ID   CNFN_MOUSE              Reviewed;         111 AA.
AC   Q6PCW6;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Cornifelin;
GN   Name=Cnfn;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Jaw, and Limb;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   FUNCTION, AND INTERACTION WITH LORICIN AND INVOLUCRIN.
RX   PubMed=15147942; DOI=10.1016/j.bbrc.2004.04.109;
RA   Michibata H., Chiba H., Wakimoto K., Seishima M., Kawasaki S., Okubo K.,
RA   Mitsui H., Torii H., Imai Y.;
RT   "Identification and characterization of a novel component of the cornified
RT   envelope, cornifelin.";
RL   Biochem. Biophys. Res. Commun. 318:803-813(2004).
CC   -!- FUNCTION: Part of the insoluble cornified cell envelope (CE) of
CC       stratified squamous epithelia. {ECO:0000269|PubMed:15147942}.
CC   -!- SUBUNIT: Directly or indirectly cross-linked to CE proteins loricin and
CC       involucrin (IVL).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Constituent of the scaffolding of
CC       the cornified envelope. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cornifelin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC059093; AAH59093.1; -; mRNA.
DR   CCDS; CCDS39838.1; -.
DR   RefSeq; NP_001074844.1; NM_001081375.1.
DR   AlphaFoldDB; Q6PCW6; -.
DR   STRING; 10090.ENSMUSP00000130957; -.
DR   SwissPalm; Q6PCW6; -.
DR   PaxDb; Q6PCW6; -.
DR   PRIDE; Q6PCW6; -.
DR   ProteomicsDB; 285506; -.
DR   Antibodypedia; 62296; 21 antibodies from 8 providers.
DR   DNASU; 72383; -.
DR   Ensembl; ENSMUST00000076276; ENSMUSP00000075625; ENSMUSG00000063651.
DR   GeneID; 72383; -.
DR   KEGG; mmu:72383; -.
DR   UCSC; uc009fsl.1; mouse.
DR   CTD; 84518; -.
DR   MGI; MGI:1919633; Cnfn.
DR   VEuPathDB; HostDB:ENSMUSG00000063651; -.
DR   eggNOG; ENOG502S8N3; Eukaryota.
DR   GeneTree; ENSGT00940000161202; -.
DR   HOGENOM; CLU_083147_5_2_1; -.
DR   InParanoid; Q6PCW6; -.
DR   OMA; CASTCYQ; -.
DR   PhylomeDB; Q6PCW6; -.
DR   BioGRID-ORCS; 72383; 3 hits in 76 CRISPR screens.
DR   ChiTaRS; Cnfn; mouse.
DR   PRO; PR:Q6PCW6; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q6PCW6; protein.
DR   Bgee; ENSMUSG00000063651; Expressed in esophagus and 52 other tissues.
DR   ExpressionAtlas; Q6PCW6; baseline and differential.
DR   Genevisible; Q6PCW6; MM.
DR   GO; GO:0001533; C:cornified envelope; ISO:MGI.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR   InterPro; IPR006461; PLAC_motif_containing.
DR   PANTHER; PTHR15907; PTHR15907; 1.
DR   Pfam; PF04749; PLAC8; 1.
DR   TIGRFAMs; TIGR01571; A_thal_Cys_rich; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Keratinization; Reference proteome.
FT   CHAIN           1..111
FT                   /note="Cornifelin"
FT                   /id="PRO_0000261196"
SQ   SEQUENCE   111 AA;  12302 MW;  781132930E7343FA CRC64;
     MSYPVTSQPQ CANTCYQTQL SDWHTGLTDC CNDMPVCLCG TFAPLCLACR ISDDFGECCC
     APYLPGGLHS LRTGMRERYH IQGSVGHDWA ALTFCLPCAL CQMARELKIR E