CNG14_ARATH
ID CNG14_ARATH Reviewed; 726 AA.
AC Q9SJA4; Q0WS20;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Probable cyclic nucleotide-gated ion channel 14;
DE AltName: Full=Cyclic nucleotide- and calmodulin-regulated ion channel 14;
GN Name=CNGC14; OrderedLocusNames=At2g24610; ORFNames=F25P17.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: Probable cyclic nucleotide-gated ion channel.
CC -!- SUBUNIT: Homotetramer or heterotetramer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The binding of calmodulin to the C-terminus might interfere
CC with cyclic nucleotide binding and thus channel activation.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC
CC 1.A.1.5) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD23886.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006954; AAD23886.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07601.1; -; Genomic_DNA.
DR EMBL; AK228122; BAF00079.1; -; mRNA.
DR PIR; G84638; G84638.
DR RefSeq; NP_850056.1; NM_179725.2.
DR AlphaFoldDB; Q9SJA4; -.
DR BioGRID; 2349; 2.
DR STRING; 3702.AT2G24610.1; -.
DR PaxDb; Q9SJA4; -.
DR PRIDE; Q9SJA4; -.
DR ProteomicsDB; 220295; -.
DR EnsemblPlants; AT2G24610.1; AT2G24610.1; AT2G24610.
DR GeneID; 816997; -.
DR Gramene; AT2G24610.1; AT2G24610.1; AT2G24610.
DR KEGG; ath:AT2G24610; -.
DR Araport; AT2G24610; -.
DR TAIR; locus:2046703; AT2G24610.
DR eggNOG; KOG0498; Eukaryota.
DR HOGENOM; CLU_013069_3_0_1; -.
DR InParanoid; Q9SJA4; -.
DR OMA; WKSECRN; -.
DR PhylomeDB; Q9SJA4; -.
DR PRO; PR:Q9SJA4; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SJA4; baseline and differential.
DR Genevisible; Q9SJA4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; cAMP; cAMP-binding; Cell membrane; cGMP; cGMP-binding;
KW Ion channel; Ion transport; Ligand-gated ion channel; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..726
FT /note="Probable cyclic nucleotide-gated ion channel 14"
FT /id="PRO_0000219342"
FT TOPO_DOM 1..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=H1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..122
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical; Name=H2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..177
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical; Name=H3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=H4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..252
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=H5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..377
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical; Name=H6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..726
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 617..646
FT /note="IQ"
FT REGION 597..612
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000250"
FT REGION 707..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 481..605
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT BINDING 552
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT /evidence="ECO:0000250"
SQ SEQUENCE 726 AA; 83454 MW; AA728001900EAD83 CRC64;
MEFKRDNTVR FYGDEKQTIE VGEKRVPLFK STTAPFMKQE VLPKKSKTRL KIPRFGRFKV
FPENFEIERD KILDPGGDAV LQWNRVFLFW CLVALYVDPL FFFLSSVKRI GRSSCMTTDL
KLGIVITFFR TLADLFYVLH IVIKFRTAYV SRTSRVFGRG ELVKDPKLIA RRYLRSDFIV
DLIACLPLPQ IVSWFILPSI RSSHSDHTTN ALVLIVLVQY IPRLYLIFPL SAEIIKATGV
VTTTAWAGAA YNLLQYMLAS HILGSAWYLL SIERQATCWK AECHKESVPL QCVTDFFDCG
TLHRDDRNNW QNTTVVFSNC DPSNNIQFTF GIFADALTKN VVSSPFLEKY LYCLWFGLQN
LSSYGQNLST STSVLETMFA ILVAIFGLVL FALLIGNMQT YLQSITVRLE EWRLKRRDTE
EWMGHRLLPQ NLRERVRRFV QYKWLATRGV DEETILHSLP ADLRRDIQRH LCLDLVRRVP
LFAQMDDQLL DAICERLASS LSTQGNYIVR EGDPVTEMLF IIRGKLESST TNGGRTGFFN
SITLRPGDFC GEELLAWALL PKSTVNLPSS TRTVRALEEV EAFALQAGDL KFVANQFRRL
HSKKLQHTFR YYSHQWRTWA ACFVQVAWRR YKRKKLAKSL SLAESFSSYD EEEAVAVAAT
EEMSHEGEAQ SGAKARHHTS NVKPHFAATI LASRFAKNTR RTAHKLKDVE IPMLPKPDEP
DFSVDD
