CN178_HUMAN
ID CN178_HUMAN Reviewed; 122 AA.
AC Q8N769; Q2HIX2; Q3KNR7;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Uncharacterized protein C14orf178;
GN Name=C14orf178;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANT
RP TYR-26.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N769-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N769-2; Sequence=VSP_022698;
CC Name=3;
CC IsoId=Q8N769-3; Sequence=VSP_022699, VSP_022700;
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DR EMBL; AK098842; BAC05432.1; -; mRNA.
DR EMBL; AC008372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC107147; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC113929; AAI13930.1; -; mRNA.
DR EMBL; BC113986; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001167449.1; NM_001173978.1.
DR RefSeq; NP_777603.1; NM_174943.3.
DR AlphaFoldDB; Q8N769; -.
DR BioGRID; 129609; 19.
DR IntAct; Q8N769; 1.
DR STRING; 9606.ENSP00000348145; -.
DR BioMuta; C14orf178; -.
DR PaxDb; Q8N769; -.
DR PeptideAtlas; Q8N769; -.
DR PRIDE; Q8N769; -.
DR UCSC; uc021rwv.2; human. [Q8N769-1]
DR GeneCards; C14orf178; -.
DR HGNC; HGNC:26385; C14orf178.
DR neXtProt; NX_Q8N769; -.
DR PharmGKB; PA145149665; -.
DR eggNOG; ENOG502TK8A; Eukaryota.
DR HOGENOM; CLU_165588_0_0_1; -.
DR InParanoid; Q8N769; -.
DR OrthoDB; 1471346at2759; -.
DR PhylomeDB; Q8N769; -.
DR TreeFam; TF351556; -.
DR PathwayCommons; Q8N769; -.
DR SignaLink; Q8N769; -.
DR BioGRID-ORCS; 283579; 30 hits in 716 CRISPR screens.
DR ChiTaRS; C14orf178; human.
DR GenomeRNAi; 283579; -.
DR Pharos; Q8N769; Tdark.
DR PRO; PR:Q8N769; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8N769; protein.
DR Genevisible; Q8N769; HS.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..122
FT /note="Uncharacterized protein C14orf178"
FT /id="PRO_0000274284"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 25..122
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022698"
FT VAR_SEQ 30..37
FT /note="EMGSHYFA -> GTESVFWL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022699"
FT VAR_SEQ 38..122
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022700"
FT VARIANT 26
FT /note="H -> Y (in dbSNP:rs8015313)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030248"
SQ SEQUENCE 122 AA; 13377 MW; 5948DAEEC2A1DB9F CRC64;
MGREMKKTGT PRPFRIEDPN QQPTWHDQPE MGSHYFAQAG LELLGSSNPP ASASQSAGIT
GVSHCARPGE HDLNHTVFQV KDSTFLRHLE SDRPEFKSCL PPHFTEPSVS LSTSEGCEDA
MG
