ID   CNCG_RAT                Reviewed;          83 AA.
AC   P61250; Q9D1Y6; Q9EP63;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma;
DE            Short=GMP-PDE gamma;
DE            EC=3.1.4.35;
GN   Name=Pde6h;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Tate R.J., Pyne N.J.;
RT   "Molecular cloning and characterization of a cone-like phosphodiesterase 6
RT   gamma in rat testis.";
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in processes of transmission and amplification
CC       of the visual signal. cGMP-PDEs are the effector molecules in G-
CC       protein-mediated phototransduction in vertebrate rods and cones (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746,
CC         ChEBI:CHEBI:58115; EC=3.1.4.35;
CC   -!- SUBUNIT: Tetramer composed of two catalytic chains (alpha and beta),
CC       and two inhibitory chains (gamma).
CC   -!- DOMAIN: The C-terminal region is important in conferring inhibition.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the rod/cone cGMP-PDE gamma subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AF169390; AAG43400.1; -; mRNA.
DR   RefSeq; NP_446140.1; NM_053688.2.
DR   RefSeq; XP_006237620.1; XM_006237558.3.
DR   RefSeq; XP_017447868.1; XM_017592379.1.
DR   RefSeq; XP_017447869.1; XM_017592380.1.
DR   AlphaFoldDB; P61250; -.
DR   SMR; P61250; -.
DR   STRING; 10116.ENSRNOP00000007905; -.
DR   PhosphoSitePlus; P61250; -.
DR   PaxDb; P61250; -.
DR   Ensembl; ENSRNOT00000007905; ENSRNOP00000007905; ENSRNOG00000005947.
DR   GeneID; 114248; -.
DR   KEGG; rno:114248; -.
DR   UCSC; RGD:70933; rat.
DR   CTD; 5149; -.
DR   RGD; 70933; Pde6h.
DR   eggNOG; ENOG502S4P1; Eukaryota.
DR   GeneTree; ENSGT00390000013260; -.
DR   HOGENOM; CLU_170469_0_0_1; -.
DR   InParanoid; P61250; -.
DR   OMA; QFKRNFG; -.
DR   OrthoDB; 1574918at2759; -.
DR   PhylomeDB; P61250; -.
DR   TreeFam; TF333297; -.
DR   PRO; PR:P61250; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000005947; Expressed in spleen and 13 other tissues.
DR   Genevisible; P61250; RN.
DR   GO; GO:0042622; C:photoreceptor outer segment membrane; IBA:GO_Central.
DR   GO; GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030553; F:cGMP binding; IEA:InterPro.
DR   GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; ISO:RGD.
DR   GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; ISO:RGD.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.1120.10; -; 1.
DR   InterPro; IPR006952; PDE6_gamma.
DR   InterPro; IPR037030; PDE6_gamma_sf.
DR   PANTHER; PTHR12122; PTHR12122; 1.
DR   Pfam; PF04868; PDE6_gamma; 1.
DR   PIRSF; PIRSF000969; 35-cGMP_Pdiase_g; 1.
PE   3: Inferred from homology;
KW   cGMP; Hydrolase; Reference proteome; Sensory transduction; Vision.
FT   CHAIN           1..83
FT                   /note="Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic
FT                   phosphodiesterase subunit gamma"
FT                   /id="PRO_0000166122"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..39
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   83 AA;  9044 MW;  D84EC90839A834FF CRC64;
     MSDSPCLSPP APSQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI
     TVICPWEAFS HLELHELAQF GII