CNG19_ARATH
ID CNG19_ARATH Reviewed; 729 AA.
AC Q9LDR2;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Putative cyclic nucleotide-gated ion channel 19;
DE AltName: Full=Cyclic nucleotide-binding transporter 2;
GN Name=CNGC19; Synonyms=CNBT2; OrderedLocusNames=At3g17690; ORFNames=MKP6.27;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Wolff P., Palme K.;
RT "Two genes encoding putative cyclic nucleotide-binding ion transporters
RT from Arabidopsis thaliana.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: Putative cyclic nucleotide-gated ion channel.
CC -!- SUBUNIT: Homotetramer or heterotetramer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC
CC 1.A.1.5) family. {ECO:0000305}.
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DR EMBL; AF148542; AAF73129.1; -; Genomic_DNA.
DR EMBL; AB022219; BAB02061.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75993.1; -; Genomic_DNA.
DR RefSeq; NP_188396.2; NM_112650.4.
DR AlphaFoldDB; Q9LDR2; -.
DR BioGRID; 6369; 10.
DR IntAct; Q9LDR2; 8.
DR STRING; 3702.AT3G17690.1; -.
DR TCDB; 1.A.1.5.23; the voltage-gated ion channel (vic) superfamily.
DR PaxDb; Q9LDR2; -.
DR PRIDE; Q9LDR2; -.
DR EnsemblPlants; AT3G17690.1; AT3G17690.1; AT3G17690.
DR GeneID; 821036; -.
DR Gramene; AT3G17690.1; AT3G17690.1; AT3G17690.
DR KEGG; ath:AT3G17690; -.
DR Araport; AT3G17690; -.
DR TAIR; locus:2090562; AT3G17690.
DR eggNOG; KOG0498; Eukaryota.
DR HOGENOM; CLU_013069_2_0_1; -.
DR InParanoid; Q9LDR2; -.
DR OMA; CGRGINI; -.
DR OrthoDB; 212763at2759; -.
DR PhylomeDB; Q9LDR2; -.
DR PRO; PR:Q9LDR2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LDR2; baseline and differential.
DR Genevisible; Q9LDR2; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.
DR GO; GO:0099604; F:ligand-gated calcium channel activity; IDA:TAIR.
DR GO; GO:0080027; P:response to herbivore; IMP:TAIR.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding; cAMP; cAMP-binding; Cell membrane; cGMP; cGMP-binding;
KW Ion channel; Ion transport; Ligand-gated ion channel; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..729
FT /note="Putative cyclic nucleotide-gated ion channel 19"
FT /id="PRO_0000219347"
FT TOPO_DOM 1..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical; Name=H1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=H2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=H3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..295
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical; Name=H4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..332
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical; Name=H5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 354..451
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 452..472
FT /note="Helical; Name=H6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 473..729
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 699..728
FT /note="IQ"
FT REGION 52..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..694
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000250"
FT COMPBIAS 54..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 560..677
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT BINDING 625
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT /evidence="ECO:0000250"
SQ SEQUENCE 729 AA; 84049 MW; 65A288893CC298E3 CRC64;
MAHTRTFTSR NRSVSLSNPS FSIDGFDNST VTLGYTGPLR TQRIRPPLVQ MSGPIHSTRR
TEPLFSPSPQ ESPDSSSTVD VPPEDDFVFK NANLLRSGQL GMCNDPYCTT CPSYYNRQAA
QLHTSRVSAS RFRTVLYGDA RGWAKRFASS VRRCLPGIMN PHSKFVQVWT RVLAFSSLVA
IFIDPLFFFL LLIQQDNKCI AIDWRATKVL VSLRSITDLI FFINILLQFR LAYVAPESRI
VGAGQLVDHP RKIARHYFRG KFLLDMFIVF PIPQIMILRI IPLHLGTRRE ESEKQILRAT
VLFQYIPKLY RLLPLLAGQT STGFIFESAW ANFVINLLTF MLAGHAVGSC WYLSALQRVK
KCMLNAWNIS ADERRNLIDC ARGSYASKSQ RDLWRDNASV NACFQENGYT YGIYLKAVNL
TNESSFFTRF SYSLYWGFQQ ISTLAGNLSP SYSVGEVFFT MGIIGLGLLL FARLIGNMHN
FLQSLDRRRM EMMLRKRDVE QWMSHRRLPE DIRKRVREVE RYTWAATRGV NEELLFENMP
DDLQRDIRRH LFKFLKKVRI FSLMDESVLD SIRERLKQRT YIRSSTVLHH RGLVEKMVFI
VRGEMESIGE DGSVLPLSEG DVCGEELLTW CLSSINPDGT RIKMPPKGLV SNRNVRCVTN
VEAFSLSVAD LEDVTSLFSR FLRSHRVQGA IRYESPYWRL RAAMQIQVAW RYRKRQLQRL
NTAHSNSNR
