ID   CNBD2_MACFA             Reviewed;         585 AA.
AC   Q95JR6; Q95JT5;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Cyclic nucleotide-binding domain-containing protein 2;
GN   Name=CNBD2; ORFNames=QtsA-11192, QtsA-13521;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: Essential for male fertility. Plays an important role in
CC       spermatogenesis and regulates sperm motility by controlling the
CC       development of the flagellar bending of sperm.
CC       {ECO:0000250|UniProtKB:Q9D5U8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9D5U8}.
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DR   EMBL; AB070094; BAB63039.1; -; mRNA.
DR   EMBL; AB070113; BAB63058.1; -; mRNA.
DR   AlphaFoldDB; Q95JR6; -.
DR   SMR; Q95JR6; -.
DR   STRING; 9541.XP_005568938.1; -.
DR   PRIDE; Q95JR6; -.
DR   eggNOG; KOG1113; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 2.
DR   InterPro; IPR043533; CNBD1/2.
DR   InterPro; IPR038897; CNBD2.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR23011; PTHR23011; 1.
DR   PANTHER; PTHR23011:SF35; PTHR23011:SF35; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 2.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   2: Evidence at transcript level;
KW   cAMP; cAMP-binding; Cytoplasm; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..585
FT                   /note="Cyclic nucleotide-binding domain-containing protein
FT                   2"
FT                   /id="PRO_0000079472"
FT   BINDING         116..239
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
FT   CONFLICT        193
FT                   /note="Q -> L (in Ref. 1; BAB63039)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   585 AA;  68620 MW;  5840673091737AE4 CRC64;
     MRRYMVTYAW QLLKKELGLY QFATDIIVMI RVCKMFRQGL RGFREYQIIE SAHWKHPIFS
     FWDKKIQSRV TFDTMDFIAE EGHFPPKAIQ IMQKKPSWRT EDEIQTVCNI LQVLDSYRNY
     AEPLQLLLAK VMRFERFGRR RVIIKKGQKG NSFYFIYLGT VAITNDEDGS SAFLDPHPKL
     LQKGSCFGET DIQHASLRRS TIVCMEETEF LVVDREDFFA NKLDQEVQKD AQYRFEFFRK
     MDLFASWSDE KLWQLVNMSK IERFSYGQLI SKDFGESSFI MFISKGSCEV LRLLDLGASP
     SYHRWVWQHL ELIDDRPLKT HLREYSPMER FKEFQIKSYP LQDFSSLKLL HLKKAWGLQG
     TSFSRKIGTS GDTLPKMLGP KIQSRPVQSI KCAMINTKFG ELPKEAAVGA YMKVHTVEQG
     EILGLHQAFL PEGECDTRPL ILMSLGNELI RIRKEIFYEL IDNDDEMIKK LLKLNIAFPS
     DEDMCQKFLQ ENSWNIFRKD LLRLLVEPRQ SPPFPPIRPK KKEIYNPKSV VLDLCSINKT
     TKPRYPIFMA PQKYLPPLRI VQAIKAPRYK IQELLPQYKS AGVLI