ID   CNBP1_BOVIN             Reviewed;          81 AA.
AC   Q5E9N2;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Beta-catenin-interacting protein 1;
GN   Name=CTNNBIP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Prevents the interaction between CTNNB1 and TCF family
CC       members, and acts as negative regulator of the Wnt signaling pathway.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds CTNNB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CTNNBIP1 family. {ECO:0000305}.
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DR   EMBL; BT020888; AAX08905.1; -; mRNA.
DR   RefSeq; NP_001032219.1; NM_001037142.1.
DR   RefSeq; XP_005217039.1; XM_005216982.2.
DR   RefSeq; XP_010811577.1; XM_010813275.2.
DR   AlphaFoldDB; Q5E9N2; -.
DR   SMR; Q5E9N2; -.
DR   STRING; 9913.ENSBTAP00000007790; -.
DR   PaxDb; Q5E9N2; -.
DR   Ensembl; ENSBTAT00000007790; ENSBTAP00000007790; ENSBTAG00000005933.
DR   Ensembl; ENSBTAT00000077468; ENSBTAP00000068342; ENSBTAG00000005933.
DR   GeneID; 614630; -.
DR   KEGG; bta:614630; -.
DR   CTD; 56998; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005933; -.
DR   VGNC; VGNC:27803; CTNNBIP1.
DR   eggNOG; ENOG502S3XR; Eukaryota.
DR   GeneTree; ENSGT00940000161133; -.
DR   HOGENOM; CLU_145119_1_0_1; -.
DR   InParanoid; Q5E9N2; -.
DR   OMA; SHEEMYI; -.
DR   OrthoDB; 1457177at2759; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000005933; Expressed in surface of tongue and 103 other tissues.
DR   ExpressionAtlas; Q5E9N2; baseline and differential.
DR   GO; GO:0030877; C:beta-catenin destruction complex; IBA:GO_Central.
DR   GO; GO:1990711; C:beta-catenin-ICAT complex; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0070016; F:armadillo repeat domain binding; IEA:Ensembl.
DR   GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR   GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0043392; P:negative regulation of DNA binding; IEA:Ensembl.
DR   GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR   GO; GO:0072201; P:negative regulation of mesenchymal cell proliferation; IEA:Ensembl.
DR   GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
DR   GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:Ensembl.
DR   GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0060633; P:negative regulation of transcription initiation from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0045657; P:positive regulation of monocyte differentiation; IEA:Ensembl.
DR   GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0002528; P:regulation of vascular permeability involved in acute inflammatory response; IEA:Ensembl.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.490; -; 1.
DR   InterPro; IPR042999; CTNNBIP1.
DR   InterPro; IPR009428; ICAT_dom.
DR   InterPro; IPR036911; ICAT_sf.
DR   PANTHER; PTHR47142; PTHR47142; 1.
DR   Pfam; PF06384; ICAT; 1.
DR   SUPFAM; SSF81730; SSF81730; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome;
KW   Wnt signaling pathway.
FT   CHAIN           1..81
FT                   /note="Beta-catenin-interacting protein 1"
FT                   /id="PRO_0000263697"
FT   MOD_RES         59
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJN6"
SQ   SEQUENCE   81 AA;  9228 MW;  C586DE90B517636A CRC64;
     MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTANEEEF LRTYAGVVNS QLSQLPQHSI
     DQGAEDVVMA FSRSETEDRR Q