CN093_MOUSE
ID CN093_MOUSE Reviewed; 541 AA.
AC Q8K2W9;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Uncharacterized protein C14orf93 homolog;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-118; SER-286 AND SER-429, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; BC029624; AAH29624.1; -; mRNA.
DR CCDS; CCDS27094.1; -.
DR RefSeq; NP_083166.1; NM_028890.2.
DR RefSeq; XP_006519681.1; XM_006519618.3.
DR RefSeq; XP_006519682.1; XM_006519619.3.
DR RefSeq; XP_006519683.1; XM_006519620.3.
DR RefSeq; XP_011243512.1; XM_011245210.2.
DR AlphaFoldDB; Q8K2W9; -.
DR SMR; Q8K2W9; -.
DR STRING; 10090.ENSMUSP00000022786; -.
DR iPTMnet; Q8K2W9; -.
DR PhosphoSitePlus; Q8K2W9; -.
DR EPD; Q8K2W9; -.
DR jPOST; Q8K2W9; -.
DR MaxQB; Q8K2W9; -.
DR PaxDb; Q8K2W9; -.
DR PeptideAtlas; Q8K2W9; -.
DR PRIDE; Q8K2W9; -.
DR Antibodypedia; 120; 14 antibodies from 9 providers.
DR DNASU; 74359; -.
DR Ensembl; ENSMUST00000022786; ENSMUSP00000022786; ENSMUSG00000022179.
DR GeneID; 74359; -.
DR KEGG; mmu:74359; -.
DR UCSC; uc007twk.1; mouse.
DR MGI; MGI:1921609; 4931414P19Rik.
DR VEuPathDB; HostDB:ENSMUSG00000022179; -.
DR eggNOG; ENOG502QR1B; Eukaryota.
DR GeneTree; ENSGT00390000012708; -.
DR HOGENOM; CLU_037858_0_0_1; -.
DR InParanoid; Q8K2W9; -.
DR OMA; FDQSHKT; -.
DR OrthoDB; 961389at2759; -.
DR PhylomeDB; Q8K2W9; -.
DR TreeFam; TF336941; -.
DR BioGRID-ORCS; 74359; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8K2W9; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8K2W9; protein.
DR Bgee; ENSMUSG00000022179; Expressed in interventricular septum and 165 other tissues.
DR ExpressionAtlas; Q8K2W9; baseline and differential.
DR Genevisible; Q8K2W9; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048856; P:anatomical structure development; IMP:MGI.
DR GO; GO:0030154; P:cell differentiation; IMP:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI.
DR InterPro; IPR028101; DUF4616.
DR PANTHER; PTHR14375; PTHR14375; 1.
DR Pfam; PF15394; DUF4616; 1.
PE 1: Evidence at protein level;
KW Isopeptide bond; Phosphoprotein; Reference proteome; Secreted; Signal;
KW Ubl conjugation.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..541
FT /note="Uncharacterized protein C14orf93 homolog"
FT /id="PRO_0000020951"
FT REGION 28..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 118
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 226
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H972"
FT MOD_RES 286
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 429
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CROSSLNK 128
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9H972"
FT CROSSLNK 223
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9H972"
SQ SEQUENCE 541 AA; 58780 MW; D738EBF0BF6E304E CRC64;
MSFSATILFS PPSGSEARCC CCACKSETSQ GSTGSQGGNP PASTPITVTG HGLAVQSSEQ
LLHIIYQRVD KAVGLAEAAL GLARANNELL KQLQEEVGEL RQGKVCTADE DRESRARTPP
PEEPGVLKGS PGEASNSLPA MEEECDSVGS GVQVVIEELR QLGAASTVGQ GPLGFFAAPQ
RDARLPGCTL AAVEGAPLLN PMADDYVASE GSIQRVLVPA YAKQLSPATQ LAIQRASSET
GPESGTKLPA TRPEGVLGSA ALDSALDESG AGGAGELSRS LGFVGSPCRI RGTGQKNSRR
KRDLVLSKLV HNVHNHITND KRFNGSESIK SSWNISVVKF LLEKLKQELM VSPHNYTDKE
LKGACVAYFL TKRREYRNSL NPFKGLKEKE EKKLRSRRYR LFANRSSIMR HFGPEDQHLW
KDVTEELMSD EEDSLNEPGV WVARSPRFRA QRLTELCYHL DANSKHGTKA NRVYGPPSDR
LPSVEAQLLP PELYNPNFQE DEGGGNEKGP VSPSYDQPHK TSCPDLNSFI EIKVEKDEYT
L
