CNC_DROME
ID CNC_DROME Reviewed; 1383 AA.
AC P20482; A4V398; C7LAC2; O96506; Q1WWD8; Q9TZS3; Q9VCP6; Q9VCP8; Q9VCP9;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 3.
DT 03-AUG-2022, entry version 196.
DE RecName: Full=Segmentation protein cap'n'collar;
GN Name=cnc; ORFNames=CG43286;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=1911393; DOI=10.1016/0925-4773(91)90086-l;
RA Mohler J., Vani K., Leung S., Epstein A.;
RT "Segmentally restricted, cephalic expression of a leucine zipper gene
RT during Drosophila embryogenesis.";
RL Mech. Dev. 34:3-9(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C), FUNCTION, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9778513; DOI=10.1242/dev.125.22.4553;
RA McGinnis N., Ragnhildstveit E., Veraksa A., McGinnis W.;
RT "A cap 'n' collar protein isoform contains a selective Hox repressor
RT function.";
RL Development 125:4553-4564(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-343 (ISOFORM C).
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Booth B., Chavez C., Frise E., George R.A.,
RA Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in posterior cephalic patterning. Probable
CC subunit of a heterodimeric regulatory protein involved in the control
CC of head morphogenesis. Isoform B may have a repressive effect on Dfd
CC response elements, thereby modifying the activity and specificity of
CC the Hox system and moving the body anterior/posterior axis.
CC {ECO:0000269|PubMed:1911393, ECO:0000269|PubMed:9778513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978,
CC ECO:0000269|PubMed:9778513}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=C;
CC IsoId=P20482-1; Sequence=Displayed;
CC Name=B;
CC IsoId=P20482-2; Sequence=VSP_009457;
CC Name=A; Synonyms=D, E, F, G;
CC IsoId=P20482-3; Sequence=VSP_009458;
CC -!- TISSUE SPECIFICITY: Embryonic expression of isoform B is localized to
CC the mandibular segment and the hypopharyngeal and labral primordia
CC first detectable in late blastoderm stages. Embryonic expression of
CC isoforms B and C is ubiquitous. {ECO:0000269|PubMed:1911393,
CC ECO:0000269|PubMed:9778513}.
CC -!- DEVELOPMENTAL STAGE: Isoforms A and C are maternally and zygotically
CC expressed in embryos. Isoform A reduced between 2-12 hours embryos and
CC then increases. Isoform B is expressed in later embryonic stages.
CC Isoform C has the lowest expression level of the isoforms.
CC {ECO:0000269|PubMed:9778513}.
CC -!- SIMILARITY: Belongs to the bZIP family. CNC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC72898.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=ABE01198.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=ACV32772.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; M37495; AAB59246.1; -; mRNA.
DR EMBL; AF070062; AAC72896.1; -; mRNA.
DR EMBL; AF070063; AAC72897.1; -; mRNA.
DR EMBL; AF070064; AAC72898.1; ALT_FRAME; mRNA.
DR EMBL; AE014297; AAF56108.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF56109.2; -; Genomic_DNA.
DR EMBL; AE014297; AAF56111.2; -; Genomic_DNA.
DR EMBL; AE014297; AAN13930.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13931.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13932.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13933.1; -; Genomic_DNA.
DR EMBL; AY061154; AAL28702.1; -; mRNA.
DR EMBL; BT024968; ABE01198.1; ALT_SEQ; mRNA.
DR EMBL; BT099672; ACV32772.1; ALT_INIT; mRNA.
DR PIR; A33111; A33111.
DR PIR; T13936; T13936.
DR RefSeq; NP_001247256.1; NM_001260327.2. [P20482-3]
DR RefSeq; NP_001247257.1; NM_001260328.1. [P20482-3]
DR RefSeq; NP_001247259.1; NM_001260330.1. [P20482-1]
DR RefSeq; NP_001247260.1; NM_001260331.1. [P20482-1]
DR RefSeq; NP_732833.1; NM_170053.3. [P20482-1]
DR RefSeq; NP_732834.1; NM_170054.4. [P20482-2]
DR RefSeq; NP_732835.1; NM_170055.2. [P20482-3]
DR RefSeq; NP_732836.1; NM_170056.2. [P20482-3]
DR RefSeq; NP_732837.1; NM_170057.2. [P20482-3]
DR RefSeq; NP_732838.2; NM_170058.2.
DR RefSeq; NP_732839.1; NM_170059.3. [P20482-3]
DR AlphaFoldDB; P20482; -.
DR SMR; P20482; -.
DR BioGRID; 67688; 42.
DR ELM; P20482; -.
DR IntAct; P20482; 11.
DR STRING; 7227.FBpp0297671; -.
DR PaxDb; P20482; -.
DR DNASU; 42743; -.
DR EnsemblMetazoa; FBtr0306744; FBpp0297667; FBgn0262975. [P20482-3]
DR EnsemblMetazoa; FBtr0306745; FBpp0297668; FBgn0262975. [P20482-3]
DR EnsemblMetazoa; FBtr0306746; FBpp0297669; FBgn0262975. [P20482-3]
DR EnsemblMetazoa; FBtr0306747; FBpp0297670; FBgn0262975. [P20482-3]
DR EnsemblMetazoa; FBtr0306748; FBpp0297671; FBgn0262975. [P20482-1]
DR EnsemblMetazoa; FBtr0306749; FBpp0297672; FBgn0262975. [P20482-2]
DR EnsemblMetazoa; FBtr0306750; FBpp0297673; FBgn0262975. [P20482-3]
DR EnsemblMetazoa; FBtr0306751; FBpp0297674; FBgn0262975. [P20482-3]
DR EnsemblMetazoa; FBtr0306753; FBpp0297676; FBgn0262975. [P20482-1]
DR EnsemblMetazoa; FBtr0306754; FBpp0297677; FBgn0262975. [P20482-1]
DR GeneID; 42743; -.
DR KEGG; dme:Dmel_CG43286; -.
DR UCSC; CG17894-RD; d. melanogaster.
DR CTD; 42743; -.
DR FlyBase; FBgn0262975; cnc.
DR VEuPathDB; VectorBase:FBgn0262975; -.
DR eggNOG; KOG3863; Eukaryota.
DR InParanoid; P20482; -.
DR OMA; TESFCRM; -.
DR PhylomeDB; P20482; -.
DR Reactome; R-DME-8951664; Neddylation.
DR Reactome; R-DME-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-DME-9759194; Nuclear events mediated by NFE2L2.
DR Reactome; R-DME-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR BioGRID-ORCS; 42743; 0 hits in 3 CRISPR screens.
DR ChiTaRS; cnc; fly.
DR GenomeRNAi; 42743; -.
DR PRO; PR:P20482; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0262975; Expressed in crop (Drosophila) and 59 other tissues.
DR ExpressionAtlas; P20482; baseline and differential.
DR Genevisible; P20482; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0005703; C:polytene chromosome puff; IDA:FlyBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007350; P:blastoderm segmentation; IMP:FlyBase.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
DR GO; GO:0060322; P:head development; IMP:FlyBase.
DR GO; GO:0036335; P:intestinal stem cell homeostasis; IMP:FlyBase.
DR GO; GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:UniProtKB.
DR GO; GO:0007310; P:oocyte dorsal/ventral axis specification; IMP:FlyBase.
DR GO; GO:0008103; P:oocyte microtubule cytoskeleton polarization; IMP:FlyBase.
DR GO; GO:0051663; P:oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; IMP:FlyBase.
DR GO; GO:0060465; P:pharynx development; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0008359; P:regulation of bicoid mRNA localization; IMP:FlyBase.
DR GO; GO:0007317; P:regulation of pole plasm oskar mRNA localization; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IMP:FlyBase.
DR GO; GO:0006979; P:response to oxidative stress; IMP:FlyBase.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR Pfam; PF03131; bZIP_Maf; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; SSF47454; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Developmental protein; DNA-binding;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..1383
FT /note="Segmentation protein cap'n'collar"
FT /id="PRO_0000076458"
FT DOMAIN 1195..1258
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 258..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1234
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1237..1258
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1297..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..613
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..756
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1297..1377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..850
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|PubMed:12537569,
FT ECO:0000303|PubMed:1911393, ECO:0000303|PubMed:9778513"
FT /id="VSP_009458"
FT VAR_SEQ 1..578
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:9778513, ECO:0000303|Ref.6"
FT /id="VSP_009457"
FT CONFLICT 137
FT /note="G -> A (in Ref. 2; AAC72898)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="G -> S (in Ref. 2; AAC72898)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="D -> E (in Ref. 2; AAC72898)"
FT /evidence="ECO:0000305"
FT CONFLICT 309
FT /note="I -> V (in Ref. 2; AAC72898 and 6; ABE01198)"
FT /evidence="ECO:0000305"
FT CONFLICT 370
FT /note="A -> G (in Ref. 2; AAC72898)"
FT /evidence="ECO:0000305"
FT CONFLICT 583
FT /note="A -> T (in Ref. 2; AAC72898 and 6; ACV32772)"
FT /evidence="ECO:0000305"
FT CONFLICT 928
FT /note="G -> R (in Ref. 1; AAB59246)"
FT /evidence="ECO:0000305"
FT CONFLICT 935
FT /note="S -> T (in Ref. 1; AAB59246)"
FT /evidence="ECO:0000305"
FT CONFLICT 980
FT /note="N -> K (in Ref. 1; AAB59246)"
FT /evidence="ECO:0000305"
FT CONFLICT 999
FT /note="H -> Q (in Ref. 2; AAC72897)"
FT /evidence="ECO:0000305"
FT CONFLICT 1031
FT /note="S -> R (in Ref. 1; AAB59246 and 2; AAC72897)"
FT /evidence="ECO:0000305"
FT CONFLICT 1076
FT /note="G -> R (in Ref. 1; AAB59246 and 2; AAC72896/
FT AAC72897/AAC72898)"
FT /evidence="ECO:0000305"
FT CONFLICT 1118
FT /note="D -> H (in Ref. 1; AAB59246 and 2; AAC72897)"
FT /evidence="ECO:0000305"
FT CONFLICT 1199
FT /note="I -> L (in Ref. 1; AAB59246)"
FT /evidence="ECO:0000305"
FT CONFLICT 1275
FT /note="S -> W (in Ref. 1; AAB59246 and 2; AAC72897)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1383 AA; 147412 MW; 014325A4DC1C45F7 CRC64;
MISNKKSYAM KMLQLALALS LLHYNPDYLL HRWDSQLELG THGDGWELEM LRTVHRLDMD
HNPYGNRKGL SPRIEDLLNF DDPSLGGMAN GIGGCKLPPR FNGSTFVMNL HNTTGNSSVQ
TAALQDVQST SAAATGGTMV VGTGGAPTSG GQTSGSALGE IHIDTASLDP GNANHSPLHP
TSELDTFLTP HALQDQRSIW EQNLADLYDY NDLSLQTSPY ANLPLKDGQP QPSNSSHLDL
SLAALLHGFT GGSGAPLSTA ALNDSTPHPR NLGSVTNNSA GRSDDGEESL YLGRLFGEDE
DEDYEGELIG GVANACEVEG LTTDEPFGSN CFANEVEIGD DEEESEIAEV LYKQDVDLGF
SLDQEAIINA SYASGNSAAT NVKSKPEDET KSSDPSISES SGFKDTDVNA ENEASAASVD
DIEKLKALEE LQQDKDKNNE NQLEDITNEW NGIPFTIDNE TGEYIRLPLD ELLNDVLKLS
EFPLQDDLSN DPVASTSQAA AAFNENQAQR IVSETGEDLL SGEGISSKQN RNEAKNKDND
PEKADGDSFS VSDFEELQNS VGSPLFDLDE DAKKELDEML QSAVPSYHHP HPHHGHPHAH
PHSHHHASMH HAHAHHAAAA AAAHQRAVQQ ANYGGGVGVG VGVGVGVGSG TGSAFQRQPA
AGGFHHGHHQ GRMPRLNRSV SMERLQDFAT YFSPIPSMVG GVSDMSPYPH HYPGYSYQAS
PSNGAPGTPG QHGQYGSGAN ATLQPPPPPP PPHHAAMLHH PNAALGDICP TGQPHYGHNL
GSAVTSSMHL TNSSHEADGA AAAAAAYKVE HDLMYYGNTS SDINQTDGFI NSIFTDEDLH
LMDMNESFCR MVDNSTSNNS SVLGLPSSGH VSNGSGSSAQ LGAGNPHGNQ ANGASGGVGS
MSGSAVGAGA TGMTADLLAS GGAGAQGGAD RLDASSDSAV SSMGSERVPS LSDGEWGEGS
DSAQDYHQGK YGGPYDFSYN NNSRLSTATR QPPVAQKKHQ LYGKRDPHKQ TPSALPPTAP
PAAATAVQSQ SIKYEYDAGY ASSGMASGGI SEPGAMGPAL SKDYHHHQPY GMGASGSAFS
GDYTVRPSPR TSQDLVQLNH TYSLPQGSGS LPRPQARDKK PLVATKTASK GASAGNSSSV
GGNSSNLEEE HLTRDEKRAR SLNIPISVPD IINLPMDEFN ERLSKYDLSE NQLSLIRDIR
RRGKNKVAAQ NCRKRKLDQI LTLEDEVNAV VKRKTQLNQD RDHLESERKR ISNKFAMLHR
HVFQYLRDPE GNPCSPADYS LQQAADGSVY LLPREKSEGN NTATAASNAV SSASGGSLNG
HVPTQAPMHS HQSHGMQAQH VVGGMSQQQQ QQSRLPPHLQ QQHHLQSQQQ QPGGQQQQQH
RKE
