /note="S -> N (in Ref. 1; CAQ51627/CAQ51628/CAQ51883/
FT CAQ51884)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1682 AA; 184319 MW; 3F96253C6CF119C6 CRC64;
MWRAEGKWLP KTSRKSVSQS VFCGTSTYCV LNTVPPIEDD HGNSNSSHVK IFLPKKLLEC
LPKCSSLPKE RHRWNTNEEI AAYLITFEKH EEWLTTSPKT RPQNGSMILY NRKKVKYRKD
GYCWKKRKDG KTTREDHMKL KVQGVECLYG CYVHSSIIPT FHRRCYWLLQ NPDIVLVHYL
NVPAIEDCGK PCGPILCSIN TDKKEWAKWT KEELIGQLKP MFHGIKWTCS NGNSSSGFSV
EQLVQQILDS HQTKPQPRTH NCLCTGSLGA GSSVHHKCNS AKHRIISPKV EPRAGGYGGH
SEVQHNDVSE GKHEPSHGRS TSREKRNGKV AKPALLHQNS TEVSSTNQVE VPDTTQSSPV
SISSGLNSDP DMVDSPVVTG VSSMAVASVM GGLSQSATVF MSEVTNEAVY TMSPTAGPNH
HLLSPDASQG LVLAVSSDGH KFAFPTTGSS DSLSMLPANV SEELVLSTTL DGGRKIPETA
MNFDPDCFLN NPKQGQTYGG GGLKAEMVST NIRHSPPAER SFGFTSVLTK EIKTEDTSFE
QQMAKEAAYS SSAAAAASSS LTLTAAGSSL LPSGGGLSPS TTLEQMDFSA IDSNKDYASS
FSQTGHSPHI HQTPSPSFFL QDASKPLPLE QNTHSSLSES GAAFVMPTVK TEASSQTSSC
SGHVETRIES TSSLHLMQFQ ANFQAMAAEG EVTMETSQAA EGNEVLLKSG ELQACGSEHY
LQPETNGVIR SAGGVPLLPS NVVQGLYPVA QPSLGNSSNM ELSLDHFDIS FSNQFSDLIN
DFISVEGGSG TIYGHQLVSG DSAALSQSED GARAPFTQAE MCIPCCSPQQ GSLQLSSAEG
GPSTMAYMHV AEVVSAASAQ GALGMLQQSG RVFMVTDYSP EWSYPEGGVK VLITGPWQEA
SNNYSCLFDQ ISVPASLIQP GVLRCYCPAH DTGLVTLQVA FNNQIISNSV VFEYKARALP
TLPSSQHDWL SLDDNQFRMS ILERLEQMER RMAEMTGSQQ HKQASGGGGS GSGSGSGAGG
GQAQCASGAG TLGSCFESRV VVVCEKMMSR ACWAKSKHLI HSKTFRGMTL LHLAAAQGYA
TLIQTLIKWR TKHADSIDLE LEVDPLNVDH FSCTPLMWAC ALGHLEAAVV LYKWDRRAIS
IPDSLGRLPL GIARSRGHVK LAECLEHLQR DEQAQLGQAS RIHCAPSEEP TTDSWMAQWQ
REAMSPPEIP KGVTVIASTN PELRRPRSEP SNYYSTEGHK DYPAPKKHKL NPESFQARQE
KLLCTALSLE QPNIRKQSPR SKQPSPETIS PSEGVREYSR EAAPPTPETA ASQASASQPV
VKWSAKDLYI GVSTVQVTGN PKGTSVVKDA APSQVRPREP MSVLMLANRE VVNTEMGAYR
DRTEHEDCPQ PMDDIQVNMM TLAEHIIEAT PDRIKQENFV PMESSALERT DPATISSTMS
WLASYLADAD RLPSAAHIRS AYTEPLTPSS NASLSPAGSP VSEVAFEKPS LPSAADWSEF
LSASTSEKVE SELAQLTLSD HEQRELYEAA RLVQTAFRKY KGRPLREQQE VAAAVIQRCY
RKYKQLTWIA LKYALYKKMT QAAILIQSKF RSYYEQKRFQ QSRRAAVLIQ NFYRSYKKCG
RRRPARRTAV IVQQKLRSSL LTKKQDQAAR KIMRFLRRCR HSPLVDHRLY KRSERIEKGQ
GT
