CN119_HUMAN
ID CN119_HUMAN Reviewed; 140 AA.
AC Q9NWQ9; Q6IAA7;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Uncharacterized protein C14orf119;
GN Name=C14orf119; ORFNames=My028;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RA Mao Y.M., Xie Y., Ying K.;
RL Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ileal mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix, Lung, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=22361696; DOI=10.1016/j.jprot.2012.01.030;
RA Stadler C., Hjelmare M., Neumann B., Jonasson K., Pepperkok R., Uhlen M.,
RA Lundberg E.;
RT "Systematic validation of antibody binding and protein subcellular
RT localization using siRNA and confocal microscopy.";
RL J. Proteomics 75:2236-2251(2012).
CC -!- INTERACTION:
CC Q9NWQ9; P12814: ACTN1; NbExp=3; IntAct=EBI-725606, EBI-351710;
CC Q9NWQ9; O43707: ACTN4; NbExp=3; IntAct=EBI-725606, EBI-351526;
CC Q9NWQ9; A6NKF2: ARID3C; NbExp=3; IntAct=EBI-725606, EBI-12805486;
CC Q9NWQ9; Q03989: ARID5A; NbExp=3; IntAct=EBI-725606, EBI-948603;
CC Q9NWQ9; Q9H7T9: AUNIP; NbExp=3; IntAct=EBI-725606, EBI-10693257;
CC Q9NWQ9; Q8N7W2-2: BEND7; NbExp=3; IntAct=EBI-725606, EBI-10181188;
CC Q9NWQ9; Q9NQY0: BIN3; NbExp=3; IntAct=EBI-725606, EBI-2653038;
CC Q9NWQ9; Q9BXJ1-2: C1QTNF1; NbExp=3; IntAct=EBI-725606, EBI-11536642;
CC Q9NWQ9; P30281: CCND3; NbExp=3; IntAct=EBI-725606, EBI-375013;
CC Q9NWQ9; Q9UNH5: CDC14A; NbExp=3; IntAct=EBI-725606, EBI-7851002;
CC Q9NWQ9; Q9HD42: CHMP1A; NbExp=3; IntAct=EBI-725606, EBI-1057156;
CC Q9NWQ9; Q16740: CLPP; NbExp=3; IntAct=EBI-725606, EBI-1056029;
CC Q9NWQ9; P78358: CTAG1B; NbExp=3; IntAct=EBI-725606, EBI-1188472;
CC Q9NWQ9; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-725606, EBI-742054;
CC Q9NWQ9; Q9NUI1: DECR2; NbExp=3; IntAct=EBI-725606, EBI-3937367;
CC Q9NWQ9; P63167: DYNLL1; NbExp=3; IntAct=EBI-725606, EBI-349105;
CC Q9NWQ9; Q96FJ2: DYNLL2; NbExp=3; IntAct=EBI-725606, EBI-742371;
CC Q9NWQ9; Q96HZ4: HES6; NbExp=3; IntAct=EBI-725606, EBI-7469266;
CC Q9NWQ9; Q14774: HLX; NbExp=3; IntAct=EBI-725606, EBI-6678255;
CC Q9NWQ9; Q9P0W2: HMG20B; NbExp=3; IntAct=EBI-725606, EBI-713401;
CC Q9NWQ9; Q13352: ITGB3BP; NbExp=3; IntAct=EBI-725606, EBI-712105;
CC Q9NWQ9; Q7Z7F0-4: KHDC4; NbExp=3; IntAct=EBI-725606, EBI-9089060;
CC Q9NWQ9; P19013: KRT4; NbExp=3; IntAct=EBI-725606, EBI-2371606;
CC Q9NWQ9; Q8N1N4: KRT78; NbExp=3; IntAct=EBI-725606, EBI-1056564;
CC Q9NWQ9; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-725606, EBI-10241252;
CC Q9NWQ9; Q14847-2: LASP1; NbExp=3; IntAct=EBI-725606, EBI-9088686;
CC Q9NWQ9; O43679: LDB2; NbExp=3; IntAct=EBI-725606, EBI-2865580;
CC Q9NWQ9; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-725606, EBI-726510;
CC Q9NWQ9; P50221: MEOX1; NbExp=3; IntAct=EBI-725606, EBI-2864512;
CC Q9NWQ9; Q6PF18: MORN3; NbExp=3; IntAct=EBI-725606, EBI-9675802;
CC Q9NWQ9; P13349: MYF5; NbExp=3; IntAct=EBI-725606, EBI-17491620;
CC Q9NWQ9; Q9GZT8: NIF3L1; NbExp=3; IntAct=EBI-725606, EBI-740897;
CC Q9NWQ9; O00746: NME4; NbExp=3; IntAct=EBI-725606, EBI-744871;
CC Q9NWQ9; Q9NQ35: NRIP3; NbExp=3; IntAct=EBI-725606, EBI-10311735;
CC Q9NWQ9; Q7Z3B4: NUP54; NbExp=5; IntAct=EBI-725606, EBI-741048;
CC Q9NWQ9; P37198: NUP62; NbExp=5; IntAct=EBI-725606, EBI-347978;
CC Q9NWQ9; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-725606, EBI-10302990;
CC Q9NWQ9; Q9C0D0: PHACTR1; NbExp=3; IntAct=EBI-725606, EBI-7971325;
CC Q9NWQ9; Q96BK5: PINX1; NbExp=3; IntAct=EBI-725606, EBI-721782;
CC Q9NWQ9; Q8TBN0: RAB3IL1; NbExp=3; IntAct=EBI-725606, EBI-743796;
CC Q9NWQ9; Q04864-2: REL; NbExp=3; IntAct=EBI-725606, EBI-10829018;
CC Q9NWQ9; P61587: RND3; NbExp=3; IntAct=EBI-725606, EBI-1111534;
CC Q9NWQ9; P78317: RNF4; NbExp=3; IntAct=EBI-725606, EBI-2340927;
CC Q9NWQ9; P49247: RPIA; NbExp=3; IntAct=EBI-725606, EBI-744831;
CC Q9NWQ9; P49901: SMCP; NbExp=3; IntAct=EBI-725606, EBI-750494;
CC Q9NWQ9; Q9Y5X2: SNX8; NbExp=3; IntAct=EBI-725606, EBI-1752557;
CC Q9NWQ9; O60224: SSX4B; NbExp=3; IntAct=EBI-725606, EBI-745513;
CC Q9NWQ9; Q9H668: STN1; NbExp=4; IntAct=EBI-725606, EBI-746930;
CC Q9NWQ9; Q8IZU3: SYCP3; NbExp=3; IntAct=EBI-725606, EBI-7574149;
CC Q9NWQ9; Q5T0J7-2: TEX35; NbExp=3; IntAct=EBI-725606, EBI-12833746;
CC Q9NWQ9; Q08117-2: TLE5; NbExp=3; IntAct=EBI-725606, EBI-11741437;
CC Q9NWQ9; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-725606, EBI-11524408;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22361696}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF061731; AAG43142.1; -; mRNA.
DR EMBL; AK000678; BAA91320.1; -; mRNA.
DR EMBL; CR457248; CAG33529.1; -; mRNA.
DR EMBL; CH471078; EAW66185.1; -; Genomic_DNA.
DR EMBL; BC009645; AAH09645.1; -; mRNA.
DR EMBL; BC056255; AAH56255.1; -; mRNA.
DR EMBL; BC061637; AAH61637.1; -; mRNA.
DR CCDS; CCDS9588.1; -.
DR RefSeq; NP_060394.1; NM_017924.3.
DR RefSeq; XP_016876879.1; XM_017021390.1.
DR AlphaFoldDB; Q9NWQ9; -.
DR SMR; Q9NWQ9; -.
DR BioGRID; 120349; 59.
DR IntAct; Q9NWQ9; 54.
DR STRING; 9606.ENSP00000322238; -.
DR iPTMnet; Q9NWQ9; -.
DR PhosphoSitePlus; Q9NWQ9; -.
DR BioMuta; C14orf119; -.
DR EPD; Q9NWQ9; -.
DR jPOST; Q9NWQ9; -.
DR MassIVE; Q9NWQ9; -.
DR MaxQB; Q9NWQ9; -.
DR PaxDb; Q9NWQ9; -.
DR PeptideAtlas; Q9NWQ9; -.
DR PRIDE; Q9NWQ9; -.
DR ProteomicsDB; 82962; -.
DR TopDownProteomics; Q9NWQ9; -.
DR Antibodypedia; 177; 23 antibodies from 12 providers.
DR DNASU; 55017; -.
DR Ensembl; ENST00000319074.6; ENSP00000322238.4; ENSG00000179933.6.
DR Ensembl; ENST00000554203.1; ENSP00000450861.1; ENSG00000179933.6.
DR GeneID; 55017; -.
DR KEGG; hsa:55017; -.
DR MANE-Select; ENST00000319074.6; ENSP00000322238.4; NM_017924.4; NP_060394.1.
DR UCSC; uc001wiu.4; human.
DR CTD; 55017; -.
DR GeneCards; C14orf119; -.
DR HGNC; HGNC:20270; C14orf119.
DR HPA; ENSG00000179933; Low tissue specificity.
DR neXtProt; NX_Q9NWQ9; -.
DR OpenTargets; ENSG00000179933; -.
DR PharmGKB; PA134974692; -.
DR VEuPathDB; HostDB:ENSG00000179933; -.
DR eggNOG; ENOG502S13Y; Eukaryota.
DR GeneTree; ENSGT00390000007438; -.
DR HOGENOM; CLU_121983_1_0_1; -.
DR InParanoid; Q9NWQ9; -.
DR OMA; FREWSSN; -.
DR OrthoDB; 1591151at2759; -.
DR PhylomeDB; Q9NWQ9; -.
DR TreeFam; TF324452; -.
DR PathwayCommons; Q9NWQ9; -.
DR SignaLink; Q9NWQ9; -.
DR BioGRID-ORCS; 55017; 13 hits in 1052 CRISPR screens.
DR ChiTaRS; C14orf119; human.
DR GenomeRNAi; 55017; -.
DR Pharos; Q9NWQ9; Tdark.
DR PRO; PR:Q9NWQ9; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9NWQ9; protein.
DR Bgee; ENSG00000179933; Expressed in ileal mucosa and 185 other tissues.
DR Genevisible; Q9NWQ9; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR InterPro; IPR028019; DUF4508.
DR PANTHER; PTHR16260; PTHR16260; 1.
DR Pfam; PF14969; DUF4508; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..140
FT /note="Uncharacterized protein C14orf119"
FT /id="PRO_0000089929"
FT VARIANT 16
FT /note="L -> V (in dbSNP:rs35065609)"
FT /id="VAR_033744"
SQ SEQUENCE 140 AA; 16009 MW; 47D0756B0BDB1208 CRC64;
MPLESSSSMP LSFPSLLPSV PHNTNPSPPL MSYITSQEMK CILHWFANWS GPQRERFLED
LVAKAVPEKL QPLLDSLEQL SVSGADRPPS IFECQLHLWD QWFRGWAEQE RNEFVRQLEF
SEPDFVAKFY QAVAATAGKD
