CN093_HUMAN
ID CN093_HUMAN Reviewed; 538 AA.
AC Q9H972; B7WP03; D3DS38; D3DS39; Q86SE6; Q96CF7; Q9HA68;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Uncharacterized protein C14orf93;
DE Flags: Precursor;
GN Name=C14orf93;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cervix carcinoma, Neuroblastoma, and Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung adenocarcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224 AND SER-285, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [7]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-128 AND LYS-221, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC Q9H972; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-10329620, EBI-995714;
CC Q9H972-2; Q01658: DR1; NbExp=3; IntAct=EBI-11524174, EBI-750300;
CC Q9H972-2; Q00403: GTF2B; NbExp=3; IntAct=EBI-11524174, EBI-389564;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H972-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H972-2; Sequence=VSP_007850;
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DR EMBL; AK023026; BAB14363.1; -; mRNA.
DR EMBL; AK022216; BAB13988.1; -; mRNA.
DR EMBL; BX161383; CAD61874.1; -; mRNA.
DR EMBL; BX161417; CAD61892.1; -; mRNA.
DR EMBL; BX161474; CAD61930.1; -; mRNA.
DR EMBL; BX161507; CAD61946.1; -; mRNA.
DR EMBL; AL132780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471078; EAW66196.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66198.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66199.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66200.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66201.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66202.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66203.1; -; Genomic_DNA.
DR EMBL; BC014299; AAH14299.1; -; mRNA.
DR CCDS; CCDS61400.1; -. [Q9H972-2]
DR CCDS; CCDS9583.1; -. [Q9H972-1]
DR RefSeq; NP_001124178.1; NM_001130706.2. [Q9H972-1]
DR RefSeq; NP_001124180.1; NM_001130708.2. [Q9H972-1]
DR RefSeq; NP_001269897.1; NM_001282968.1.
DR RefSeq; NP_001269898.1; NM_001282969.1.
DR RefSeq; NP_001269899.1; NM_001282970.1. [Q9H972-2]
DR RefSeq; NP_068763.2; NM_021944.3. [Q9H972-1]
DR RefSeq; XP_005268028.1; XM_005267971.1. [Q9H972-1]
DR RefSeq; XP_005268029.1; XM_005267972.1. [Q9H972-1]
DR RefSeq; XP_006720294.1; XM_006720231.1.
DR RefSeq; XP_006720295.1; XM_006720232.2.
DR RefSeq; XP_011535361.1; XM_011537059.1. [Q9H972-1]
DR RefSeq; XP_011535362.1; XM_011537060.2. [Q9H972-1]
DR RefSeq; XP_011535364.1; XM_011537062.1. [Q9H972-1]
DR RefSeq; XP_016877058.1; XM_017021569.1.
DR RefSeq; XP_016877059.1; XM_017021570.1. [Q9H972-1]
DR RefSeq; XP_016877060.1; XM_017021571.1.
DR RefSeq; XP_016877061.1; XM_017021572.1. [Q9H972-1]
DR RefSeq; XP_016877062.1; XM_017021573.1. [Q9H972-1]
DR RefSeq; XP_016877063.1; XM_017021574.1. [Q9H972-1]
DR RefSeq; XP_016877064.1; XM_017021575.1.
DR RefSeq; XP_016877065.1; XM_017021576.1.
DR RefSeq; XP_016877066.1; XM_017021577.1.
DR AlphaFoldDB; Q9H972; -.
DR SMR; Q9H972; -.
DR BioGRID; 121959; 10.
DR IntAct; Q9H972; 5.
DR MINT; Q9H972; -.
DR STRING; 9606.ENSP00000299088; -.
DR iPTMnet; Q9H972; -.
DR PhosphoSitePlus; Q9H972; -.
DR BioMuta; C14orf93; -.
DR DMDM; 33301115; -.
DR EPD; Q9H972; -.
DR jPOST; Q9H972; -.
DR MassIVE; Q9H972; -.
DR MaxQB; Q9H972; -.
DR PaxDb; Q9H972; -.
DR PeptideAtlas; Q9H972; -.
DR PRIDE; Q9H972; -.
DR ProteomicsDB; 81287; -. [Q9H972-1]
DR ProteomicsDB; 81288; -. [Q9H972-2]
DR Antibodypedia; 120; 14 antibodies from 9 providers.
DR DNASU; 60686; -.
DR Ensembl; ENST00000299088.11; ENSP00000299088.6; ENSG00000100802.15. [Q9H972-1]
DR Ensembl; ENST00000341470.8; ENSP00000341353.4; ENSG00000100802.15. [Q9H972-2]
DR Ensembl; ENST00000397379.7; ENSP00000380535.3; ENSG00000100802.15. [Q9H972-1]
DR Ensembl; ENST00000397382.8; ENSP00000380538.4; ENSG00000100802.15. [Q9H972-1]
DR GeneID; 60686; -.
DR KEGG; hsa:60686; -.
DR MANE-Select; ENST00000299088.11; ENSP00000299088.6; NM_021944.4; NP_068763.2.
DR UCSC; uc001wia.6; human. [Q9H972-1]
DR CTD; 60686; -.
DR DisGeNET; 60686; -.
DR GeneCards; C14orf93; -.
DR HGNC; HGNC:20162; C14orf93.
DR HPA; ENSG00000100802; Low tissue specificity.
DR neXtProt; NX_Q9H972; -.
DR OpenTargets; ENSG00000100802; -.
DR PharmGKB; PA134982493; -.
DR VEuPathDB; HostDB:ENSG00000100802; -.
DR eggNOG; ENOG502QR1B; Eukaryota.
DR GeneTree; ENSGT00390000012708; -.
DR InParanoid; Q9H972; -.
DR OMA; FDQSHKT; -.
DR OrthoDB; 961389at2759; -.
DR PhylomeDB; Q9H972; -.
DR TreeFam; TF336941; -.
DR PathwayCommons; Q9H972; -.
DR SignaLink; Q9H972; -.
DR BioGRID-ORCS; 60686; 19 hits in 1071 CRISPR screens.
DR ChiTaRS; C14orf93; human.
DR GenomeRNAi; 60686; -.
DR Pharos; Q9H972; Tdark.
DR PRO; PR:Q9H972; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9H972; protein.
DR Bgee; ENSG00000100802; Expressed in granulocyte and 132 other tissues.
DR ExpressionAtlas; Q9H972; baseline and differential.
DR Genevisible; Q9H972; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0048856; P:anatomical structure development; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR InterPro; IPR028101; DUF4616.
DR PANTHER; PTHR14375; PTHR14375; 1.
DR Pfam; PF15394; DUF4616; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Secreted; Signal; Ubl conjugation.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..538
FT /note="Uncharacterized protein C14orf93"
FT /id="PRO_0000020950"
FT REGION 101..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 224
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 285
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 428
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8K2W9"
FT CROSSLNK 128
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 221
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 438..477
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_007850"
FT VARIANT 190
FT /note="A -> V (in dbSNP:rs3829409)"
FT /id="VAR_050875"
FT CONFLICT 394
FT /note="R -> L (in Ref. 5; AAH14299)"
FT /evidence="ECO:0000305"
FT CONFLICT 438
FT /note="G -> S (in Ref. 1; BAB13988)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 538 AA; 58697 MW; 0F4B47ABCC3F960C CRC64;
MSFSATILFS PPSGSEARCC CCACKSETNG GNTGSQGGNP PPSTPITVTG HGLAVQSSEQ
LLHVIYQRVD KAVGLAEAAL GLARANNELL KRLQEEVGDL RQGKVSIPDE DGESRAHSSP
PEEPGPLKES PGEAFKALSA VEEECDSVGS GVQVVIEELR QLGAASVGPG PLGFPATQRD
MRLPGCTLAA SEAAPLLNPL VDDYVASEGA VQRVLVPAYA KQLSPATQLA IQRATPETGP
ENGTKLPPPR PEDMLNAAAA LDSALEESGP GSTGELRHSL GLTVSPCRTR GSGQKNSRRK
RDLVLSKLVH NVHNHITNDK RFNGSESIKS SWNISVVKFL LEKLKQELVT SPHNYTDKEL
KGACVAYFLT KRREYRNSLN PFKGLKEKEE KKLRSRRYRL FANRSSIMRH FGPEDQRLWN
DVTEELMSDE EDSLNEPGVW VARPPRFRAQ RLTELCYHLD ANSKHGTKAN RVYGPPSDRL
PSAEAQLLPP ELYNPNFQEE EDEGGDENAP GSPSFDQPHK TCCPDLNSFI EIKVEKDE
