CNDH2_ARATH
ID CNDH2_ARATH Reviewed; 683 AA.
AC Q9LUR0;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Condensin-2 complex subunit H2;
DE AltName: Full=Chromosome-associated protein H2;
DE Short=AtCAP-H2;
DE AltName: Full=Non-SMC condensin II complex subunit H2;
DE AltName: Full=Protein HYPERSENSITIVE TO EXCESS BORON 2;
DE Short=Hypersensitive to excess B 2;
GN Name=CAPH2; Synonyms=HEB2; OrderedLocusNames=At3g16730; ORFNames=MGL6.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=15883832; DOI=10.1007/s00425-005-1546-0;
RA Fujimoto S., Yonemura M., Matsunaga S., Nakagawa T., Uchiyama S., Fukui K.;
RT "Characterization and dynamic analysis of Arabidopsis condensin subunits,
RT AtCAP-H and AtCAP-H2.";
RL Planta 222:293-300(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION BY BORON EXCESS.
RC STRAIN=cv. Columbia;
RX PubMed=21917552; DOI=10.1105/tpc.111.086314;
RA Sakamoto T., Inui Y.T., Uraguchi S., Yoshizumi T., Matsunaga S., Mastui M.,
RA Umeda M., Fukui K., Fujiwara T.;
RT "Condensin II alleviates DNA damage and is essential for tolerance of boron
RT overload stress in Arabidopsis.";
RL Plant Cell 23:3533-3546(2011).
CC -!- FUNCTION: Regulatory subunit of the condensin-2 complex, a complex that
CC seems to provide chromosomes with an additional level of organization
CC and rigidity and in establishing mitotic chromosome architecture (By
CC similarity). The condensin-2 complex plays a role in DNA damage repair
CC or in protecting the genome from certain genotoxic stressors (e.g.
CC boron excess, zeocin and aphidicolin). {ECO:0000250,
CC ECO:0000269|PubMed:21917552}.
CC -!- SUBUNIT: Component of the condensin-2 complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15883832}.
CC Chromosome {ECO:0000269|PubMed:15883832}. Note=Localized at mitotic
CC chromosomes from pro-metaphase to telophase. During interphase, mainly
CC found in nucleolus.
CC -!- TISSUE SPECIFICITY: Expressed in seedlings, roots, stems, leaves,
CC flower buds and flowers. {ECO:0000269|PubMed:15883832}.
CC -!- INDUCTION: By boron excess (B). {ECO:0000269|PubMed:21917552}.
CC -!- DISRUPTION PHENOTYPE: Enhanced sensitivity to excess boron (B), to
CC zeocin, which induces DNA double-strand breaks (DSBs), and to
CC aphidicolin, which blocks DNA replication, probably due to the
CC accumulation of DSBs. Reduced root length, especially in the presence
CC of genotoxic stressors, with twisted shape, ectopic lateral root
CC formation and dense root hairs, as well as short meristematic zones.
CC {ECO:0000269|PubMed:21917552}.
CC -!- SIMILARITY: Belongs to the CND2 H2 (condensin-2 subunit 2) family.
CC {ECO:0000305}.
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DR EMBL; AB193291; BAD95574.1; -; mRNA.
DR EMBL; AB022217; BAB02765.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75858.1; -; Genomic_DNA.
DR EMBL; AK226817; BAE98913.1; -; mRNA.
DR RefSeq; NP_188295.2; NM_112546.4.
DR AlphaFoldDB; Q9LUR0; -.
DR SMR; Q9LUR0; -.
DR STRING; 3702.AT3G16730.1; -.
DR iPTMnet; Q9LUR0; -.
DR PaxDb; Q9LUR0; -.
DR PRIDE; Q9LUR0; -.
DR ProteomicsDB; 220289; -.
DR EnsemblPlants; AT3G16730.1; AT3G16730.1; AT3G16730.
DR GeneID; 820925; -.
DR Gramene; AT3G16730.1; AT3G16730.1; AT3G16730.
DR KEGG; ath:AT3G16730; -.
DR Araport; AT3G16730; -.
DR TAIR; locus:2089298; AT3G16730.
DR eggNOG; KOG2359; Eukaryota.
DR HOGENOM; CLU_018318_0_0_1; -.
DR InParanoid; Q9LUR0; -.
DR OMA; PPEHKLK; -.
DR OrthoDB; 522566at2759; -.
DR PhylomeDB; Q9LUR0; -.
DR PRO; PR:Q9LUR0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LUR0; baseline and differential.
DR Genevisible; Q9LUR0; AT.
DR GO; GO:0000793; C:condensed chromosome; IDA:UniProtKB.
DR GO; GO:0000796; C:condensin complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0010032; P:meiotic chromosome condensation; IBA:GO_Central.
DR GO; GO:0051306; P:mitotic sister chromatid separation; IBA:GO_Central.
DR GO; GO:0045739; P:positive regulation of DNA repair; IMP:UniProtKB.
DR GO; GO:2001022; P:positive regulation of response to DNA damage stimulus; IMP:UniProtKB.
DR Gene3D; 1.10.10.580; -; 1.
DR InterPro; IPR031737; CNDH2_C.
DR InterPro; IPR031719; H2_M.
DR InterPro; IPR009378; H2_N.
DR InterPro; IPR031739; Ncaph2.
DR InterPro; IPR023093; ScpA-like_C.
DR PANTHER; PTHR14324; PTHR14324; 1.
DR Pfam; PF16858; CNDH2_C; 1.
DR Pfam; PF16869; CNDH2_M; 1.
DR Pfam; PF06278; CNDH2_N; 1.
PE 2: Evidence at transcript level;
KW Chromosome; DNA condensation; Nucleus; Reference proteome.
FT CHAIN 1..683
FT /note="Condensin-2 complex subunit H2"
FT /id="PRO_0000419280"
FT REGION 96..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 75865 MW; C9B15D1B42232FBA CRC64;
MTSHGGGEVR GERIHTVQPE RDLVANWEVD LSEKLEEYLL KICSGEITGN EEDGQIPVNF
AEAALLLQGS VQVYSKKVEY LYNLVLRTLE FLSKQRDQEQ SKGTSNENEA SSSRQVDEEE
NDLFWNVDDI PVDTKNRLDS SVGGDTCPSQ FVKPPANLVV LEGDCLDTSG DGGELESYLL
ATTHLYRDFI LLDPCDAVAV NEFLGDNYGG KGRNSAHRGS SVRKSFHSSV GRSGGSARKS
SVGKNQGTNV HLSPICGNGP NDQNCDQGSQ PPVFEDNDHG FDMDNEYGGA MDFSDTDADE
DDPWKPLNPY EPGKLKVKPF KKVKILKKIG WSITKDHMTS MFPLARPNGP ISSELIEIWK
MHGCASKDEQ ASQDIPYYEK LREMLVNGGN QPCGANGNYN DNDKDNHDEA NNGDFHDFGE
HDGDDAEHPF MDEDVLNMND GGAAEFHNYD GFENGESNCQ ESLEDLCRSH LDALLANIAK
SEKQTDLAAR VSTWKQKIEQ NLEEQELHPP FDIQEYGDRI INKLTVEESG NVETFTDLMK
DQEKHEVARA FSALLQLVNN GDVDLEKPGN STNEPMCYTA VKPFSVRLLK VHNRKNEKRG
IHLPQKRAKS PITKGKSHES PPPKKRNTCS VSSQTRKVSL KISKINGVGV RCTPNSKKRR
KGRSDDVTEV TEVASIEKSL GKL
