CNCG_BOVIN
ID CNCG_BOVIN Reviewed; 83 AA.
AC P22571;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma;
DE Short=GMP-PDE gamma;
DE EC=3.1.4.35;
GN Name=PDE6H;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2162841; DOI=10.1016/s0021-9258(19)38585-0;
RA Hamilton S.E., Hurley J.B.;
RT "A phosphodiesterase inhibitor specific to a subset of bovine retinal
RT cones.";
RL J. Biol. Chem. 265:11259-11264(1990).
CC -!- FUNCTION: Participates in processes of transmission and amplification
CC of the visual signal. cGMP-PDEs are the effector molecules in G-
CC protein-mediated phototransduction in vertebrate rods and cones.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746,
CC ChEBI:CHEBI:58115; EC=3.1.4.35;
CC -!- SUBUNIT: Tetramer composed of two catalytic chains (alpha and beta),
CC and two inhibitory chains (gamma).
CC -!- DOMAIN: The C-terminal region is important in conferring inhibition.
CC -!- SIMILARITY: Belongs to the rod/cone cGMP-PDE gamma subunit family.
CC {ECO:0000305}.
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DR EMBL; J05578; AAA30689.1; -; mRNA.
DR RefSeq; NP_776847.1; NM_174422.2.
DR AlphaFoldDB; P22571; -.
DR SMR; P22571; -.
DR STRING; 9913.ENSBTAP00000018123; -.
DR BindingDB; P22571; -.
DR ChEMBL; CHEMBL2096979; -.
DR DrugCentral; P22571; -.
DR PaxDb; P22571; -.
DR Ensembl; ENSBTAT00000018123; ENSBTAP00000018123; ENSBTAG00000013635.
DR GeneID; 281978; -.
DR KEGG; bta:281978; -.
DR CTD; 5149; -.
DR VEuPathDB; HostDB:ENSBTAG00000013635; -.
DR VGNC; VGNC:32684; PDE6H.
DR eggNOG; ENOG502S4P1; Eukaryota.
DR GeneTree; ENSGT00390000013260; -.
DR HOGENOM; CLU_170469_0_0_1; -.
DR InParanoid; P22571; -.
DR OMA; QFKRNFG; -.
DR OrthoDB; 1574918at2759; -.
DR TreeFam; TF333297; -.
DR PRO; PR:P22571; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000013635; Expressed in retina and 17 other tissues.
DR GO; GO:0042622; C:photoreceptor outer segment membrane; IBA:GO_Central.
DR GO; GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:UniProtKB-EC.
DR GO; GO:0030553; F:cGMP binding; IEA:InterPro.
DR GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1120.10; -; 1.
DR InterPro; IPR006952; PDE6_gamma.
DR InterPro; IPR037030; PDE6_gamma_sf.
DR PANTHER; PTHR12122; PTHR12122; 1.
DR Pfam; PF04868; PDE6_gamma; 1.
DR PIRSF; PIRSF000969; 35-cGMP_Pdiase_g; 1.
PE 3: Inferred from homology;
KW cGMP; Hydrolase; Reference proteome; Sensory transduction; Vision.
FT CHAIN 1..83
FT /note="Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic
FT phosphodiesterase subunit gamma"
FT /id="PRO_0000166119"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..39
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 83 AA; 9102 MW; 755D0639015327DA CRC64;
MSDNTVLAPP TSNQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI
TVICPWEAFS HLELHELAQF GII
