CN177_HUMAN
ID CN177_HUMAN Reviewed; 125 AA.
AC Q52M58; Q8N7D2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Testis-specific protein LINC02914 {ECO:0000305};
DE AltName: Full=Long intergenic non-protein coding RNA 2914 {ECO:0000312|HGNC:HGNC:26375};
GN Name=LINC02914 {ECO:0000312|HGNC:HGNC:26375}; Synonyms=C14orf177;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TRP-3.
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=28891297; DOI=10.1021/acs.jproteome.7b00374;
RA Carapito C., Duek P., Macron C., Seffals M., Rondel K., Delalande F.,
RA Lindskog C., Freour T., Vandenbrouck Y., Lane L., Pineau C.;
RT "Validating Missing Proteins in Human Sperm Cells by Targeted Mass-
RT Spectrometry- and Antibody-based Methods.";
RL J. Proteome Res. 16:4340-4351(2017).
CC -!- FUNCTION: May play a role in the flagellum biology.
CC {ECO:0000303|PubMed:28891297}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28891297}. Nucleus
CC {ECO:0000269|PubMed:28891297}. Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:28891297}. Note=Detected in the cytoplasm of germ
CC cells in all stages of development up to the cytoplasmic lobes of
CC elongated spermatids, whereas it appeared stronger in the nucleus of
CC premeiotic and meiotic germ cells. Localizes in the headpiece and
CC midpiece of ejaculated sperm. {ECO:0000269|PubMed:28891297}.
CC -!- TISSUE SPECIFICITY: Expressed in testes and ejaculated spermatozoa (at
CC protein level). {ECO:0000269|PubMed:28891297}.
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DR EMBL; AK098639; BAC05361.1; -; mRNA.
DR EMBL; AL096821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC093661; AAH93661.1; -; mRNA.
DR RefSeq; NP_001333907.1; NM_001346978.1.
DR RefSeq; NP_001333908.1; NM_001346979.1.
DR RefSeq; NP_872366.2; NM_182560.2.
DR AlphaFoldDB; Q52M58; -.
DR STRING; 9606.ENSP00000321360; -.
DR iPTMnet; Q52M58; -.
DR PhosphoSitePlus; Q52M58; -.
DR BioMuta; C14orf177; -.
DR PaxDb; Q52M58; -.
DR PRIDE; Q52M58; -.
DR UCSC; uc001yfz.3; human.
DR GeneCards; LINC02914; -.
DR HGNC; HGNC:26375; LINC02914.
DR neXtProt; NX_Q52M58; -.
DR eggNOG; ENOG502TFG8; Eukaryota.
DR HOGENOM; CLU_1991869_0_0_1; -.
DR InParanoid; Q52M58; -.
DR OrthoDB; 1371654at2759; -.
DR PhylomeDB; Q52M58; -.
DR TreeFam; TF340679; -.
DR PathwayCommons; Q52M58; -.
DR BioGRID-ORCS; 283598; 11 hits in 1028 CRISPR screens.
DR GenomeRNAi; 283598; -.
DR Pharos; Q52M58; Tdark.
DR PRO; PR:Q52M58; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q52M58; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR040821; LINC02914-like.
DR Pfam; PF17698; DUF5544; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cytoplasm; Flagellum; Nucleus; Reference proteome.
FT CHAIN 1..125
FT /note="Testis-specific protein LINC02914"
FT /id="PRO_0000274267"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 3
FT /note="R -> W (in dbSNP:rs17097718)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030224"
FT VARIANT 33
FT /note="V -> A (in dbSNP:rs4905757)"
FT /id="VAR_030225"
SQ SEQUENCE 125 AA; 13861 MW; 6B2126D00D60976B CRC64;
MHRKEPGARL EATRGAARPH KQGTKPMITR PSVSQLGEGK CPSSQHLQSL RHNKQHALTL
TKARCCGECS TCFCTEEKSE CQRHEETSPG SCNHQIMSAS TISAFCATPR FKQLFKGTVE
QMSQM
