CNG13_ARATH
ID CNG13_ARATH Reviewed; 696 AA.
AC Q9LD40;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Putative cyclic nucleotide-gated ion channel 13;
DE AltName: Full=Cyclic nucleotide- and calmodulin-regulated ion channel 13;
GN Name=CNGC13; OrderedLocusNames=At4g01010; ORFNames=F3I3.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: Putative cyclic nucleotide-gated ion channel.
CC -!- SUBUNIT: Homotetramer or heterotetramer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The binding of calmodulin to the C-terminus might interfere
CC with cyclic nucleotide binding and thus channel activation.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC
CC 1.A.1.5) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB45784.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80910.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL080237; CAB45784.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161491; CAB80910.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE81966.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM68044.1; -; Genomic_DNA.
DR PIR; D85013; D85013.
DR RefSeq; NP_001319839.1; NM_001340295.1.
DR RefSeq; NP_192010.2; NM_116329.3.
DR AlphaFoldDB; Q9LD40; -.
DR BioGRID; 11726; 38.
DR IntAct; Q9LD40; 3.
DR STRING; 3702.AT4G01010.1; -.
DR PaxDb; Q9LD40; -.
DR PRIDE; Q9LD40; -.
DR ProteomicsDB; 220538; -.
DR EnsemblPlants; AT4G01010.1; AT4G01010.1; AT4G01010.
DR EnsemblPlants; AT4G01010.2; AT4G01010.2; AT4G01010.
DR GeneID; 826427; -.
DR Gramene; AT4G01010.1; AT4G01010.1; AT4G01010.
DR Gramene; AT4G01010.2; AT4G01010.2; AT4G01010.
DR KEGG; ath:AT4G01010; -.
DR Araport; AT4G01010; -.
DR TAIR; locus:2125206; AT4G01010.
DR eggNOG; KOG0498; Eukaryota.
DR HOGENOM; CLU_013069_3_0_1; -.
DR InParanoid; Q9LD40; -.
DR OMA; FQHTFKF; -.
DR OrthoDB; 1073751at2759; -.
DR PhylomeDB; Q9LD40; -.
DR PRO; PR:Q9LD40; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9LD40; baseline and differential.
DR Genevisible; Q9LD40; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding; cAMP; cAMP-binding; Cell membrane; cGMP; cGMP-binding;
KW Ion channel; Ion transport; Ligand-gated ion channel; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..696
FT /note="Putative cyclic nucleotide-gated ion channel 13"
FT /id="PRO_0000219341"
FT TOPO_DOM 1..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=H1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=H2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical; Name=H3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=H4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=H5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..367
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical; Name=H6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..696
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 610..639
FT /note="IQ"
FT REGION 45..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..605
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000250"
FT REGION 677..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 474..598
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT BINDING 545
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT /evidence="ECO:0000250"
SQ SEQUENCE 696 AA; 80474 MW; E742396115F767B4 CRC64;
MAFGRNNRVR FRDWISEGTE YGYGRNKARP SLNTVLKNVR RGLKKPLSFG SHNKKRDSNS
STTTQKNIIN PQGSFLQNWN KIFLFASVIA LAIDPLFFYI PIVDGERHCL NLHRNLEIAA
SVLRTFIDAF YIIHIVFQFR TAYISPSSRV FGRGELVDDP KAIAIKYLSS YFIIDLLSIL
PLPQLVVLAV IPNVNKPVSL ITKDYLITVI FTQYIPRILR IYPLYTEVTR TSGIVTETAW
AGAAWNLSLY MLASHVFGAL WYLISVERED RCWREACEKI PEVCNFRFLY CDGNSSVRND
FLTTSCPFIN PDDITNSTVF NFGIFTDALK SGIVESDDFW KKFFYCFWWG LRNLSALGQN
LNTSKFVGEI IFAVSICISG LVLFALLIGN MQKYLESTTV REEEMRVRKR DAEQWMSHRM
LPDDLRKRIR RYEQYKWQET RGVEEENLLR NLPKDLRRDI KRHFCLDLLK KVPLFEIMDE
QLLDAVCDKL KPVLYTENSY AIREGDPVEE MLFVMRGKLM SATTNGGRTG FFNAVYLKPS
DFCGEDLLTW ALDPQSSSHF PISTRTVQAL TEVEAFALAA DDLKLVASQF RRLHSKQLQH
TFRFYSVQWR TWGASFIQAA WRRHCRRKLA RSLTEEEDRF RNAITKRERN AASSSSLVAT
LYASRFASNA LRNLRTNNLP LLPPKPSEPD FSLRNP
