ID   CN10A_XENLA             Reviewed;         748 AA.
AC   Q6DE97;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=CCR4-NOT transcription complex subunit 10-A;
GN   Name=cnot10-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. Additional complex functions may be a
CC       consequence of its influence on mRNA expression. Is not required for
CC       association of CNOT7 to the CCR4-NOT complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CCR4-NOT complex. cnot10 and cnot11 form a
CC       subcomplex docked to the cnot1 scaffold (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CNOT10 family. {ECO:0000305}.
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DR   EMBL; BC077237; AAH77237.1; -; mRNA.
DR   RefSeq; NP_001086651.1; NM_001093182.1.
DR   AlphaFoldDB; Q6DE97; -.
DR   BioGRID; 103346; 1.
DR   IntAct; Q6DE97; 2.
DR   DNASU; 446486; -.
DR   GeneID; 446486; -.
DR   KEGG; xla:446486; -.
DR   CTD; 446486; -.
DR   Xenbase; XB-GENE-6256689; cnot10.L.
DR   OrthoDB; 249353at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 446486; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR039740; CNOT10.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12979; PTHR12979; 1.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-mediated gene silencing;
KW   Transcription; Transcription regulation; Translation regulation.
FT   CHAIN           1..748
FT                   /note="CCR4-NOT transcription complex subunit 10-A"
FT                   /id="PRO_0000314585"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          184..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          605..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        485..507
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   748 AA;  83421 MW;  E164E529A80E395E CRC64;
     MAADKAGEQG AEKHEDSANC SGISDHEKEL SRSALQAFTA GNYEACLQHL GELKEINKDD
     YKVILNSAVA EFYKSDQTTT DLLKQTLNQL RNEVHSAIDE IDSLDDVENS MLYYNQAVIL
     YYLRQHMEAI SIGEKLYQFI EPFKEKFAHA VCFLLVDLYL LTFQTEKALH LLVVLEKMIL
     QGHSNNKNGK NNETNSNANN REPFAQRGDG GVHVEAAKSK IHQYKVRAYI QMKSLKACKR
     EIKSVMNTSG NSAPSLFLKS NFEYLRGNYR KAVKLLNSSN IAEYPGFMKT GECVRCMFWN
     NLGCIHFAMG KHNLGLFYFK KALQENDNTC AQLPSSNTDP GKKFSSRPMC TLLTNKRYEL
     LYNCGIQLLH IGRPLAAFEY LIEAVQVYHS NPRLWLRLAE CCIAANKGTS EQETKGLPSK
     KGIVQSIVGQ GYHRKIVLAS QSVQNLLYND GESSAIPVAS MEFAAICLRN ALLLLPEDQF
     DAKQENGSKT SSQTGNTDSG GESSEVCSNK SHEGDKFIPA PPSSPLKRQE VENLRCSVLA
     CSAYVGLALG DNLMALNHAE KLLQQPRLSG SLKFLGHLYA AEALISLDRI SDAITHLNPE
     NVTDVSLGVS SNEQEQGSDK GENEPMESVG KQMPQCYPSS VTSARTMMLF NLGSAYCLRS
     EYDKARKCLH QAASMIHPKE IPPEAILLAV YLELQNGNTQ LALQIIKRNQ LLPSIRMMSD
     LRKKPLFQTM HQPMQPIQMP AFTAVQRK