ID   ACKMT_CAEEL             Reviewed;         190 AA.
AC   Q9XX11;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   11-NOV-2015, sequence version 2.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=ATP synthase subunit C lysine N-methyltransferase;
DE            EC=2.1.1.- {ECO:0000269|PubMed:30530489};
GN   ORFNames=Y39A1A.21 {ECO:0000312|WormBase:Y39A1A.21a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, AND CATALYTIC ACTIVITY.
RX   PubMed=30530489; DOI=10.1074/jbc.ra118.005473;
RA   Malecki J.M., Willemen H.L.D.M., Pinto R., Ho A.Y.Y., Moen A.,
RA   Kjoenstad I.F., Burgering B.M.T., Zwartkruis F., Eijkelkamp N.,
RA   Falnes P.O.;
RT   "Lysine methylation by the mitochondrial methyltransferase FAM173B
RT   optimizes the function of mitochondrial ATP synthase.";
RL   J. Biol. Chem. 294:1128-1141(2019).
CC   -!- FUNCTION: Mitochondrial protein-lysine N-methyltransferase that
CC       trimethylates ATP synthase subunit C. Trimethylation is required for
CC       proper incorporation of the C subunit into the ATP synthase complex and
CC       mitochondrial respiration. {ECO:0000269|PubMed:30530489}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) +
CC         N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA-
CC         COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61961;
CC         Evidence={ECO:0000269|PubMed:30530489};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193;
CC         Evidence={ECO:0000269|PubMed:30530489};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q6P4H8}.
CC   -!- SIMILARITY: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; BX284603; CAA21030.2; -; Genomic_DNA.
DR   PIR; T26741; T26741.
DR   RefSeq; NP_001022840.2; NM_001027669.4.
DR   AlphaFoldDB; Q9XX11; -.
DR   SMR; Q9XX11; -.
DR   STRING; 6239.Y39A1A.21a; -.
DR   EPD; Q9XX11; -.
DR   PaxDb; Q9XX11; -.
DR   PeptideAtlas; Q9XX11; -.
DR   EnsemblMetazoa; Y39A1A.21a.1; Y39A1A.21a.1; WBGene00012658.
DR   EnsemblMetazoa; Y39A1A.21a.2; Y39A1A.21a.2; WBGene00012658.
DR   UCSC; Y39A1A.21a; c. elegans.
DR   WormBase; Y39A1A.21a; CE50211; WBGene00012658; -.
DR   eggNOG; KOG4058; Eukaryota.
DR   GeneTree; ENSGT00390000014771; -.
DR   HOGENOM; CLU_068443_4_0_1; -.
DR   InParanoid; Q9XX11; -.
DR   OMA; GVNTVWF; -.
DR   OrthoDB; 1605787at2759; -.
DR   PRO; PR:Q9XX11; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00012658; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q9XX11; baseline and differential.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IMP:UniProtKB.
DR   GO; GO:0018023; P:peptidyl-lysine trimethylation; IMP:UniProtKB.
DR   GO; GO:1905273; P:positive regulation of proton-transporting ATP synthase activity, rotational mechanism; IMP:UniProtKB.
DR   GO; GO:1905706; P:regulation of mitochondrial ATP synthesis coupled proton transport; IMP:UniProtKB.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR026170; FAM173A/B.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR13610; PTHR13610; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase; Mitochondrion; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..190
FT                   /note="ATP synthase subunit C lysine N-methyltransferase"
FT                   /id="PRO_0000446890"
SQ   SEQUENCE   190 AA;  20493 MW;  E04442599C578DD7 CRC64;
     MGMNTGLVIA GVAGATALAI SAAAIPFVAP ALRRVCIPYV PATTEQLANV SRALSLATSS
     NSNKKGTLID LGSGDGRVVL QCAREGFNST GVELNSILVA YSKYRSIREG LGKETRFMRK
     NIFKTDLNPY QTAVIFGAES LMGDLVPKLS EMRSNTNLLA CRFPLPENDA WKLEHQIGEG
     IDAVWVYKRN