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CND1_CAEEL
ID   CND1_CAEEL              Reviewed;        1499 AA.
AC   Q9U2M1;
DT   10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 2.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Condensin complex subunit 1 {ECO:0000255|PIRNR:PIRNR017127};
DE   AltName: Full=Non-SMC condensin I complex subunit dpy-28 {ECO:0000305};
GN   Name=dpy-28 {ECO:0000312|WormBase:Y39A1B.3};
GN   ORFNames=Y39A1B.3 {ECO:0000312|WormBase:Y39A1B.3};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND MUTAGENESIS OF GLY-1122.
RX   PubMed=3779843; DOI=10.1016/0092-8674(86)90802-0;
RA   Meyer B.J., Casson L.P.;
RT   "Caenorhabditis elegans compensates for the difference in X chromosome
RT   dosage between the sexes by regulating transcript levels.";
RL   Cell 47:871-881(1986).
RN   [3] {ECO:0000305}
RP   FUNCTION, IDENTIFICATION IN A DOSAGE COMPENSATION COMPLEX, AND INTERACTION
RP   WITH MIX-1; DPY-27 AND DPY-26.
RX   PubMed=15557118; DOI=10.1083/jcb.200408061;
RA   Chan R.C., Severson A.F., Meyer B.J.;
RT   "Condensin restructures chromosomes in preparation for meiotic divisions.";
RL   J. Cell Biol. 167:613-625(2004).
RN   [4] {ECO:0000305}
RP   FUNCTION, IDENTIFICATION IN A DOSAGE COMPENSATION COMPLEX, INTERACTION WITH
RP   MIX-1; DPY-26 AND DPY-27, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP   DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=18198337; DOI=10.1101/gad.1618508;
RA   Tsai C.J., Mets D.G., Albrecht M.R., Nix P., Chan A., Meyer B.J.;
RT   "Meiotic crossover number and distribution are regulated by a dosage
RT   compensation protein that resembles a condensin subunit.";
RL   Genes Dev. 22:194-211(2008).
RN   [5] {ECO:0000305}
RP   FUNCTION, IDENTIFICATION IN A CONDENSIN I COMPLEX AND IN A DOSAGE
RP   COMPENSATION COMPLEX, INTERACTION WITH DPY-26 AND SMC-4, DISRUPTION
RP   PHENOTYPE, AND MUTAGENESIS OF GLY-1122.
RX   PubMed=19781752; DOI=10.1016/j.cell.2009.07.035;
RA   Mets D.G., Meyer B.J.;
RT   "Condensins regulate meiotic DNA break distribution, thus crossover
RT   frequency, by controlling chromosome structure.";
RL   Cell 139:73-86(2009).
RN   [6] {ECO:0000305}
RP   FUNCTION, IDENTIFICATION IN A CONDENSIN I COMPLEX AND IN A DOSAGE
RP   COMPENSATION COMPLEX, INTERACTION WITH DPY-27; DPY-26; CAPG-1 AND SMC-4,
RP   AND DISRUPTION PHENOTYPE.
RX   PubMed=19119011; DOI=10.1016/j.cub.2008.12.006;
RA   Csankovszki G., Collette K., Spahl K., Carey J., Snyder M., Petty E.,
RA   Patel U., Tabuchi T., Liu H., McLeod I., Thompson J., Sarkeshik A.,
RA   Sarkesik A., Yates J., Meyer B.J., Hagstrom K.;
RT   "Three distinct condensin complexes control C. elegans chromosome
RT   dynamics.";
RL   Curr. Biol. 19:9-19(2009).
RN   [7]
RP   FUNCTION.
RX   PubMed=23684975; DOI=10.1016/j.cub.2013.04.028;
RA   Bembenek J.N., Verbrugghe K.J., Khanikar J., Csankovszki G., Chan R.C.;
RT   "Condensin and the spindle midzone prevent cytokinesis failure induced by
RT   chromatin bridges in C. elegans embryos.";
RL   Curr. Biol. 23:937-946(2013).
RN   [8]
RP   SUMOYLATION.
RX   PubMed=24043781; DOI=10.1073/pnas.1315793110;
RA   Pferdehirt R.R., Meyer B.J.;
RT   "SUMOylation is essential for sex-specific assembly and function of the
RT   Caenorhabditis elegans dosage compensation complex on X chromosomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:E3810-E3819(2013).
RN   [9]
RP   INTERACTION WITH SMCL-1; DPY-27 AND DPY-26, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=28301465; DOI=10.1371/journal.pgen.1006614;
RA   Chao L.F., Singh M., Thompson J., Yates J.R. III, Hagstrom K.A.;
RT   "An SMC-like protein binds and regulates Caenorhabditis elegans
RT   condensins.";
RL   PLoS Genet. 13:E1006614-E1006614(2017).
CC   -!- FUNCTION: Required for both chromosome condensation and segregation
CC       during mitosis and meiosis and X-chromosome dosage compensation
CC       depending on its binding partners (PubMed:19119011, PubMed:19781752,
CC       PubMed:3779843, PubMed:18198337). Regulatory subunit of the condensin I
CC       complex, a complex required for conversion of interphase chromatin into
CC       mitotic-like condense chromosomes (PubMed:19781752, PubMed:19119011).
CC       The condensin I complex probably introduces positive supercoils into
CC       relaxed DNA in the presence of type I topoisomerases and converts
CC       nicked DNA into positive knotted forms in the presence of type II
CC       topoisomerases (By similarity). The condensin I complex function is
CC       required for proper chromosome segregation in mitosis and meiosis
CC       (PubMed:19119011). As a member of the condensin I complex, further
CC       controls the crossover number and distribution in meiosis by
CC       restricting double strand break formation, possibly by influencing
CC       higher-order chromosome structure (PubMed:18198337, PubMed:19781752).
CC       Plays a role in robust cytokinesis upon presence of chromatin
CC       obstructions (PubMed:23684975). Also a member of the condensin I-like
CC       dosage compensation complex that associates specifically with
CC       hermaphrodite X chromosomes to reduce their gene transcription during
CC       interphase, possibly through chromatin reorganization (PubMed:3779843,
CC       PubMed:19119011, PubMed:15557118). {ECO:0000250|UniProtKB:Q9YHY6,
CC       ECO:0000255|PIRNR:PIRNR017127, ECO:0000269|PubMed:15557118,
CC       ECO:0000269|PubMed:18198337, ECO:0000269|PubMed:19119011,
CC       ECO:0000269|PubMed:19781752, ECO:0000269|PubMed:23684975,
CC       ECO:0000269|PubMed:3779843}.
CC   -!- SUBUNIT: Component of the condensin I complex, which contains the mix-
CC       1/SMC2 and smc-4/SMC4 heterodimer, and three non SMC subunits that
CC       probably regulate the complex: dpy-26, capg-1 and dpy-28
CC       (PubMed:19781752, PubMed:19119011, PubMed:18198337). Within the
CC       complex, interacts with dpy-26 and smc-4 (PubMed:19781752,
CC       PubMed:19119011, PubMed:28301465). Component of the dosage compensation
CC       complex, which consist of the condensin I like components mix-1/SMC2
CC       and dpy-27/SMC4, and the three non SMC subunits dpy-26, capg-1 and dpy-
CC       28 (PubMed:18198337, PubMed:19781752, PubMed:19119011,
CC       PubMed:15557118). Within the complex, interacts with mix-1, dpy-27,
CC       dpy-26 and capg-1 (PubMed:15557118, PubMed:18198337, PubMed:19119011,
CC       PubMed:28301465). Interacts with smcl-1 (PubMed:28301465).
CC       {ECO:0000269|PubMed:15557118, ECO:0000269|PubMed:18198337,
CC       ECO:0000269|PubMed:19119011, ECO:0000269|PubMed:19781752,
CC       ECO:0000269|PubMed:28301465}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18198337}. Chromosome
CC       {ECO:0000269|PubMed:18198337}. Note=During mitosis, localizes to
CC       condensed chromosomes in both sexes. In interphase cells, diffusely
CC       distributed in nuclei of hermaphrodite embryos prior to the onset of
CC       dosage compensation. Localizes to the X chromosome after the 40-cell
CC       stage when dosage compensation is initiated in hermaphrodite (XX) but
CC       not in male (X0) embryos, where it remains diffusely nuclear.
CC       {ECO:0000269|PubMed:18198337}.
CC   -!- TISSUE SPECIFICITY: Expressed in somatic and germline tissues (at
CC       protein level). {ECO:0000269|PubMed:18198337}.
CC   -!- DEVELOPMENTAL STAGE: Associates with meiotic and mitotic chromosomes
CC       prior to the onset of dosage compensation and with hermaphrodite X
CC       chromosomes after the onset of dosage compensation (at protein level).
CC       {ECO:0000269|PubMed:18198337}.
CC   -!- PTM: Sumoylated. Sumoylated in the context of the dosage compensation
CC       complex but not in the condensin I complex. Sumoylation is important
CC       for assembly of the dosage compensation complex and its robust binding
CC       to the X chromosome. {ECO:0000269|PubMed:24043781}.
CC   -!- DISRUPTION PHENOTYPE: Results in high larval lethality in
CC       hermaphrodites, and survivors exhibit a XX-specific shorter and stouter
CC       body morphology (PubMed:18198337). Higher percentage of spontaneous
CC       males through X chromosome non-disjunction (PubMed:18198337). Increased
CC       number of crossovers, redistribution of crossovers and a reduction in
CC       crossover interference in meiosis (PubMed:18198337). Increased number
CC       of rad-51 foci in early to mid-pachytene indicating double strand break
CC       formation (PubMed:18198337, PubMed:19781752). Increase in X chromosome
CC       axis length indicating aberrant chromosome structure (PubMed:19781752).
CC       RNAi-mediated knockdown results in chromosome segregation defects in
CC       mitosis (PubMed:19119011). {ECO:0000269|PubMed:18198337,
CC       ECO:0000269|PubMed:19119011, ECO:0000269|PubMed:19781752}.
CC   -!- SIMILARITY: Belongs to the CND1 (condensin subunit 1) family.
CC       {ECO:0000255|PIRNR:PIRNR017127}.
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DR   EMBL; BX284603; CAA16340.3; -; Genomic_DNA.
DR   PIR; C88589; C88589.
DR   PIR; T26747; T26747.
DR   RefSeq; NP_499379.2; NM_066978.4.
DR   AlphaFoldDB; Q9U2M1; -.
DR   SMR; Q9U2M1; -.
DR   ComplexPortal; CPX-1271; Condensin I complex.
DR   ComplexPortal; CPX-1273; Condensin I-like dosage compensation complex.
DR   IntAct; Q9U2M1; 4.
DR   STRING; 6239.Y39A1B.3; -.
DR   EPD; Q9U2M1; -.
DR   PaxDb; Q9U2M1; -.
DR   PeptideAtlas; Q9U2M1; -.
DR   EnsemblMetazoa; Y39A1B.3.1; Y39A1B.3.1; WBGene00001087.
DR   GeneID; 176509; -.
DR   KEGG; cel:CELE_Y39A1B.3; -.
DR   UCSC; Y39A1B.3; c. elegans.
DR   CTD; 176509; -.
DR   WormBase; Y39A1B.3; CE31734; WBGene00001087; dpy-28.
DR   eggNOG; KOG0414; Eukaryota.
DR   GeneTree; ENSGT00940000153566; -.
DR   HOGENOM; CLU_004539_0_0_1; -.
DR   InParanoid; Q9U2M1; -.
DR   OMA; DVIAKLW; -.
DR   OrthoDB; 166920at2759; -.
DR   PhylomeDB; Q9U2M1; -.
DR   Reactome; R-CEL-2514853; Condensation of Prometaphase Chromosomes.
DR   PRO; PR:Q9U2M1; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00001087; Expressed in embryo and 4 other tissues.
DR   GO; GO:0000779; C:condensed chromosome, centromeric region; IBA:GO_Central.
DR   GO; GO:0000794; C:condensed nuclear chromosome; IDA:WormBase.
DR   GO; GO:0000796; C:condensin complex; IPI:ComplexPortal.
DR   GO; GO:0046536; C:dosage compensation complex; IPI:WormBase.
DR   GO; GO:0043073; C:germ cell nucleus; IDA:WormBase.
DR   GO; GO:0005654; C:nucleoplasm; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0000805; C:X chromosome; IDA:WormBase.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IMP:WormBase.
DR   GO; GO:0042464; P:dosage compensation by hypoactivation of X chromosome; IC:ComplexPortal.
DR   GO; GO:0010032; P:meiotic chromosome condensation; IBA:GO_Central.
DR   GO; GO:0045132; P:meiotic chromosome segregation; IC:ComplexPortal.
DR   GO; GO:0045144; P:meiotic sister chromatid segregation; IMP:WormBase.
DR   GO; GO:0007076; P:mitotic chromosome condensation; IBA:GO_Central.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IMP:WormBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; IC:ComplexPortal.
DR   GO; GO:0045128; P:negative regulation of reciprocal meiotic recombination; IMP:WormBase.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR026971; CND1/NCAPD3.
DR   InterPro; IPR032682; Cnd1_C.
DR   InterPro; IPR007673; Condensin_cplx_su1.
DR   PANTHER; PTHR14222; PTHR14222; 1.
DR   PANTHER; PTHR14222:SF2; PTHR14222:SF2; 1.
DR   Pfam; PF12717; Cnd1; 1.
DR   PIRSF; PIRSF017127; Condensin_D2; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Chromosome; DNA condensation; Meiosis; Mitosis;
KW   Nucleus; Reference proteome; Ubl conjugation.
FT   CHAIN           1..1499
FT                   /note="Condensin complex subunit 1"
FT                   /id="PRO_0000439858"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1421..1499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1424..1448
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1467..1489
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         1122
FT                   /note="G->E: In y1; leads to XX-specific lethality.
FT                   Surviving hermaphrodites exhibit increased X-linked gene
FT                   transcripts and a shorter and stouter body morphology. XO
FT                   animals are wild-type males. Defects in mitotic chromosome
FT                   segregation."
FT                   /evidence="ECO:0000269|PubMed:19781752,
FT                   ECO:0000269|PubMed:3779843"
SQ   SEQUENCE   1499 AA;  171022 MW;  779D91C23166E355 CRC64;
     MPRKQRVVTT PSPPTSDEDE DMDFGSTSQQ QQQQPTRNND GLSGFKSITE IIAEADNNIP
     SEQIDKDIDS FSSYSDISDW RGIPKFFPSL SSLSRRASTY ENWENRFKVV DYLVSCSGAL
     KDSVSDYVAD YFEKNESGED HSVDVELVHA VSMFVILTQR LTVQLQLYVS KSIASANQQA
     KRGTGRGGRQ VDLDDDIVKW KDIQRHRMIN CLLELLELRV DTVAGTKKKA IQYVFAPDVM
     EKDFLLRFLD TVVQLLEDPE NMARSSQQWI SHYFRILKVL SADYGMTKDV ANCLFTALSH
     SYLEAANTFP FIEPLVTLMK ENGEGSGRIY QPLRNVLQLV ICRVGNLYAG ERAEKPPPKA
     FCMMVQSLAI NVHDLMLQDI THVYRLLQNQ HVNVRMSTLH ALADMFSSSY LSQSLCDTFA
     SRRLKREGIF KRLLAHTNDE ATNVRSKAVS LLRNIMENRR IPEEFESCGL LSIVGSRLND
     KSVQVRKSAI QFLTTFLDNN RHGHDFNREM HQLKLNAKCS ELRNAEEPQS KAIQGAENAF
     RQNLFTLTAG VRVEVYDIFR RRYRVEPERS ITDILTGLFS PGSGNRLVRY YVAQENFPFR
     DRIPSLRERR SDDMEDDDDD TVSLEDDDMT SLVSEVVKWV VAQAEEDYVT FKVQLTQMDD
     DQLLENEQEA RDRNNQIMQL RAQVQQLINK MSIEQELSRC VTIALRCVLN GETAEIKEGI
     RFLTRCKLFE ITGADDAIRS MCSLVWRPSA DILNELIEAA EDMFISRLDG NEKASERDSS
     TVENLMKAMN GVTEKDRPSV EEVIYLLAAT ELVHVDSDKN KVPRKRRPIE ANVINKLWMI
     ALDMSHGINS RKIDALRILY PISRSERGIA EARSRLRVVQ KKLMDPELAV DALRIISILG
     TPTKLENEQD AYSRPLFKIH QDDSLWKSIE KLFFYEIMKA DDNPDRDWFG VIRLTITTIL
     SLSMDVNVML PKLASHFVYR TKRISDFFLF YCDQVDDATD DTRKKMAQRR REYWALTYCR
     VMEKLMAFIG EVAVQLNAYI QVTIPKLHTR YVSKMVDAEK NDANIREEPV RFLSDLEKSV
     AQRKTIFTVP QDTTPGATSN DLHHLVSVMC DKRLFVPNKL MGRLLPIVVY GMRCKIMPTR
     IRHAATVAYG KMMPLSAEIS AFAAPSFFSA MTKSSSILLR CNLVAACCDF AFAQPTLFEL
     FAQSLFRMSQ DESPLAREST ILVLSHLMSN DMIQTRGVLS EAARCICDPT RAVRDVAQSF
     FKELNSRTDT IIQLLPEFLY HLSNGNERMS FKSYKTVFEF LIQLLKDKPK ASADSMIDRV
     CIKFSNTDMN DSETPKYLLV ALAKFVQNDG GLHRLQDNWR HWSKFMCHPS VAKEYRMMVE
     HMHSTSKNDE FKSQCVELID NINKIESEGL RKEDVAIGSS ITKNKGRAKK NPTTMSGSSR
     TTSRAANSRR RAPPPAQSDE DDSDSDDAPA APRSAARRKA KKSAVADDDS DSDEFMLDD
 
 
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