CNBD1_HUMAN
ID CNBD1_HUMAN Reviewed; 436 AA.
AC Q8NA66;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein 1;
GN Name=CNBD1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK093121; BAC04062.1; -; mRNA.
DR EMBL; BC117326; AAI17327.1; -; mRNA.
DR EMBL; BC117328; AAI17329.1; -; mRNA.
DR CCDS; CCDS55259.1; -.
DR RefSeq; NP_775809.1; NM_173538.2.
DR AlphaFoldDB; Q8NA66; -.
DR SMR; Q8NA66; -.
DR BioGRID; 127974; 1.
DR IntAct; Q8NA66; 1.
DR STRING; 9606.ENSP00000430073; -.
DR CarbonylDB; Q8NA66; -.
DR iPTMnet; Q8NA66; -.
DR PhosphoSitePlus; Q8NA66; -.
DR BioMuta; CNBD1; -.
DR DMDM; 74729846; -.
DR MassIVE; Q8NA66; -.
DR PaxDb; Q8NA66; -.
DR PeptideAtlas; Q8NA66; -.
DR PRIDE; Q8NA66; -.
DR Antibodypedia; 25531; 23 antibodies from 7 providers.
DR DNASU; 168975; -.
DR Ensembl; ENST00000518476.6; ENSP00000430073.1; ENSG00000176571.12.
DR GeneID; 168975; -.
DR KEGG; hsa:168975; -.
DR MANE-Select; ENST00000518476.6; ENSP00000430073.1; NM_173538.3; NP_775809.1.
DR UCSC; uc003ydy.3; human.
DR CTD; 168975; -.
DR GeneCards; CNBD1; -.
DR HGNC; HGNC:26663; CNBD1.
DR HPA; ENSG00000176571; Tissue enriched (testis).
DR neXtProt; NX_Q8NA66; -.
DR OpenTargets; ENSG00000176571; -.
DR PharmGKB; PA142672090; -.
DR VEuPathDB; HostDB:ENSG00000176571; -.
DR eggNOG; ENOG502QVKZ; Eukaryota.
DR GeneTree; ENSGT00390000001688; -.
DR HOGENOM; CLU_039975_0_0_1; -.
DR InParanoid; Q8NA66; -.
DR OMA; FVKLQSN; -.
DR OrthoDB; 955236at2759; -.
DR PhylomeDB; Q8NA66; -.
DR TreeFam; TF337630; -.
DR PathwayCommons; Q8NA66; -.
DR SignaLink; Q8NA66; -.
DR BioGRID-ORCS; 168975; 12 hits in 1056 CRISPR screens.
DR ChiTaRS; CNBD1; human.
DR GenomeRNAi; 168975; -.
DR Pharos; Q8NA66; Tdark.
DR PRO; PR:Q8NA66; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8NA66; protein.
DR Bgee; ENSG00000176571; Expressed in oocyte and 85 other tissues.
DR ExpressionAtlas; Q8NA66; baseline and differential.
DR Genevisible; Q8NA66; HS.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; -; 2.
DR InterPro; IPR043533; CNBD1/2.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR23011; PTHR23011; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR SUPFAM; SSF51206; SSF51206; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..436
FT /note="Cyclic nucleotide-binding domain-containing protein
FT 1"
FT /id="PRO_0000291777"
FT REGION 89..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 322..436
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT VARIANT 64
FT /note="D -> N (in dbSNP:rs10504829)"
FT /id="VAR_032859"
FT VARIANT 69
FT /note="Q -> K (in dbSNP:rs16894901)"
FT /id="VAR_032860"
FT VARIANT 257
FT /note="M -> V (in dbSNP:rs60556175)"
FT /id="VAR_061108"
SQ SEQUENCE 436 AA; 50224 MW; 16ABA68561881EA1 CRC64;
MPMSSLPAAI LSHMTAINNV PPPPLHSIPN LKKSKHINYG QLNALCHIRG QHSRSMSNIL
SAHDTFMKQY PKVFLHQKPR LPKLFKQEEQ RELNEGKEES QHQQPDDSNN IAVHVQRAHG
GHILYRPKRA TEKFEEFLAI LKKLPIHRTP YEHKTVWKFL KTIPDLTFQL NDKHLKTLSK
TVFSETWLKG STVVANDGFY VILKGLARPQ TNVYKNLIEG SDSPDSFISQ SFHSFIWSEE
FKNSTLAEMY LPSYDSMLSK WSTFGTLEVM PQNESETQMF SVVTEDDCEI LKIPAKGYAK
IKEEKIKLEN MQKLKLIRMC PYYEEWPTLS IYELIALLKW KKFPPGHVIV ESGNIISFVG
YINSGCCNIY RSIIGFVKLR SNKVKRSQKL VYMGKLKEKE SFGEISVLLQ VPFTCTIITK
KEVEMAIIED KDLFVA
