CNDH2_DANRE
ID CNDH2_DANRE Reviewed; 592 AA.
AC Q5RH01; A6H8R1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Condensin-2 complex subunit H2;
DE AltName: Full=Non-SMC condensin II complex subunit H2;
GN Name=ncaph2; ORFNames=si:dkey-202b22.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulatory subunit of the condensin-2 complex, a complex that
CC seems to provide chromosomes with an additional level of organization
CC and rigidity and in establishing mitotic chromosome architecture.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the condensin-2 complex, which contains the smc2
CC and smc4 heterodimer, and three non SMC subunits, ncapg2, ncaph2 and
CC ncapd3 that probably regulate the complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CND2 H2 (condensin-2 subunit 2) family.
CC {ECO:0000305}.
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DR EMBL; BX649398; CAI20824.1; -; Genomic_DNA.
DR EMBL; BC146715; AAI46716.1; -; mRNA.
DR RefSeq; NP_001038456.1; NM_001044991.1.
DR RefSeq; XP_009298568.1; XM_009300293.2.
DR AlphaFoldDB; Q5RH01; -.
DR STRING; 7955.ENSDARP00000040826; -.
DR PaxDb; Q5RH01; -.
DR PRIDE; Q5RH01; -.
DR Ensembl; ENSDART00000040827; ENSDARP00000040826; ENSDARG00000033757.
DR Ensembl; ENSDART00000190819; ENSDARP00000149771; ENSDARG00000033757.
DR GeneID; 562678; -.
DR KEGG; dre:562678; -.
DR CTD; 29781; -.
DR ZFIN; ZDB-GENE-041210-172; ncaph2.
DR eggNOG; KOG2359; Eukaryota.
DR GeneTree; ENSGT00390000014443; -.
DR HOGENOM; CLU_010569_0_0_1; -.
DR InParanoid; Q5RH01; -.
DR OMA; PPEHKLK; -.
DR OrthoDB; 522566at2759; -.
DR PhylomeDB; Q5RH01; -.
DR TreeFam; TF101164; -.
DR Reactome; R-DRE-2299718; Condensation of Prophase Chromosomes.
DR PRO; PR:Q5RH01; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000033757; Expressed in testis and 19 other tissues.
DR GO; GO:0000796; C:condensin complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0010032; P:meiotic chromosome condensation; IBA:GO_Central.
DR GO; GO:0051306; P:mitotic sister chromatid separation; IBA:GO_Central.
DR InterPro; IPR031737; CNDH2_C.
DR InterPro; IPR009378; H2_N.
DR InterPro; IPR031739; Ncaph2.
DR PANTHER; PTHR14324; PTHR14324; 1.
DR Pfam; PF16858; CNDH2_C; 1.
DR Pfam; PF06278; CNDH2_N; 1.
PE 2: Evidence at transcript level;
KW DNA condensation; Nucleus; Reference proteome.
FT CHAIN 1..592
FT /note="Condensin-2 complex subunit H2"
FT /id="PRO_0000326244"
FT REGION 89..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 105
FT /note="Q -> K (in Ref. 2; AAI46716)"
FT /evidence="ECO:0000305"
FT CONFLICT 110
FT /note="S -> N (in Ref. 2; AAI46716)"
FT /evidence="ECO:0000305"
FT CONFLICT 223
FT /note="A -> V (in Ref. 2; AAI46716)"
FT /evidence="ECO:0000305"
FT CONFLICT 226..227
FT /note="AN -> VS (in Ref. 2; AAI46716)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 592 AA; 67027 MW; 41B5D27548A7ABCB CRC64;
MDSVETRYAH LLQPLRDLTK NWDIDLASQL GEYLEELDQM TISFDGGKTM MNFAEAALLI
QGSTCIYGRK VELLHTLVFQ TLDYISNKNK KRDKQGSSSD GNQEQAPSGS EGDGCEFDEI
EQDENVNTHN ITMKDPTEPV RIIRLPPESL IPAESHEKQK YPLLSLKGEL LGSCKDFRIN
TFTMDEAGLM RLGSNTHFLK GVAEVQRDFS VHLPEPLQIE GEAAAANGGY DEEVDGGAEV
LPPLEDHGME VESDEWVERH EAPSEGRMLR PRPAVQPVSE EPKQLKETVD PWKLHDPYAT
FGEDKPLKAG KCYKVPAGLD ESGKRKRKGP SKLQDFGTWF NKAFETADRK LKNGPTFPDL
NYIFVSKMDQ RLKVQRQMLR KRGVFVSDEE LKKTYLEPEN VEDQVEVIRH PDADGDDYSD
EEHDNLADDL EPAEHLDDQE QIFQDLHMSR MSYEDLVKKS VDLFLVNSQK YAQETALSRR
VKDWEDSINP HLAAQEISPA FDIHEYGDRI VHALSNVGVK KSFAFVVRGK ENTEACRYML
AALQLANDYT VEVDKVDGLD CSVDTMELTL LTTQRAHERL KTYNATAATD IP
