CNG11_ARATH
ID CNG11_ARATH Reviewed; 621 AA.
AC Q9SKD6; Q682T0;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Cyclic nucleotide-gated ion channel 11;
DE AltName: Full=Cyclic nucleotide- and calmodulin-regulated ion channel 11;
GN Name=CNGC11; OrderedLocusNames=At2g46440; ORFNames=F11C10.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: Putative cyclic nucleotide-gated ion channel.
CC -!- SUBUNIT: Homotetramer or heterotetramer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The binding of calmodulin to the C-terminus might interfere
CC with cyclic nucleotide binding and thus channel activation.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC
CC 1.A.1.5) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD23057.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006526; AAD23057.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC10696.1; -; Genomic_DNA.
DR EMBL; AK175287; BAD43050.1; -; mRNA.
DR PIR; H84902; H84902.
DR RefSeq; NP_182167.2; NM_130208.4.
DR AlphaFoldDB; Q9SKD6; -.
DR SMR; Q9SKD6; -.
DR BioGRID; 4587; 1.
DR STRING; 3702.AT2G46440.1; -.
DR iPTMnet; Q9SKD6; -.
DR PaxDb; Q9SKD6; -.
DR PRIDE; Q9SKD6; -.
DR ProteomicsDB; 220393; -.
DR EnsemblPlants; AT2G46440.1; AT2G46440.1; AT2G46440.
DR GeneID; 819252; -.
DR Gramene; AT2G46440.1; AT2G46440.1; AT2G46440.
DR KEGG; ath:AT2G46440; -.
DR Araport; AT2G46440; -.
DR TAIR; locus:2039099; AT2G46440.
DR eggNOG; KOG0498; Eukaryota.
DR HOGENOM; CLU_013069_3_0_1; -.
DR InParanoid; Q9SKD6; -.
DR OMA; CWHEACA; -.
DR OrthoDB; 1073751at2759; -.
DR PhylomeDB; Q9SKD6; -.
DR PRO; PR:Q9SKD6; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SKD6; baseline and differential.
DR Genevisible; Q9SKD6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IGI:TAIR.
DR GO; GO:0009617; P:response to bacterium; IGI:TAIR.
DR GO; GO:0009620; P:response to fungus; IMP:TAIR.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; cAMP; cAMP-binding; Cell membrane; cGMP; cGMP-binding;
KW Ion channel; Ion transport; Ligand-gated ion channel; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..621
FT /note="Cyclic nucleotide-gated ion channel 11"
FT /id="PRO_0000219339"
FT TOPO_DOM 1..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=H1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..76
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=H2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=H3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..162
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical; Name=H4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=H5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..329
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical; Name=H6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 351..621
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 569..598
FT /note="IQ"
FT REGION 549..564
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000250"
FT BINDING 435..556
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT BINDING 506
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT /evidence="ECO:0000250"
SQ SEQUENCE 621 AA; 71475 MW; 0538C566AFC1F6A5 CRC64;
MNLQRRKFVR LDSTGVDGKL KSVRGRLKKV YGKMKTLENW RKTVLLACVV ALAIDPLFLF
IPLIDSQRFC FTFDKTLVAV VCVIRTFIDT FYVIHIIYYL ITETIAPRSQ ASLRGEIVVH
SKATLKTRLL FHFIVDIISV LPIPQVVVLT LIPLSASLVS ERILKWIILS QYVPRIIRMY
PLYKEVTRAF GTVAESKRVG AALNFFLYML HSYVCGAFWY LSSIERKSTC WRAACARTSD
CNLTVTDLLC KRAGSDNIRF LNTSCPLIDP AQITNSTDFD FGMYIDALKS GVLEVKPKDF
PRKFVYCFWW GLRNISALGQ NLETSNSAGE IFFAIIICVS GLLLFAVLIG NVQKYLQSST
TRVDEMEEKK RDTEKWMSYR EIPEYLKERI RRFEDYKWRR TKGTEEEALL RSLPKDLRLE
TKRYLFLKLL KKVPLLQAMD DQLLDALCAR LKTVHYTEKS YIVREGEPVE DMLFIMRGNL
ISTTTYGGRT GFFNSVDLIA GDSCGDLLTW ALYSLSSQFP ISSRTVQALT EVEGFVISAD
DLKFVATQYR RLHSKQLQHM FRFYSLQWQT WAACFIQAAW KRHCRRKLSK ALREEEGKLH
NTLQNDDSGG NKLNLGAAIY A
