ID   CNCG_ICTTR              Reviewed;          83 AA.
AC   O55175;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma;
DE            Short=GMP-PDE gamma;
DE            EC=3.1.4.35;
GN   Name=PDE6H;
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=9555081; DOI=10.1016/s0169-328x(97)00375-6;
RA   von Schantz M., Szel A., van Veen T., Farber D.B.;
RT   "Cloning of a cyclic GMP phosphodiesterase gamma subunit from the ground
RT   squirrel retina.";
RL   Brain Res. Mol. Brain Res. 54:327-333(1998).
CC   -!- FUNCTION: Participates in processes of transmission and amplification
CC       of the visual signal. cGMP-PDEs are the effector molecules in G-
CC       protein-mediated phototransduction in vertebrate rods and cones.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746,
CC         ChEBI:CHEBI:58115; EC=3.1.4.35;
CC   -!- SUBUNIT: Tetramer composed of two catalytic chains (alpha and beta),
CC       and two inhibitory chains (gamma).
CC   -!- DOMAIN: The C-terminal region is important in conferring inhibition.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the rod/cone cGMP-PDE gamma subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AJ001390; CAA04720.1; -; mRNA.
DR   RefSeq; XP_005331938.1; XM_005331881.1.
DR   AlphaFoldDB; O55175; -.
DR   SMR; O55175; -.
DR   STRING; 43179.ENSSTOP00000008149; -.
DR   Ensembl; ENSSTOT00000009089; ENSSTOP00000008149; ENSSTOG00000009094.
DR   GeneID; 101975706; -.
DR   CTD; 5149; -.
DR   eggNOG; ENOG502S4P1; Eukaryota.
DR   GeneTree; ENSGT00390000013260; -.
DR   HOGENOM; CLU_170469_0_0_1; -.
DR   InParanoid; O55175; -.
DR   OMA; ARMENEP; -.
DR   TreeFam; TF333297; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030553; F:cGMP binding; IEA:InterPro.
DR   GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.1120.10; -; 1.
DR   InterPro; IPR006952; PDE6_gamma.
DR   InterPro; IPR037030; PDE6_gamma_sf.
DR   PANTHER; PTHR12122; PTHR12122; 1.
DR   Pfam; PF04868; PDE6_gamma; 1.
DR   PIRSF; PIRSF000969; 35-cGMP_Pdiase_g; 1.
PE   3: Inferred from homology;
KW   cGMP; Hydrolase; Reference proteome; Sensory transduction; Vision.
FT   CHAIN           1..83
FT                   /note="Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic
FT                   phosphodiesterase subunit gamma"
FT                   /id="PRO_0000166123"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..39
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   83 AA;  9015 MW;  5AA76840BFE972DC CRC64;
     MSDNTTLAPP AASQAPATPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI
     TVICPWEAFS HLELHELAQF GII