CNBP_CHICK
ID CNBP_CHICK Reviewed; 172 AA.
AC O42395;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=CCHC-type zinc finger nucleic acid binding protein {ECO:0000305};
DE AltName: Full=Cellular nucleic acid-binding protein {ECO:0000305};
DE Short=CNBP {ECO:0000305};
DE AltName: Full=Zinc finger protein 9;
GN Name=CNBP; Synonyms=ZNF9;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9467877; DOI=10.1016/s0305-0491(97)00276-9;
RA van Heumen W.R.A., Claxton C., Pickles J.O.;
RT "Sequence and tissue distribution of chicken cellular nucleic acid binding
RT protein cDNA.";
RL Comp. Biochem. Physiol. 118B:659-665(1997).
CC -!- FUNCTION: Single-stranded DNA-binding protein that preferentially binds
CC to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and
CC thereby mediates transcriptional repression (By similarity). Has a role
CC as transactivator of the Myc promoter (By similarity). Binds single-
CC stranded RNA in a sequence-specific manner (By similarity). Binds G-
CC rich elements in target mRNA coding sequences (By similarity). Prevents
CC G-quadruplex structure formation in vitro, suggesting a role in
CC supporting translation by resolving stable structures on mRNAs (By
CC similarity). {ECO:0000250|UniProtKB:P53996,
CC ECO:0000250|UniProtKB:P62633, ECO:0000250|UniProtKB:P62634}.
CC -!- SUBUNIT: Associates with the 40S ribosomal subunit, the 80S ribosome
CC and with polysomes. {ECO:0000250|UniProtKB:P62633}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53996}. Cytoplasm
CC {ECO:0000250|UniProtKB:P62633}. Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:P53996}.
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DR EMBL; AF004942; AAB62243.1; -; mRNA.
DR RefSeq; NP_990238.1; NM_204907.1.
DR AlphaFoldDB; O42395; -.
DR STRING; 9031.ENSGALP00000035496; -.
DR PaxDb; O42395; -.
DR PRIDE; O42395; -.
DR GeneID; 395731; -.
DR KEGG; gga:395731; -.
DR CTD; 7555; -.
DR VEuPathDB; HostDB:geneid_395731; -.
DR eggNOG; KOG4400; Eukaryota.
DR InParanoid; O42395; -.
DR PhylomeDB; O42395; -.
DR PRO; PR:O42395; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0045182; F:translation regulator activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:2000767; P:positive regulation of cytoplasmic translation; IBA:GO_Central.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR Pfam; PF00098; zf-CCHC; 7.
DR SMART; SM00343; ZnF_C2HC; 7.
DR SUPFAM; SSF57756; SSF57756; 4.
DR PROSITE; PS50158; ZF_CCHC; 7.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-binding; Endoplasmic reticulum; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..172
FT /note="CCHC-type zinc finger nucleic acid binding protein"
FT /id="PRO_0000089964"
FT ZN_FING 4..21
FT /note="CCHC-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 46..63
FT /note="CCHC-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 67..84
FT /note="CCHC-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 91..108
FT /note="CCHC-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 112..129
FT /note="CCHC-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 130..147
FT /note="CCHC-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT ZN_FING 151..168
FT /note="CCHC-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
SQ SEQUENCE 172 AA; 19043 MW; 123F4E248A980390 CRC64;
MSSNECFKCG RTGHWARECP TGIGRGRGMR SRGRAGFQFM SSSLPDICYR CGESGHLAKD
CDLQEDKACY NCGRGGHIAK DCKEPKRERE QCCYNCGKPG HLARDCDHAD EQKCYSCGEF
GHIQKDCTKV KCYRCGETGH VAINCSKTSE VNCYRCGESG HLARECTIEA TA
