ID   CNDG2_XENLA             Reviewed;        1156 AA.
AC   Q2TAW0; Q4QR24; Q68F16;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Condensin-2 complex subunit G2;
DE   AltName: Full=Chromosome-associated protein G2;
DE   AltName: Full=Non-SMC condensin II complex subunit G2;
DE   AltName: Full=XCAP-G2;
GN   Name=ncapg2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION IN CONDENSIN-2 COMPLEX WITH SMC2; SMC4; NCAPG2; NCAPH2 AND
RP   NCAPD3, AND FUNCTION OF THE COMPLEX.
RX   PubMed=14532007; DOI=10.1016/s0092-8674(03)00724-4;
RA   Ono T., Losada A., Hirano M., Myers M.P., Neuwald A.F., Hirano T.;
RT   "Differential contributions of condensin I and condensin II to mitotic
RT   chromosome architecture in vertebrate cells.";
RL   Cell 115:109-121(2003).
CC   -!- FUNCTION: Regulatory subunit of the condensin-2 complex, a complex
CC       which establishes mitotic chromosome architecture and is involved in
CC       physical rigidity of the chromatid axis. {ECO:0000250,
CC       ECO:0000269|PubMed:14532007}.
CC   -!- SUBUNIT: Component of the condensin-2 complex, which contains the smc2
CC       and smc4 heterodimer, and three non SMC subunits that probably regulate
CC       the complex: ncaph2, ncapd3 and ncapg2. {ECO:0000305|PubMed:14532007}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC080030; AAH80030.1; -; mRNA.
DR   EMBL; BC097657; AAH97657.1; -; mRNA.
DR   EMBL; BC110705; AAI10706.1; -; mRNA.
DR   RefSeq; NP_001086462.1; NM_001092993.1.
DR   AlphaFoldDB; Q2TAW0; -.
DR   BioGRID; 103144; 3.
DR   DIP; DIP-48590N; -.
DR   IntAct; Q2TAW0; 1.
DR   DNASU; 446284; -.
DR   GeneID; 446284; -.
DR   KEGG; xla:446284; -.
DR   CTD; 446284; -.
DR   Xenbase; XB-GENE-1002747; ncapg2.L.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 446284; Expressed in ovary and 17 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024741; Condensin2_G2.
DR   Pfam; PF12422; Condensin2nSMC; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; DNA condensation; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..1156
FT                   /note="Condensin-2 complex subunit G2"
FT                   /id="PRO_0000255944"
FT   REPEAT          460..498
FT                   /note="HEAT"
FT   REGION          587..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        589..603
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        131
FT                   /note="H -> Y (in Ref. 1; AAH80030)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        193
FT                   /note="T -> A (in Ref. 1; AAH80030)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1156 AA;  131374 MW;  15EA008EEDD09F08 CRC64;
     MSKREAFLQA TAKDSVEDFL SFIQLHKDVS DPFDLNELLQ ELSRKQKEEL WEKLKTLLTE
     ALVANPVERW QNIDDDSDDD MEVESSSDVK QTMCVIHGVT IAAAASLCVI DEDVCYETLL
     ECAAILSGIV HALPKSESHI TLAIRHLCEA WWEKGLQGKE EFGKTAFLLL LAKSLEVKCV
     VADIGRLWHL HQTLLSFDFN SEESHNVKDL LLQCFLSINH IKKEEGRRFL SFLFSWDVNF
     IKMIHGTIKN QLQCLPKSLM THIADIYFRA WKKASGDVLQ TIEQSCIQDF MHHGVHLPRN
     SPLHPKVREV LSYFHQQKLR QGVEEMLYNL YQPIIWRGLK ARNSEVRSNA ALLFVEAFPI
     RDPNLNHEDM DNEIQKQFEE LFNLLEDPQP LVRSTGVLGV CKITAKYWEM IPPAILTDLL
     RKILGDLAAD VSSADVRCSV FKCLPILLDN KLSHPLLENM LPALKFCLHD NSEKVRVAFV
     DMLLKIKAVR AAKFWKICPM EQILARLEVD SRPVSRRIVN LLFNSFFPVN QQEEVWCERC
     VALIQMNPAA ARKFYQYAYE HTAPTNIAKL MLTIRRCLNA CINRTVPNED TEDEDDDEGD
     GEGIVRGDSE KENKSVLENV LSTEDSASMA SLLEIVVVLW RSIRKALDQN EEAKTYTISK
     FASVLPEYFK AFKEERCTVP LIILASFMPP AAVPTFSCSV LSKLRHLDSG ADEQKYSTLI
     DCLCRWGQVG HVLELASEWL SESYPEKRGR KDSNRQVRIQ DTMESKPALA LDYIEYIMTH
     TMNRDCLLSL QTKKLNQLLK VLGLVKEVLF CYIKPSEAVT HNVNQDTALR AFSLYCRLSI
     HLQHKFSSEG RTYLSVLEDT GGWIESQVLP TLESNQDISE EPRNMCHQIL KAYLTVCKDV
     LMVGLADSEF QAQLLQITLS VIQTEKCHNC LPMLFYVLKE ITELCLAHKM SDASVECDEM
     LDAIQKAFHK SLETVARRLR KQREEALQLL QTIQLPLGEF VHTVQCWHTA SKVLHRGTLS
     TLLAAVVVEI SHSLRKITDL SELTPPSSIS DLPPLSKCIM TIIVKSPSAV SSFLDELTEC
     ITLEEVEGIL SLTAALYVAV VSSKRKQIPP AVKNTASAIY RKLKNFCEVT MDDAGSIERA
     VYESSMRILN EMLHPS