ID   CNDH2_XENTR             Reviewed;         624 AA.
AC   Q28GV1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Condensin-2 complex subunit H2;
DE   AltName: Full=Non-SMC condensin II complex subunit H2;
GN   Name=ncaph2; ORFNames=TEgg019e13.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory subunit of the condensin-2 complex, a complex that
CC       seems to provide chromosomes with an additional level of organization
CC       and rigidity and in establishing mitotic chromosome architecture.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the condensin-2 complex, which contains the smc2
CC       and smc4 heterodimer, and three non SMC subunits, ncapg2, ncaph2 and
CC       ncapd3 that probably regulate the complex.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CND2 H2 (condensin-2 subunit 2) family.
CC       {ECO:0000305}.
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DR   EMBL; CR761216; CAJ82082.1; -; mRNA.
DR   EMBL; BC135870; AAI35871.1; -; mRNA.
DR   RefSeq; NP_001037964.1; NM_001044499.1.
DR   RefSeq; XP_012814617.1; XM_012959163.2.
DR   AlphaFoldDB; Q28GV1; -.
DR   PaxDb; Q28GV1; -.
DR   DNASU; 733729; -.
DR   Ensembl; ENSXETT00000049937; ENSXETP00000049937; ENSXETG00000023090.
DR   GeneID; 733729; -.
DR   KEGG; xtr:733729; -.
DR   CTD; 29781; -.
DR   Xenbase; XB-GENE-993063; ncaph2.
DR   eggNOG; KOG2359; Eukaryota.
DR   HOGENOM; CLU_010569_0_0_1; -.
DR   InParanoid; Q28GV1; -.
DR   OrthoDB; 522566at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023090; Expressed in egg cell and 9 other tissues.
DR   GO; GO:0000796; C:condensin complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0010032; P:meiotic chromosome condensation; IBA:GO_Central.
DR   GO; GO:0051306; P:mitotic sister chromatid separation; IBA:GO_Central.
DR   InterPro; IPR031737; CNDH2_C.
DR   InterPro; IPR031719; H2_M.
DR   InterPro; IPR009378; H2_N.
DR   InterPro; IPR031739; Ncaph2.
DR   PANTHER; PTHR14324; PTHR14324; 1.
DR   Pfam; PF16858; CNDH2_C; 1.
DR   Pfam; PF16869; CNDH2_M; 1.
DR   Pfam; PF06278; CNDH2_N; 1.
PE   2: Evidence at transcript level;
KW   DNA condensation; Nucleus; Reference proteome.
FT   CHAIN           1..624
FT                   /note="Condensin-2 complex subunit H2"
FT                   /id="PRO_0000326246"
FT   REGION          215..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          252..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..287
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  71037 MW;  D0DC00809F28A491 CRC64;
     MDDAESRFTH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDGGKTT MNFAEAALLI
     QGSACIYSKK VEYLYSLVYQ ALDFISNKKR DQQPASVGAD GVDKDATFAH RNDEEEFLSL
     DDIIDPKKTN VDIKKDQVLH VVNIVPLTPM ALVPPEETEK KNNPLCSRKG EVLASRKDFR
     MNTCTPHPSG AFMLELAGKS PMQFLQHIQH HEEASLAQGE QNAIPEGEND NMEAEKSDCA
     DPVQVLQFSD EGAPAAENGD GAGFLPLDDH DEAGDGEVEQ AEHIERRKMQ TEERGYVLRE
     RLEQKPASAI KNETSDPWCG LDPFESCEEK PFKKGKHYTL PRGIAEDLSS NKRKRKLPCK
     LQDFMKWFSS THWDGSEAMK SRRKGPTFAD MEVLYWKHIK ERMTAQRQLH RRMGAQFVKE
     VTLLNQEEEL VNPLEEPRDA DYLDYDGPAD DASDHEDLGE NIPACLREEP ALGDIEPVTL
     HDQLSYEELV RRNVELFMAN SQKYAQETVL SLRVREWEDK MGPQLQEQEE RGAFDIHDYG
     DRLTAQFSKV GEWRSFASLM ADKEPYEVCR YMLASLQLAN DYTVEVSQKP GLHEGLDTMA
     LRLLSQQKAH ERFKTYTAPS ISQQ