ID   CNDH2_XENLA             Reviewed;         624 AA.
AC   Q641G4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Condensin-2 complex subunit H2;
DE   AltName: Full=Non-SMC condensin II complex subunit H2;
GN   Name=ncaph2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION IN CONDENSIN-2 COMPLEX WITH SMC2; SMC4; NCAPG2; NCAPH2 AND
RP   NCAPD3, AND FUNCTION OF THE COMPLEX.
RX   PubMed=14532007; DOI=10.1016/s0092-8674(03)00724-4;
RA   Ono T., Losada A., Hirano M., Myers M.P., Neuwald A.F., Hirano T.;
RT   "Differential contributions of condensin I and condensin II to mitotic
RT   chromosome architecture in vertebrate cells.";
RL   Cell 115:109-121(2003).
CC   -!- FUNCTION: Regulatory subunit of the condensin-2 complex, a complex that
CC       seems to provide chromosomes with an additional level of organization
CC       and rigidity and in establishing mitotic chromosome architecture.
CC       {ECO:0000250, ECO:0000269|PubMed:14532007}.
CC   -!- SUBUNIT: Component of the condensin-2 complex, which contains the smc2
CC       and smc4 heterodimer, and three non SMC subunits, ncapg2, ncaph2 and
CC       ncapd3 that probably regulate the complex.
CC       {ECO:0000269|PubMed:14532007}.
CC   -!- INTERACTION:
CC       Q641G4; Q6GN08: ncapd3.L; NbExp=3; IntAct=EBI-15815355, EBI-15815299;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CND2 H2 (condensin-2 subunit 2) family.
CC       {ECO:0000305}.
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DR   EMBL; BC082373; AAH82373.1; -; mRNA.
DR   RefSeq; NP_001087848.1; NM_001094379.1.
DR   AlphaFoldDB; Q641G4; -.
DR   BioGRID; 104569; 4.
DR   DIP; DIP-48589N; -.
DR   IntAct; Q641G4; 1.
DR   DNASU; 447709; -.
DR   GeneID; 447709; -.
DR   KEGG; xla:447709; -.
DR   CTD; 447709; -.
DR   Xenbase; XB-GENE-993069; ncaph2.L.
DR   OrthoDB; 522566at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 447709; Expressed in blastula and 17 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   InterPro; IPR031737; CNDH2_C.
DR   InterPro; IPR031719; H2_M.
DR   InterPro; IPR009378; H2_N.
DR   InterPro; IPR031739; Ncaph2.
DR   PANTHER; PTHR14324; PTHR14324; 1.
DR   Pfam; PF16858; CNDH2_C; 1.
DR   Pfam; PF16869; CNDH2_M; 1.
DR   Pfam; PF06278; CNDH2_N; 1.
PE   1: Evidence at protein level;
KW   DNA condensation; Nucleus; Reference proteome.
FT   CHAIN           1..624
FT                   /note="Condensin-2 complex subunit H2"
FT                   /id="PRO_0000326245"
FT   REGION          429..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  71197 MW;  2C5C514EB6053868 CRC64;
     MDDAESRFTH LLQPVRDLTK NWEVDVAAQL GEYLEELDQI CISFDGGKTT MNFAEAALLI
     QGSACIYSKK VEYLYSLVYQ ALDFISNKKR VQQPTSVGAD GEDKDATFAH RNDEEEFLSL
     DDIDSKKTNV DLKKDHILNV VNIVPLTPMA LVPPEEVEKK NNPLCSRKGE VLASRKDFRM
     NTCTPHPSGA FMLELVGKSP MQFLKHIQHQ EEVSLTQGEQ NAIPEGENDN MESEKSDCAD
     PVQVLQFSDE GAPAVENGDG TGFLPLDDHD EAGDGEVEQA EHIERRKMQI DERGYILRDR
     VAEQKPTPAI KNETPDPWCV LDPFESCEEK PFKKGKHYTL PRGIAEDLSS NKRKRKLPCK
     LQDFMKWFSS THWDGSEAMK SRRKGPTFAD MEVLYWKHIK ERMTAQRQLH RRMGAQFVKE
     VTLLNEEEEL VDPLEEPRDA DCLEYDGPAD DASDNEDLGE NVPACLREEP ALGDIEPVTL
     QDQLSYEELV RRNVDLFIAN SQKYAQETVL SLRVREWEDK MGPQLQEQEE HSAFDIHDYG
     DRLTAQYSRV GEWHTFASLM ADKEPYEVCR YMLASLQLAN DYTVEVSQKP GLHEGLDTMA
     LRLLSQQRAH ERFKTYTAPS ISQQ